MAPRE1 promotes cell cycle progression of hepatocellular carcinoma cells by interacting with CDK2

Liang, Xing-Hua; Feng, Zhengping; Liu, Fo-Qiu; Yan, Rong; Yin, Liangyu; Shen, Hao; Lu, Hailin

doi:10.1002/cbin.11442

Cited by 12 publications

(7 citation statements)

References 30 publications

(43 reference statements)

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“…Based on the latest research, silencing circPVT1 enhances the radiosensitivity in NSCLC via regulating microRNA(miRNA)-1208 [ 13 ]. Another study revealed that circRNA_100565 facilitates cisplatin-resistant NSCLC via adjusting miR-337-3p/a disintegrin and metalloproteinases 28 (ADAM28) axis in proliferation, apoptosis and autophagy [ 14 ]. CircSOX13 is a type of circRNA.…”

Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: Circular RNA SOX13 promotes malignant behavior and cisplatin resistance in non-small cell lung cancer through targeting microRNA-3194-3p/microtubule-associated protein RP/EB family member 1

Zhang

Peng

et al. 2022

Bioengineered

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Circular RNA (circRNA) presents an essential regulatory role in affecting the occurrence and acquired resistance in non-small cell lung cancer (NSCLC), but how circSOX13 impacts NSCLC is unclear. In this work it was found that compared with adjacent normal tissues, circSOX13 and the microtubule-associated protein RP/EB family member 1 (MAPRE1) were signally up-regulated in NSCLC while miR-3194-3p was signally lowered. Pulmonary function tests (PETs) revealed that knocking down circSOX13 or overexpressing miR-3194-3p inhibited NSCLC proliferation, invasion and migration but promoted its apoptosis. The promoting effect of overexpressing circSOX13 on NSCLC was reversed via knocking down MAPRE1. Additionally, knocking down circSOX13 reduced cisplatin resistance in NSCLC. Furthermore, circSOX13 mediated MAPRE1 expression via competitively binding miR-3194-3p to exert its tumorigenic impact. To conclude, this work clarified the carcinogenic impact of circSOX13-miR-3194-3p-MAPRE1 axis on NSCLC and DDP resistance. CircSOX13 can be a potential diagnostic marker and therapeutic target for NSCLC, thus providing a new insight for clinically reversing its acquired resistance.

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Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: Circular RNA SOX13 promotes malignant behavior and cisplatin resistance in non-small cell lung cancer through targeting microRNA-3194-3p/microtubule-associated protein RP/EB family member 1

Zhang

Peng

et al. 2022

Bioengineered

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“…But molecular mechanism of HCC is still less studied. An important role in HCC is cell cycle regulator [ 19 – 21 ]. Our study also demonstrates that the functional enrichment of DEGs is significantly upregulated in the cell cycle pathway.…”

Section: Discussionmentioning

confidence: 99%

Screening Hub Genes of Hepatocellular Carcinoma Based on Public Databases

Gao

Zhu

et al. 2021

Computational and Mathematical Methods in Medicine

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Tumor recurrence and metastasis often occur in HCC patients after surgery, and the prognosis is not optimistic. Hence, searching effective biomarkers for prognosis of is of great importance. Firstly, HCC-related data was acquired from the TCGA and GEO databases. Based on GEO data, 256 differentially expressed genes (DEGs) were obtained firstly. Subsequently, to clarify function of DEGs, clusterProfiler package was used to conduct functional enrichment analyses on DEGs. Protein-protein interaction (PPI) network analysis screened 20 key genes. The key genes were filtered via GEPIA database, by which 11 hub genes (F9, CYP3A4, ASPM, AURKA, CDC20, CDCA5, NCAP, PRC1, PTTG1, TOP2A, and KIFC1) were screened out. Then, univariate Cox analysis was applied to construct a prognostic model, followed by a prediction performance validation. With the risk score calculated by the model and common clinical features, univariate and multivariate analyses were carried out to assess whether the prognostic model could be used independently for prognostic prediction. In conclusion, the current study screened HCC prognostic gene signature based on public databases.

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“…However, there was no investigation about PPAR signaling pathway in HCC, which is reserved for further research. Cell cycle pathway was a critical mechanism, by which many genes could promote HCC cell proliferation [50][51][52]. The reasonable explanation was that lnc-CCNY-1 promote tumor progression of HCC by downregulating PPAR signaling pathway and upregulating cell cycle.…”

Section: Discussionmentioning

confidence: 99%

Identification of Epithelial Mesenchymal Transition-Related lncRNAs Associated with Prognosis and Tumor Immune Microenvironment of Hepatocellular Carcinoma

et al. 2022

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Purpose. The long noncoding RNAs (lncRNAs) play the important role in tumor occurrence and progression, and the epithelial to mesenchymal transition (EMT) is the critical process for tumor migration. However, the role of EMT-related lncRNA in hepatocellular carcinoma (HCC) has not been elucidated. Methods. In this study, we selected the EMT-related lncRNAs in HCC by using data from The Cancer Genome Atlas database (TCGA). Two prognostic models of the overall survival (OS) and relapse-free survival (RFS) were constructed and validated through Cox regression model, Kaplan-Meier analysis, and the receiver-operating characteristic (ROC) curves. The unsupervised clustering analysis was utilized to investigate the association between EMT-lncRNAs with tumor immune microenvironment. ESTIMATE algorithm and gene set enrichment analysis (GSEA) were used to estimate tumor microenvironment and associated KEGG pathways. Results. Two EMT-related lncRNA prognostic models of OS and RFS were constructed. Kaplan-Meier curves showed the dismal prognosis of OS and RFS in the group with high-risk score. The ROC curves and AUC values in two prognostic models indicated the discriminative value in the training set and validation set. Patients with HCC were clustered into two subgroups according the unsupervised clustering analysis. Lnc-CCNY-1 was selected as the key lncRNA. GSVA analysis showed that lnc-CCNY-1 was negatively associated with peroxisome proliferator-activated receptor (PPAR) signaling pathway and positively correlated with CELL cycle pathway. Conclusion. Two EMT-related lncRNA prognostic models of OS and RFS were constructed to discriminate patients and predict prognosis of HCC. EMT-related lncRNAs may play a role on prognosis of HCC by influencing the immune microenvironment. Lnc-CCNY-1 was selected as the key EMT-related lncRNA for further exploration.

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MAPRE1 promotes cell cycle progression of hepatocellular carcinoma cells by interacting with CDK2

Cited by 12 publications

References 30 publications

RETRACTED ARTICLE: Circular RNA SOX13 promotes malignant behavior and cisplatin resistance in non-small cell lung cancer through targeting microRNA-3194-3p/microtubule-associated protein RP/EB family member 1

RETRACTED ARTICLE: Circular RNA SOX13 promotes malignant behavior and cisplatin resistance in non-small cell lung cancer through targeting microRNA-3194-3p/microtubule-associated protein RP/EB family member 1

Screening Hub Genes of Hepatocellular Carcinoma Based on Public Databases

Identification of Epithelial Mesenchymal Transition-Related lncRNAs Associated with Prognosis and Tumor Immune Microenvironment of Hepatocellular Carcinoma

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