RETRACTED ARTICLE: Circular RNA SOX13 promotes malignant behavior and cisplatin resistance in non-small cell lung cancer through targeting microRNA-3194-3p/microtubule-associated protein RP/EB family member 1

Abstract

Circular RNA (circRNA) presents an essential regulatory role in affecting the occurrence and acquired resistance in non-small cell lung cancer (NSCLC), but how circSOX13 impacts NSCLC is unclear. In this work it was found that compared with adjacent normal tissues, circSOX13 and the microtubule-associated protein RP/EB family member 1 (MAPRE1) were signally up-regulated in NSCLC while miR-3194-3p was signally lowered. Pulmonary function tests (PETs) revealed that knocking down circSOX13 or overexpressing miR-3194-3p inhibited NSCLC proliferation, invasion and migration but promoted its apoptosis. The promoting effect of overexpressing circSOX13 on NSCLC was reversed via knocking down MAPRE1. Additionally, knocking down circSOX13 reduced cisplatin resistance in NSCLC. Furthermore, circSOX13 mediated MAPRE1 expression via competitively binding miR-3194-3p to exert its tumorigenic impact. To conclude, this work clarified the carcinogenic impact of circSOX13-miR-3194-3p-MAPRE1 axis on NSCLC and DDP resistance. CircSOX13 can be a potential diagnostic marker and therapeutic target for NSCLC, thus providing a new insight for clinically reversing its acquired resistance.

CircTPST2 inhibits cisplatin sensitivity in head and neck squamous cell carcinoma by sponging miR-770-5p and interacting with Nucleolin

“…CircRNA is a closed-loop structure molecule with covalent bonds that is more stable than linear RNA [20,21]. It was found that circRNAs play important roles in tumor malignancy, including tumor proliferation, metastasis, chemosensitivity, and radiosensitivity [22].…”

The emerging role of circular RNAs in drug resistance of non-small cell lung cancer

“…In this review, we summarized recent findings and research breakthroughs on the role of specific circRNAs in drug resistance in NSCLC. The study of how circRNAs mediate drug resistance is one of research hot topics ( 39 ). It has been documented that circRNAs control cellular processes through several mechanisms which include modulating transcription ( 23 ), serving as sponge for miRNAs ( 134 ), acting as a platform or sponge for proteins ( 65 ), regulating splicing at the same locus ( 22 ), forming functional circRNA-protein complexes ( 65 ), directly binding to mRNAs to regulate their expression, outcompeting linear mRNAs for protein binding and encoding peptides ( 5 , 146 ).…”

“…Circ_100565 was overexpressed in CDDP-resistant NSCLC and knockdown of circ_100565 could overrode the resistance (16). In addition, Zhang et al identified that circSOX13 enhanced MAPRE1 expression by competitively binding miR-3194-3p, resulting in CDDP resistance in NSCLC cells (39). Similarly, circ_103762 expression was elevated following CDDP treatment in NSCLC patients.…”

“…suggested that circSOX13 was significantly overexpressed in NSCLC. The elevated circSOX13 was able to increase the malignant behavior and CDDP resistance of NSCLC via binding to miR-3194-3p ( 39 ). In addition, circ_PRMT5 was demonstrated to promote CDDP resistance by sponging miR‐4458, resulting in the overexpression of miR‐4458 targeted gene REV3L in NSCLC ( 40 ).…”

Circular RNA circ_0002360 regulates the Taxol resistance and malignant behaviors of Taxol-resistant non-small cell lung cancer cells by microRNA-585-3p-dependent modulation of G protein regulated inducer of neurite outgrowth 1

“…Zhang et al . reported that circRNA SRY-box transcription factor 13 (circSOX13) functioned as a strong contributor to NSCLC cell cisplatin resistance and malignant behaviors via microtubule-associated protein RP/EB family member 1 (MAPRE1) upregulation by sponging miR-3194-3p [ 12 ]. Human circ_0002360, generated by the back-spliced exons of RUNX family transcription factor 1 (RUNX1), is highly expressed in NSCLC and operates as a promoter in NSCLC [ 13 , 14 ].…”