“…Similarly, t tolepine (1), nearly all naturally occurring pyridoacridines have been shown to act a intercalating agents, resulting in cytotoxic effects in cultured tumor cells [54,55,58 also possess the ability to inhibit topoisomerase II [53,58] and further contain bio profiles such as antibacterial, antifungal, antiviral, antiparasitic and inse [53,56,57,[59][60][61]. Consequently, it is postulated that the pyridoacridines and the thetic derivatives are pivotal for the future generation of medicinal compounds [5 Recently, we described the preparation of several isocryptolepine regioisome certain chemoisomers [52]. In this paper, we present modifications to our previo thetic strategies which allowed for the realization of novel tetracyclic ring-system pounds 4b, 8, and 9) along with the N-alkylation of several compounds to furni analogues (compounds 3b, 3c, 10, and 21).…”