Mapping the human pulmonary surfactant-associated protein B gene (SFTP3) to chromosome 2p12→p11.2

Vamvakopoulos, Nicholas C.; Modi, William S.; Floros, Joanna

doi:10.1159/000133878

Cited by 36 publications

(23 citation statements)

References 3 publications

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“…Genes belonging to cluster (a) including SFTPB, FOLR1, and MMP-7 were more abundantly expressed in adenocarcinomas than in SCCs, while genes in cluster (b) were more abundantly expressed in SCCs than in adenocarcinomas. SFTPB is essential for the maintenance of respiratory function in type II alveolar cells (Vamvakopoulos et al, 1995). FOLR1 and MMP-7 (matrilysin) were highly expressed in adenocarcinomas, and the overexpression of MMP-7 was indicated to have tendencies toward lymph-node or distant metastases (Franklin et al, 1994;Kawano et al, 1997).…”

Section: Cluster Analysis Of Gene Expressionmentioning

confidence: 99%

Expression profiles of non-small cell lung cancers on cDNA microarrays: Identification of genes for prediction of lymph-node metastasis and sensitivity to anti-cancer drugs

et al. 2003

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To investigate genes involved in pulmonary carcinogenesis and those related to sensitivity of nonsmall cell lung cancers (NSCLCs) to therapeutic drugs, we performed cDNA microarray analysis of 37 NSCLCs after lasercapture microdissection of cancer cells from primary tumors. A clustering algorithm applied to the expression data easily distinguished two major histological types of non-small cell lung cancer, adenocarcinoma and squamous cell carcinoma. Subsequent analysis of the 18 adenocarcinomas identified 40 genes whose expression levels could separate cases with lymph-node metastasis from those without metastasis. In addition, we compared the expression data with measurements of the sensitivity of surgically dissected NSCLC specimens to six anti-cancer drugs (docetaxel, paclitaxel, irinotecan, cisplatin, gemcitabine, and vinorelbine), as measured by the CD-DST (collagen gel droplet embedded culture-drug sensitivity test) method. We found significant associations between expression levels of dozens of genes and chemosensitivity of NSCLCs. Our results provide valuable information for eventually identifying predictive markers and novel therapeutic target molecules for this type of cancer.

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Section: Cluster Analysis Of Gene Expressionmentioning

confidence: 99%

Expression profiles of non-small cell lung cancers on cDNA microarrays: Identification of genes for prediction of lymph-node metastasis and sensitivity to anti-cancer drugs

et al. 2003

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“…The human SP-B is a single gene locus on chromosome 2 [22]. A number of mutations and polymorphisms have been identified and characterized for SP-B [1,[23][24][25].…”

Section: Surfactant Protein Bmentioning

confidence: 99%

Surfactant Protein A and B Genetic Variants and Respiratory Distress Syndrome: Allele Interactions

Floros

Fan

2001

Neonatology

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The contribution of multiple genetic components in disease pathogenesis is relevant to both diseases of multifactorial and/or multigenic etiology such as the respiratory distress syndrome (RDS) and to diseases where a single gene has been identified as the disease-causing gene. An example of the latter is cystic fibrosis (CF) where the disease-causing gene has been clearly identified as the CF transmembrane conductance regulator gene, but genetic variants of the mannose binding protein and surfactant protein A have been associated with disease severity in CF. The overall rationale for considering genetic contribution to disease pathogenesis is based on the premise that all diseases or deaths (except perhaps those resulting from trauma) have a genetic component. The difference in genetic contribution among various diseases is the percent contribution and the number of factors that make this contribution. Therefore, if the number of genetic contributors is small and the percentage of genetic contribution is high it may be less challenging to identify such factors. In this paper we summarize allele associations and discuss allele interaction of the surfactant protein genes in relation to RDS (the term allele and genetic variant will be used interchangeably).

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“…The gene for SP-B has been localized on the short arm of chromosome 2 (Emrie et al, 1988;Vamvakopoulos et al, 1995), consisting of 11 exons with the first 10 encoding the precursor protein. Different polymorphisms within the SP-B gene have been described (Pilot-Matias et al, 1989;Nogee et al, 1994;Floros et al, 1995;Lin et al, 1998Lin et al, , 1999a and SP-B gene variations have been associated with several diseases, such as respiratory distress syndrome (RDS) , COPD (Seifart et al, 2002) and congenital alveolar proteinosis (Nogee et al, 1994;Lin et al, 1998).…”

mentioning

confidence: 99%

Surfactant protein B gene variations enhance susceptibility to squamous cell carcinoma of the lung in German patients

Seifart

Plagens

et al. 2002

Br J Cancer

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Genetic factors are thought to influence the risk for lung cancer. Since pulmonary surfactant mediates the response to inhaled carcinogenic substances, candidate genes may be among those coding for pulmonary surfactant proteins. In the present matched case -control study a polymorphism within intron 4 of the gene coding for surfactant specific protein B was analysed in 357 individuals. They were divided into 117 patients with lung cancer (40 patients with small cell lung cancer, 77 patients with non small cell lung cancer), matched controls and 123 healthy individuals. Surfactant protein B gene variants were analysed using specific PCR and cloned surfactant protein B sequences as controls. The frequency of the intron 4 variation was similar in both control groups (13.0% and 9.4%), whereas it was increased in the small cell lung cancer group (17.5%) and the non small cell lung cancer group (16.9%). The gene variation was found significantly more frequently in patients with squamous cell carcinoma (25.0%, P=0.016, odds ratio=3.2, 95%CI=1.24 -8.28) than in the controls. These results indicate an association of the surfactant protein B intron 4 variants and/or its flanking loci with mechanisms that may enhance lung cancer susceptibility, especially to squamous cell carcinoma of the lung.

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Mapping the human pulmonary surfactant-associated protein B gene (SFTP3) to chromosome 2p12→p11.2

Cited by 36 publications

References 3 publications

Expression profiles of non-small cell lung cancers on cDNA microarrays: Identification of genes for prediction of lymph-node metastasis and sensitivity to anti-cancer drugs

Expression profiles of non-small cell lung cancers on cDNA microarrays: Identification of genes for prediction of lymph-node metastasis and sensitivity to anti-cancer drugs

Surfactant Protein A and B Genetic Variants and Respiratory Distress Syndrome: Allele Interactions

Surfactant protein B gene variations enhance susceptibility to squamous cell carcinoma of the lung in German patients

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