Mapping regional oxygenation and flow in pig hearts in vivo using near-infrared spectroscopic imaging

Kupriyanov, V.V.; Nighswander-Rempel, Stephen P.; Xiang, Bo

doi:10.1016/j.yjmcc.2004.07.007

Cited by 36 publications

(43 citation statements)

References 23 publications

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“…Similar to other research groups [2], [3], [25], [26], [27], [28], [29] and [30], our previous studies also successfully employed this model using near infrared spectroscopic imaging [31], [32], [33] and [34]] and contrast-enhanced MRI [5] and [35]. However, occlusion of coronary artery branches results in variable lesion size/volume due to variation in arterial branching patterns in respective pigs.…”

Section: Introductionsupporting

confidence: 68%

Characterization of cryoinjury-induced infarction with manganese-and gadolinium-enhanced MRI and optical spectroscopy in pig hearts

Yang

Sun

Gervai

et al. 2010

Magnetic Resonance Imaging

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Section: Introductionsupporting

confidence: 68%

Characterization of cryoinjury-induced infarction with manganese-and gadolinium-enhanced MRI and optical spectroscopy in pig hearts

Yang

Sun

Gervai

et al. 2010

Magnetic Resonance Imaging

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“…It has to be noted that the OSP method provides a relative OSP value, which remains well above zero even during the no-flow ischemia, as discussed previously [30]. There could be several reasons for this discrepancy.…”

Section: -D Imaging Of Tissue Oxygenation In a Rodent Heart With A Mmentioning

confidence: 75%

Defects in myoglobin oxygenation in KATP-deficient mouse hearts under normal and stress conditions characterized by near infrared spectroscopy and imaging

Jilkina

Glogowski

Kuzio

et al. 2011

International Journal of Cardiology

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Defects in myoglobin oxygenation in K ATP -deficient mouse hearts under normal and stress conditions characterized by near infrared spectroscopy and imaging Abstract BackgroundDisruption of ATP-sensitive potassium (K ATP ) channel activity results in the development of dilated cardiomyopathy in response to different forms of stress, likely due to the underlying metabolic defects. To further understand the role of Kir6.2-containing channels in the development of cardiac disease, we analysed the left ventricular (LV) wall oxygenation and the physiologic responses induced by acute stress in non-dilated Kir6.2 −/− hearts. MethodsControl (C57BL6) and Kir6.2 −/− mouse hearts were perfused in constant flow Langendorff mode with Krebs-Henseleit buffer. Myocardial oxygenation was evaluated using a newly developed technique, near infrared spectroscopic imaging (NIRSI) of the myoglobin (Mb) oxygen saturation parameter (OSP, ratio of oxy-to total Mb). Results2,4-dinitrophenol (DNP, 50-µM) and isoproterenol (0.1-µM) failed to produce a transient vasodilatory response and caused a significant diastolic pressure increase in Kir6.2 −/− hearts. DNP strongly suppressed contractile function in both groups and induced severe mean OSP decreases in Kir6.2 −/− hearts. Isoproterenol-induced decreases in OSP were similar despite the lack of contractile function stimulation in the Kir6.2 −/− group. The index of OSP spatial heterogeneity (relative dispersion, RD) was lower by 15% in the Kir6.2 −/− group at the baseline conditions. Recovery after stress caused reduction of RD values by 20% (DNP) and 8% (isoproterenol) in controls; however, these values did not change in the Kir6.2 −/− group. Conclusions1) NIRSI can be used to analyse 2-D dynamics of LV oxygenation in rodent models of cardiomyopathy; 2) Kir6.2-containing K ATP channels play an important role in maintaining myocardial oxygenation balance under acute stress conditions and in post-stress recovery.

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“…Since the aim of our study was to evaluate the technical feasibility of the intravascular NIR spectroscopy in detecting myocardial ischemia, we deliberately selected low risk patients undergoing OPCAB surgery. [4][5] …”

Section: Discussionmentioning

confidence: 99%

“…However, luxation or repositioning of the heart for assembly of coronary anastomoses can easily lead to a transient loss of signal, interrupting the continuous monitoring with these instruments. 5 …”

Section: Introductionmentioning

confidence: 99%

I.V. NIRS off-pump coronary artery ischemia monitoring bypass surgery

Tekalkote

Hussein

2018

Int Surg J

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INTRODUCTIONNear-infrared (NIR) spectroscopy is an appropriate method for ischemia monitoring in myocardial tissue. 1 An acute deterioration of coronary blood supply can result in a release of ischemic metabolites, predominantly oxygen-dependent chromophores into the coronary sinus. These metabolites are detectable in the coronary sinus blood, often prior to the appearance of substances representing cellular injury such as troponins and creatine kinase (CK-MB) in the peripheral blood. The online intravascular NIR spectroscopic analysis of the coronary sinus blood with a fiberoptic catheter allows a direct ischemia monitoring at myocardial level. 2 The aim of present study was to evaluate the clinical reliability of myocardial ischemia monitoring by using intravascular NIR spectroscopy in OPCAB surgery. The intraoperative management of hemodynamic changes in off-pump ABSTRACT Background: Spectroscopic data were compared with hemodynamic parameters, electrocardiogram, transesophageal echocardiography and laboratory findings. A conversion to extracorporeal circulation was not necessary. The mean number of grafts per patient was 3.1±0.6. An intraoperative myocardial ischemia was not evident, as indicated by electrocardiogram and transesophageal echocardiography. Methods: Continuous spectroscopic analysis showed reproducible absorption spectra of coronary sinus blood. Due to uneventful intraoperative courses, clear ischemia-related changes could be detected in none of the patients. Present initial results show that intravascular near-infrared spectroscopy can reliably be used for an online intraoperative ischemia monitoring in off-pump coronary artery bypass surgery. Results: In 15 elective patients undergoing off-pump myocardial revascularization, intravascular near-infrared spectroscopic analysis of coronary venous blood was performed. NIR signals were transferred through a fiberoptic catheter for signal emission and collection. For data analysis and processing, a miniature spectrophotometer with multivariate statistical package was used. Signal acquisition and analysis were performed before and after revascularization. However, the method has to be further evaluated and standardized to determine the role of spectroscopy in off-pump coronary artery bypass surgery. In off-pump coronary artery bypass surgery, manipulations on the beating heart can lead to transient interruptions of myocardial oxygen supply, which can generate an accumulation of oxygen-dependent metabolites in coronary venous blood. Conclusions: The objective of this study was to evaluate the reliability of intravascular near-infrared spectroscopy as a monitoring method to detect possible ischemic events in off-pump coronary artery bypass procedures.

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Mapping regional oxygenation and flow in pig hearts in vivo using near-infrared spectroscopic imaging

Cited by 36 publications

References 23 publications

Characterization of cryoinjury-induced infarction with manganese-and gadolinium-enhanced MRI and optical spectroscopy in pig hearts

Characterization of cryoinjury-induced infarction with manganese-and gadolinium-enhanced MRI and optical spectroscopy in pig hearts

Defects in myoglobin oxygenation in KATP-deficient mouse hearts under normal and stress conditions characterized by near infrared spectroscopy and imaging

I.V. NIRS off-pump coronary artery ischemia monitoring bypass surgery

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