Aims: Determination of D variants is important for selection of blood products and to prevent anti-D-related hemolytic disease of the fetus and newborn. the prevalence of weak D phenotypes varies significantly among different ethnic populations. In Morocco, D variants have not been fully characterized. the purpose of this study was to determine prevalence of weak D among D negative and c/E+ blood donors and distribution of rhesus blood group antigens using serologic methods. Methods: A total of 15,865 blood samples from Moroccan blood donors were tested for D, c, c, E, e antigens by routine serologic methods. Among blood donors serologically D negative c+ and/or E+, 63 samples were tested for weak D by indirect antiglobuline test, enzymatic treated cells test and adsorption elution technique. results: Among 63 samples tested, 10 were positive by serologic methods