Mapping of Zebrafish Research: A Global Outlook

Kinth, Priyamvadah; Mahesh, G.; Panwar, Yatish

doi:10.1089/zeb.2012.0854

Cited by 78 publications

(70 citation statements)

References 9 publications

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“…The search period was limited to between 2004 and 2014, to be in agreement with the publication years of EDA studies evaluated in this review. Outcomes are in good agreement with a recent review that applied much more sophisticated search strategy [17], indicating the usefulness of WoS for a first evaluation of research areas. Among the research areas strongly related to EDA, toxicology (8.9%) and pharmacology (9.0%) were each referred by circa 9% of the publications, while environmental sciences and ecology (3.0%) and chemistry (1.9%) were referred by a lower percentage.…”

Section: Context and Objectives Of This Reviewsupporting

confidence: 86%

“…Following these ground-breaking studies, there was evident increase in the use of zebrafish in research [17], resulting in the sequencing of its genome [18], extensive information on its genetics, genomics, phenotypic and developmental biology [19], and the establishment of thousands of wildtype and transgenic zebrafish lines [20,21].…”

Section: Zebrafish Model and Bioassays In Edamentioning

confidence: 99%

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The value of zebrafish as an integrative model in effect-directed analysis - a review

et al. 2015

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Section: Context and Objectives Of This Reviewsupporting

confidence: 86%

Section: Zebrafish Model and Bioassays In Edamentioning

confidence: 99%

The value of zebrafish as an integrative model in effect-directed analysis - a review

et al. 2015

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“…(b)] in which D . rerio are the key research model (Kinth et al ., ). Further, approximately equal numbers of responses were received from laboratories ranked by size of standing broodstock (<500, <1000, <5000, <10 000 and >10 000 D .…”

Section: Methodsmentioning

confidence: 99%

International survey on the use and welfare of zebrafish Danio rerio in research

Lidster

Readman

Prescott

et al. 2017

Journal of Fish Biology

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A survey was conducted regarding zebrafish Danio rerio use for scientific research with a focus on: anaesthesia and euthanasia; housing and husbandry; breeding and production; refinement opportunities. A total of 98 survey responses were received from laboratories in 22 countries in Europe, North America, South America, Asia and Australia. There appears a clear and urgent need to identify the most humane methods of anaesthesia and euthanasia. Aversive responses to MS-222 were widely observed raising concerns about the use of this anaesthetic for D. rerio. The use of anaesthesia in fin clipping for genetic identification is widely practised and there appears to be an opportunity to further develop less invasive methods and refine this process. Optimization (and potentially standardization) of feeding is an area for further investigation. Given that diet and body condition can have such profound effects on results of experiments, differences in practice could have significant scientific implications. Further research into transition between dark and light phases in the laboratory appears to represent an opportunity to establish best practice. Plants and gravel were not considered practical by many laboratories. The true value and benefits need to be established and communicated. Overproduction is a concern both from ethical and financial viewpoints. There is an opportunity to further reduce wastage of D. rerio. There are clear concerns and opportunities for the scientific community to work together to further improve the welfare of these important laboratory models.

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“…Search string 6 was designed to obtain publications on methods that use non-mammalian animal models, especially zebrafish embryos. As scientific research using zebrafish as a model organism is just been growing in the past 10 years (Kinth et al, 2013), we expect that no relevant publication will be missed due to this restriction. The search was performed on the 22nd of April, which means that all publications that had been published until this date are considered in this literature review.…”

Section: Search In Web Of Sciencementioning

confidence: 99%

Literature review on in vitro and alternative Developmental Neurotoxicity (DNT) testing methods

Fritsche

Alm

Baumann

et al. 2015

EFSA Supporting Publications

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The goal of this systematic review performed under a contract with EFSA was the evaluation of information on assessment methods in the field of developmental neurotoxicity (DNT). Therefore, a systematic and comprehensive literature search and collection of scientific literature and all other relevant grey literature and website information (in English) from past 20 years until mid of April 2014 on the state of the art of in vivo DNT testing methods including novel and alternative non-mammalian models, in vitro test methods, in silico methods, read across and combination of testing methods in test batteries was performed. This systematic review identified a variety of methods covering early and later stages of neurodevelopment that have the ability to predict DNT of chemicals. Few in vivo models alternative to OECD TG 426 were identified. In general, the available published in vivo data is scattered and heterogeneous, making comparisons across exposure paradigms and compounds very difficult. Thus, to make more useful evaluations, publications with more consistent experimental designs are needed, and more focused in vivo-in vitro comparisons are needed to establish useful effect biomarkers and testing models. From the alternative methods, a testing strategy covering early and later neurodevelopmental stages (from stem cell to zebrafish larvae motor behaviour) can be assembled. For gaining regulatory acceptance, definition of biological application domains of alternative methods by performing e.g. in vitro -in vivo validation is needed. Moreover, protocols for cell-based and zebrafish assays need international standardization. With such standardized protocols, the test battery needs to be tested for its sensitivity and specificity by testing concentration-responses of known DNT positive and negative compounds across the different assays. Such data might then be used either for regulatory decision-making or compound prioritization in favour of a reduction of rodent guideline in vivo testing.

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Mapping of Zebrafish Research: A Global Outlook

Cited by 78 publications

References 9 publications

The value of zebrafish as an integrative model in effect-directed analysis - a review

The value of zebrafish as an integrative model in effect-directed analysis - a review

International survey on the use and welfare of zebrafish Danio rerio in research

Literature review on in vitro and alternative Developmental Neurotoxicity (DNT) testing methods

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