Mapping of quantitative trait loci affecting quality and production traits in egg layers

Tuiskula-Haavisto, Maria; Honkatukia, Mervi; Vilkki, Johanna; Koning, Dirk-Jan de; Schulman, Nina; Mäki‐Tanila, Asko

doi:10.1093/ps/81.7.919

Cited by 138 publications

(134 citation statements)

References 22 publications

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“…Recently, many researchers have sought correlations between markers of candidate genes and reproductive traits in chickens . The MTNR1A and MTNR1C genes studied in this paper are located on chromosome 4 to which highly significant QTL effects on production traits have been mapped in previous studies (Tuiskula-Haavisto et al, 2002). Chickens with the AG genotype at MTNR1C and FF at MTNR1A produced their first eggs earlier (but, perhaps consequentially, eggs of lower weight) and produced more eggs at 300 days of age than chickens with other genotypes.…”

Section: Discussionmentioning

confidence: 76%

Genetic effects of melatonin receptor genes on chicken reproductive traits

Li¹,

Zhang²,

Smith³

et al. 2013

Czech J. Anim. Sci.

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ABSTRACT:The melatonin receptors are G protein-coupled receptors (GPCR) that bind melatonin. Three types of melatonin receptors have been cloned. The MTNR1A (or Mel1A or MT1) and MTNR1B (or Mel1B or MT2) receptor subtypes are present in humans and other mammals, while an additional melatonin receptor subtype MTNR1C (or Mel1C or MT3) has been identified in amphibians and birds. Previous research has shown that the three common melatonin receptors regulate physiological processes, including seasonal reproduction and ovarian physiology. However, whether or not any polymorphisms of the different melatonin receptor subtypes are associated with reproductive traits in chickens is not known. In this study, we performed candidate gene analysis to identify single-nucleotide polymorphisms (SNPs) in the MTNR1A, MTNR1B, and MTNR1C genes in the Erlang Mountain Chicken population. SNP discovery was achieved by sequencing pooled DNA samples. Direct PCR-sequencing, PCR-SSCP/PCR-sequencing, and PCR-RFLP method were used to genotype the MTNR1A, MTNR1B, and MTNR1C genes, respectively. The GLM Procedure was used to estimate the statistical significance of association between genotypes at each locus and reproductive traits of chickens. In a sample of 460 chickens, four novel polymorphisms (JQ249890:g.384T>C, JQ249891:g.387T>C, JQ249894:g.63C>T, and JQ249896:g.294G>A) were detected in the melatonin receptor genes MTNR1A, MTNR1B, and MTNR1C, respectively. A statistically significant association (P < 0.01) was found between two SNPs (MTNR1A SNP, MTNR1C SNP) and reproductive traits: egg number at 300 days of age (EN) and age at first egg (AFE).

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Section: Discussionmentioning

confidence: 76%

Genetic effects of melatonin receptor genes on chicken reproductive traits

Li¹,

Zhang²,

Smith³

et al. 2013

Czech J. Anim. Sci.

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“…A number of QTL mapping studies have been performed on crosses between genetically and phenotypically divergent lines of chickens. These studies have focused on identifying QTL responsible for body weight [39,46,47,51,52,55], feed-efficiency [57], growth [7,20,27,55,57,62], carcass characteristics [12,23,24,56], and egg traits [27,39,44,54,59]. Other researchers have investigated specific candidate genes potentially associated with variation in traits relating to bone integrity [31,61].…”

Section: Discussionmentioning

confidence: 99%

Identification of quantitative trait loci associated with bone traits and body weight in an F2 resource population of chickens

2005

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-Bone fractures at the end of lay are a significant problem in egg-laying strains of hens. The objective of the current study was to identify quantitative trait loci (QTL) associated with bone mineralization and strength in a chicken resource population. Layer (White Leghorn hens) and broiler (Cobb-Cobb roosters) lines were crossed to generate an F2 population of 508 hens over seven hatches, and 26 traits related to bone integrity, including bone mineral density (BMD) and content (BMC), were measured. Genotypes of 120 microsatellite markers on 28 autosomal groups were determined, and interval mapping was conducted to identify QTL regions. Twenty-three tests representing three chromosomal regions (chromosomes 4, 10 and 27) contained significant QTL that surpassed the 5% genome-wise threshold, and 47 tests representing 15 chromosomes identified suggestive QTL that surpassed the 5% chromosome-wise threshold. Although no significant QTL influencing BMD and BMC were detected after adjusting for variation in body weight and egg production, multiple suggestive QTL were found. These results support previous experiments demonstrating an important genetic regulation of bone strength in chickens, but suggest the regulation may be due to the effects of multiple genes that each account for relatively small amounts of variation in bone strength.bone mineral density / chickens / QTL / osteoporosis

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“…This approach was used as an alternative to the classical suggestive threshold computed as 1/N where N is the number of autosomes [22]. Instead of using the consensus lengths (for the ratio of chromosomes and genome lengths), Tuiskula-Haavisto et al [40] used the length of the chromosome covered by markers as the numerator of this ratio, and the length of the genome covered by the markers they analysed as the denominator. Threshold P-values obtained using this method are also given in Table II but were not used in the analyses.…”

Section: Significance Thresholdsmentioning

confidence: 99%

A genome scan for quantitative trait loci affecting the Salmonella carrier-state in the chicken

et al. 2005

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-Selection for increased resistance to Salmonella colonisation and excretion could reduce the risk of foodborne Salmonella infection. In order to identify potential loci affecting resistance, differences in resistance were identified between the N and 6 1 inbred lines and two QTL research performed. In an F2 cross, the animals were inoculated at one week of age with Salmonella enteritidis and cloacal swabs were carried out 4 and 5 wk post inoculation (thereafter called CSW4F2 and CSW4F2) and caecal contamination (CAECF2) was assessed 1 week later. The animals from the (N × 6 1 ) × N backcross were inoculated at six weeks of age with Salmonella typhimurium and cloacal swabs were studied from wk 1 to 4 (thereafter called CSW1BC to CSW4BC). A total of 33 F 2 and 46 backcross progeny were selectively genotyped for 103 and 135 microsatellite markers respectively. The analysis used least-squares-based and non-parametric interval mapping. Two genome-wise significant QTL were observed on Chromosome 1 for CSW2BC and on Chromosome 2 for CSW4F2, and four suggestive QTL for CSW5F2 on Chromosome 2, for CSW5F2 and CSW2BC on chromosome 5 and for CAECF2 on chromosome 16. These results suggest new regions of interest and the putative role of SAL1.

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Mapping of quantitative trait loci affecting quality and production traits in egg layers

Cited by 138 publications

References 22 publications

Genetic effects of melatonin receptor genes on chicken reproductive traits

Genetic effects of melatonin receptor genes on chicken reproductive traits

Identification of quantitative trait loci associated with bone traits and body weight in an F2 resource population of chickens

A genome scan for quantitative trait loci affecting the Salmonella carrier-state in the chicken

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