Mapping a highly conserved linear neutralizing epitope at the N-terminus of the gD glycoprotein of bovine herpesvirus type I using a monoclonal antibody

The Immunology of Bovine Respiratory Disease

“…55 Thus, researchers have sought to identify epitopes on gD important for virus neutralization, several of which have been defined, including recently described highly conserved, neutralizing epitopes within the amino and carboxy termini of BHV-1 gD. 56,57 Experimental evidence indicates that BVDV envelope E2 is not only the major immunodominant glycoprotein but also the most variable for BVDV isolates. nAb induced against E2 after natural infection or after vaccination is considered protective against BVDV.…”