MAP, a protein interacting with a tumor suppressor, merlin, through the run domain

Lee, Il Kyu; Kim, Kyung-Soo; Kim, Hongtae; Lee, Joo Yong; Ryu, Chung Hun; Chun, Heung Jae; Lee, Kyoung‐Uk; Lim, Yejee; Kim, Young Hoon; Huh, Pil Woo; Lee, Kweon-Haeng; Han, Sang-Ick; Jun, Tae‐Youn; Rha, Hyoung Kyun

doi:10.1016/j.bbrc.2004.10.095

Cited by 15 publications

(10 citation statements)

References 32 publications

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“…Interestingly, a previous study found that the C allele of rs17001868 was associated with mammographically dense area and breast cancer risk in opposing directions of association. The direction of association of rs17001868, in the SGSM3 gene which may be involved in NF2-mediated growth suppression of cells (30), to dense area in this study was similar to that reported previously.…”

Section: Discussionsupporting

confidence: 91%

Variants in 6q25.1 Are Associated with Mammographic Density in Malaysian Chinese Women

Mariapun

Kang

et al. 2016

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Mammographic density is an established risk factor for breast cancer and has a strong heritable component. Genome-wide association studies (GWAS) for mammographic density conducted in women of European descent have identified several genetic associations, but none of the studies have been tested in Asians. We sought to investigate whether these genetic loci, and loci associated with breast cancer risk and breast size, are associated with mammographic density in an Asian cohort.Methods: We conducted genotyping by mass spectrometry in 1,189 women (865 Chinese, 187 Indian, and 137 Malay). Quantitative measurements of mammographic density were performed using ImageJ, a fully automated thresholding technique. The associations of SNPs to densities were analyzed using linear regression models.Results: We successfully evaluated the associations of 36 SNPs with mammographic densities. After adjusting for age,

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Section: Discussionsupporting

confidence: 91%

Variants in 6q25.1 Are Associated with Mammographic Density in Malaysian Chinese Women

Mariapun

Kang

et al. 2016

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…The RUN domain containing proteins have been shown to promote endosomal fusion and are important for vesicular transport, and the RUN domains appear to be required for localization to detergent‐insoluble endosomal microdomains [36–38]. The physical interaction between RUN proteins and filamentous materials has been confirmed by pull‐down and two‐hybrid experiments using wild type and mutant proteins [39–41]. However, it is noteworthy that interaction with Rab (or Rap) is not the sole structural feature linking RUN proteins to vesicle traffic.…”

Section: Conclusion and Hypothetical Perspectivementioning

confidence: 99%

How do you RUN on?

et al. 2011

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a b s t r a c tRUN domain is present in several proteins related to the functions of Rap and Rab family GTPases. Accumulating evidence supports the hypothesis that RUN domain-containing proteins act as a component of vesicle traffic and might be responsible for an interaction with a filamentous network linked to actin cytoskeleton or microtubules. That is to say, on one hand, RUN domains associate with Rab or Rap family proteins, on the other hand, they also might interact with motor proteins such as kinesin or myosin via intervention molecules. In this review, we summarize the background and current status of RUN domain research with an emphasis on the interaction between RUN domain and motor proteins with respect to the vesicle traffic on filamentous network.

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“…The SGSM3 belongs to a novel protein family consisting of three members and appears to be associated with small G-protein coupled receptor signal transduction pathways, and could control cellular functions by a Ras-mediated signaling pathway[ 81 ]. Studies have linked Rab dysfunction to various human diseases including cancer[ 82 , 83 ], and our results have shown that the Ins allele might also be associated with death risk prior to 8 years.…”

Section: Discussionmentioning

confidence: 54%

Association of insertion-deletions polymorphisms with colorectal cancer risk and clinical features

Marques

Ferreira-Costa

Corrêa³

et al. 2017

WJG

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AIMTo investigate the association between 16 insertion-deletions (INDEL) polymorphisms, colorectal cancer (CRC) risk and clinical features in an admixed population.METHODSOne hundred and forty patients with CRC and 140 cancer-free subjects were examined. Genomic DNA was extracted from peripheral blood samples. Polymorphisms and genomic ancestry distribution were assayed by Multiplex-PCR reaction, separated by capillary electrophoresis on the ABI 3130 Genetic Analyzer instrument and analyzed on GeneMapper ID v3.2. Clinicopathological data were obtained by consulting the patients’ clinical charts, intra-operative documentation, and pathology scoring.RESULTSLogistic regression analysis showed that polymorphism variations in IL4 gene was associated with increased CRC risk, while TYMS and UCP2 genes were associated with decreased risk. Reference to anatomical localization of tumor Del allele of NFKB1 and CASP8 were associated with more colon related incidents than rectosigmoid. In relation to the INDEL association with tumor node metastasis (TNM) stage risk, the Ins alleles of ACE, HLAG and TP53 (6 bp INDEL) were associated with higher TNM stage. Furthermore, regarding INDEL association with relapse risk, the Ins alleles of ACE, HLAG, and UGT1A1 were associated with early relapse risk, as well as the Del allele of TYMS. Regarding INDEL association with death risk before 10 years, the Ins allele of SGSM3 and UGT1A1 were associated with death risk.CONCLUSIONThe INDEL variations in ACE, UCP2, TYMS, IL4, NFKB1, CASP8, TP53, HLAG, UGT1A1, and SGSM3 were associated with CRC risk and clinical features in an admixed population. These data suggest that this cancer panel might be useful as a complementary tool for better clinical management, and more studies need to be conducted to confirm these findings.

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MAP, a protein interacting with a tumor suppressor, merlin, through the run domain

Cited by 15 publications

References 32 publications

Variants in 6q25.1 Are Associated with Mammographic Density in Malaysian Chinese Women

Variants in 6q25.1 Are Associated with Mammographic Density in Malaysian Chinese Women

How do you RUN on?

Association of insertion-deletions polymorphisms with colorectal cancer risk and clinical features

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