Manuka honey‐impregnated dressings in the treatment of neuropathic diabetic foot ulcers

Kamaratos, A.; Tzirogiannis, Konstantinos; Iraklianou, Stella; Panoutsopoulos, Georgios I.; Kanellos, Ilias E.; Melidonis, Andreas

doi:10.1111/j.1742-481x.2012.01082.x

Cited by 104 publications

(78 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, clinical treatments with compounds, such as cadexomer iodine and medical-grade honey, are usually administered for weeks, and the applications are repeatedly replaced with fresh dressings within the treatment period (85)(86)(87)(88). Consequently, while the effect may appear limited, this does not account for the repeated and lengthy exposure that would occur in clinical cases.…”

Section: Resultsmentioning

confidence: 99%

Hyperosmotic Agents and Antibiotics Affect Dissolved Oxygen and pH Concentration Gradients in Staphylococcus aureus Biofilms

Kiamco

Atçı

Mohamed

et al. 2017

Appl Environ Microbiol

View full text Add to dashboard Cite

Biofilms on wound surfaces are treated topically with hyperosmotic agents, such as medical-grade honey and cadexomer iodine; in some cases, these treatments are combined with antibiotics. Tissue repair requires oxygen, and a low pH is conducive to oxygen release from red blood cells and epithelialization. We investigated the variation of dissolved oxygen concentration and pH with biofilm depth and the variation in oxygen consumption rates when biofilms are challenged with medical-grade honey or cadexomer iodine combined with vancomycin or ciprofloxacin. Dissolved oxygen and pH depth profiles in Staphylococcus aureus biofilms were measured using microelectrodes. The presence of cadexomer iodine with vancomycin or ciprofloxacin on the surface of the biofilm permitted a measurable concentration of oxygen at greater biofilm depths (101.6 Ϯ 27.3 m, P ϭ 0.02; and 155.5 Ϯ 27.9 m, P ϭ 0.016, respectively) than in untreated controls (30.1 m). Decreases in pH of ϳ0.6 and ϳ0.4 units were observed in biofilms challenged with medical-grade honey alone and combined with ciprofloxacin, respectively (P Ͻ 0.001 and 0.01, respectively); the number of bacteria recovered from biofilms was significantly reduced (1.26 log) by treatment with cadexomer iodine and ciprofloxacin (P ϭ 0.002) compared to the untreated control. Combining cadexomer iodine and ciprofloxacin improved dissolved oxygen concentration and penetration depth into the biofilm, while medical-grade honey was associated with a lower pH; not all treatments established a bactericidal effect in the time frame used in the experiments.IMPORTANCE Reports about using hyperosmotic agents and antibiotics against wound biofilms focus mostly on killing bacteria, but the results of these treatments should additionally be considered in the context of how they affect physiologically important parameters, such as oxygen concentration and pH. We confirmed that the combination of a hyperosmotic agent and an antibiotic results in greater dissolved oxygen and reduced pH within an S. aureus biofilm.

show abstract

Section: Resultsmentioning

confidence: 99%

Hyperosmotic Agents and Antibiotics Affect Dissolved Oxygen and pH Concentration Gradients in Staphylococcus aureus Biofilms

Kiamco

Atçı

Mohamed

et al. 2017

Appl Environ Microbiol

View full text Add to dashboard Cite

show abstract

“…Recently, the potent activity of honey against antibiotic-resistant bacteria has further increased the interest for application of honey. Several honeys have been approved for clinical application [4][5][6]. A review of different antibacterial studies showed that the antibacterial properties of honey depend on the geographical origin of the honey [7] Honey bees has been traditionally recognized as valuable source of energy which contains antibacterial and antifungal proprieties [8].…”

Section: Introductionmentioning

confidence: 99%

Colour Intensity, Polyphenol Content and Antibacterial Capacity of Unheated and Heat-Treated Sahara Honey

Ahmed¹,

Khiati²,

Saad³

et al. 2016

J Food Process Technol

View full text Add to dashboard Cite

The objective of this research work was to evaluate the effect of heat processing on antibacterial capacity of Sahara honey (SH). Various thermal treatments were carried out at 25°C, 50°C, 75°C and 100°C for 15 min, 30 min, and 60 min, and the parameters were determined: colour intensity, phenolic contents and antibacterial activity of two species of bacteria (Staphylococcus aureus and Pseudomonas aeruginosa). The total phenolic contents in honey samples varied from 0.55 and 1.54 mg of gallic acid equivalent (GAE) in gram of honey. MIC values respectively 3.12 to 12.5 mg/ml and zone of growth inhibition respectively 2.65 mm to 19 mm. Exposures of SH at 75°C and 100°C, no inhibition of Staphylococcus aureus and Pseudomonas aeruginosa growth was detected. Statistical analysis demonstrated positive correlations between color intensity and polyphenol contents and negative correlations with antibacterial capacity. Data from present results revealed that unheated and heat-treated Sahara honey showed growth inhibitory effect against Staphylococcus aureus and Pseudomonas aeruginosa with variable degrees.

show abstract

“…Viscosity of local honey can fix sucking cups during applying them to skin surface. Honey has strong antibacterial and antibiotic effects that promote wound healing [113,114].…”

Section: Nbmentioning

confidence: 99%

Therapeutic Benefits of Al-hijamah: in Light of Modern Medicine and Prophetic Medicine

Sayed¹,

Al-quliti²,

Mahmoud³

et al. 2014

AJMBR

View full text Add to dashboard Cite

Excretory treatment modalities that excrete pathological substances outside human body deserve more research attention as this may potentiate the therapeutic effects of pharmacological treatments. Overcoming language barrier through translating the national medical literature to medical English to be introduced to the international medical literature is vital. Wet cupping therapy (WCT) of prophetic medicine (Al-hijamah) is practiced in the Arabic medical literature where it is reported to treat many diseases differing in etiology and pathogenesis. Al-hijamah may be referred to as bloodletting cupping therapy or blood cupping therapy in medical studies and reports from Arabic countries. Both Chinese dry cupping therapy and WCT are partial steps of Al-hijamah. In this article, we review scientific principles, methodology, indications and therapeutic benefits of Al-hijamah in comparison with acupuncture and other types of cupping therapy. Scientific and medical bases of Al-hijamah were recently reported in the evidence-based Taibah mechanism (Taibah theory) where Al-hijamah is the only excretory treatment that clears blood, lymph and intercellular fluids from causative pathological substances (CPS). Al-hijamah benefits from the histological structure of the skin in performing a percutaneous pressure-dependent and size-dependent nonspecific blood filtration and excretion of CPS through the fenestrated skin capillaries upon application of negative pressure suction using sucking cups. Al-hijamah benefits also from the production of endogenous nitric oxide (vasodilator, antineoplastic and antimicrobial agent). Al-hijamah exerts many other health benefits e.g. enhancement of immunity and pharmacological potentiation. Al-hijamah was reported to clear blood significantly from serum triglycerides, total cholesterol, LDL-cholesterol, ferritin (circulating iron stores), uric acid, autoantibodies, cytokine receptors and others. Those therapeutic benefits may treat some diseases e.g. hyperlipidemia, hypertension, atherosclerosis, coronary heart diseases, gout, musculoskeletal pain conditions, hepatitis and iron overload conditions e.g. thalassemia. Importance of Al-hijamah may increase more in modern societies due to western diets and western life style. Therapeutic benefits of Al-hijamah are mainly related to the amount of excreted CPS not the amount of letted blood. Al-hijamah may carry some advantages better than acupuncture and other types of cupping therapy in treating a large number of diseases differing in etiology and pathogenesis.

show abstract

Manuka honey‐impregnated dressings in the treatment of neuropathic diabetic foot ulcers

Cited by 104 publications

References 44 publications

Hyperosmotic Agents and Antibiotics Affect Dissolved Oxygen and pH Concentration Gradients in Staphylococcus aureus Biofilms

Hyperosmotic Agents and Antibiotics Affect Dissolved Oxygen and pH Concentration Gradients in Staphylococcus aureus Biofilms

Colour Intensity, Polyphenol Content and Antibacterial Capacity of Unheated and Heat-Treated Sahara Honey

Therapeutic Benefits of Al-hijamah: in Light of Modern Medicine and Prophetic Medicine

Contact Info

Product

Resources

About