Manufacturing prototypes for paper-based diagnostic devices

Mace, Charles R.; Deraney, Rachel N.

doi:10.1007/s10404-013-1314-6

Cited by 48 publications

(35 citation statements)

References 60 publications

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“…Paper‐based analytical devices have been increasingly utilized as low cost and user‐friendly point‐of‐care (POC) diagnostic tools . Given the availability of high throughput printers, such devices are also amenable to rapid and scalable manufacturing, and can be set up to perform miniaturized tests. Until now, the vast majority of paper‐based sensors have relied on protein‐based assays utilizing enzymes and antibodies, or used nucleic acid hybridization to detect DNA .…”

Section: Figurementioning

confidence: 99%

A Paper Sensor Printed with Multifunctional Bio/Nano Materials

Hui

Liu

et al. 2018

Angew Chem Int Ed

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We report a paper-based aptasensor platform that uses two reaction zones and a connecting bridge along with printed multifunctional bio/nano materials to achieve molecular recognition and signal amplification. Upon addition of analyte to the first zone, a fluorescently labelled DNA or RNA aptamer is desorbed from printed graphene oxide, rapidly producing an initial fluorescence signal. The released aptamer then flows to the second zone where it reacts with printed reagents to initiate rolling circle amplification, generating DNA amplicons containing a peroxidase-mimicking DNAzyme, which produces a colorimetric readout that can be read in an equipment-free manner or with a smartphone. The sensor was demonstrated using an RNA aptamer for adenosine triphosphate (a bacterial marker) and a DNA aptamer for glutamate dehydrogenase (Clostridium difficile marker) with excellent sensitivity and specificity. These targets could be detected in spiked serum or feacal samples, demonstrating the potential for testing clinical samples.

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Section: Figurementioning

confidence: 99%

A Paper Sensor Printed with Multifunctional Bio/Nano Materials

Hui

Liu

et al. 2018

Angew Chem Int Ed

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“…Readout of lateral ow devices has evolved from using manual visual analysis to instrumented and automated readout, 193 but for fully integrated paper-based diagnostics with printed functionality, microuidics and electronics need to be combined on the same paper substrate. As each of these aspects is suited to different paper characteristics, 194,195 substrate pre-treatment and modication, 196 substrate integration, 197 and various printing and patterning techniques to optimize both electronic and uidic performance 41,145,[198][199][200] have been investigated.…”

Section: Integrationmentioning

confidence: 99%

The potential of paper-based diagnostics to meet the ASSURED criteria

et al. 2018

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“…It was first reported by Lu et al to fabricate paper microfluidic devices with filter paper for bioassays or nitrocellulose membrane for immunoassay. [1,7a,8b,11] According to literature survey, around 40% publications of paper microfluidics used wax printing for devices fabrication . Wax was chosen as an attractive alternative to SU‐8 or PDMS due to its extremely low‐cost and environment‐friendly characteristics .…”

Section: Fabrication Methods For Paper‐based Microfluidicsmentioning

confidence: 99%

Paper Microfluidics for Cell Analysis

Yan

Miao

et al. 2018

Adv Healthcare Materials

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Paper microfluidics has attracted much attention since its first introduction around one decade ago due to the merits such as low cost, ease of fabrication and operation, portability, and facile integration with other devices. The dominant application for paper microfluidics still lies in point‐of‐care testing (POCT), which holds great promise to provide diagnostic tools to meet the ASSURED criteria. With micro/nanostructures inside, paper substrates provide a natural 3D scaffold to mimic native cellular microenvironments and create excellent biointerfaces for cell analysis applications, such as long‐term 3D cell culture, cell capture/phenotyping, and cell‐related biochemical analysis (small molecules, protein DNA, etc.). This review summarizes cell‐related applications based on various engineered paper microdevices and provides some perspectives for paper microfluidics‐based cell analysis.

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Manufacturing prototypes for paper-based diagnostic devices

Cited by 48 publications

References 60 publications

A Paper Sensor Printed with Multifunctional Bio/Nano Materials

A Paper Sensor Printed with Multifunctional Bio/Nano Materials

The potential of paper-based diagnostics to meet the ASSURED criteria

Paper Microfluidics for Cell Analysis

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