Manufacturing of hydrogel biomaterials with controlled mechanical properties for tissue engineering applications

Vedadghavami, Armin; Minooei, Farnaz; Mohammadi, Mohammad Hossein; Khetani, Sultan; Kolahchi, Ahmad Rezaei; Mashayekhan, Shohreh; Sanati‐Nezhad, Amir

doi:10.1016/j.actbio.2017.07.028

Cited by 375 publications

(281 citation statements)

References 268 publications

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“…The literature in this field states that the Young's modulus of cartilage lies in the range of 0.1 to 2.1 MPa depending on the location. Much of the cartilage mimicking materials in the literature are able to closely replicate or encompass this range within the material property range . Although most of this comparative literature refers to the compressive modulus of either cartilage or the cartilage mimicking material is it difficult to comment on the compressive properties of our SAP:GAG gels as we only studied the shear properties of our gels.…”

Section: Rheologymentioning

confidence: 99%

On the design and efficacy assessment of self‐assembling peptide‐based hydrogel‐glycosaminoglycan mixtures for potential repair of early stage cartilage degeneration

Barco

Ingham

Fisher

et al. 2018

Journal of Peptide Science

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Peptide-based hydrogels are of interest for their potential use in regenerative medicine. Combining these hydrogels with materials that may enhance their physical and biological properties, such as glycosaminoglycans, has the potential to extend their range of biomedical applications, for example in the repair of early cartilage degeneration. The aim of this study was to combine three self-assembling peptides (P -4, P -8, and P -12) with chondroitin sulphate at two molar ratios of 1:16 and 1:64 in 130 and 230 mM Na salt concentrations. The study investigates the effects of mixing self-assembling peptide and glycosaminoglycan on the physical and mechanical properties at 37°C. Peptide alone, chondroitin sulphate alone, and peptide in combination with chondroitin sulphate were analysed using Fourier transform infrared spectroscopy to determine the β-sheet percentage, transmission electron microscopy to determine the fibril morphology, and rheology to determine the elastic and viscous modulus of the materials. All of the variables (peptide, salt concentration, and chondroitin sulphate molar ratio) had an effect on the mechanical properties, β-sheet formation, and fibril morphology of the hydrogels. P -4 and P -8-chondroitin sulphate mixtures, at both molar ratios, were shown to have a high β-sheet percentage, dense entangled fibrillar networks, as well as high mechanical stiffness in both (130 and 230 mM) Na salt solutions when compared with the P -12/chondroitin sulphate mixtures. These peptide/chondroitin sulphate hydrogels show promise for biomedical applications in glycosaminoglycan depleted tissues.

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Section: Rheologymentioning

confidence: 99%

On the design and efficacy assessment of self‐assembling peptide‐based hydrogel‐glycosaminoglycan mixtures for potential repair of early stage cartilage degeneration

Barco

Ingham

Fisher

et al. 2018

Journal of Peptide Science

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“…Owing to their high elasticity and softness, biocompatibility, and multifunctionality, [1] hydrogels have been applied in various fields, such as bioengineering, [2][3][4] smart devices, [5][6][7][8] soft robotics, [9][10][11] and agriculture. Owing to their high elasticity and softness, biocompatibility, and multifunctionality, [1] hydrogels have been applied in various fields, such as bioengineering, [2][3][4] smart devices, [5][6][7][8] soft robotics, [9][10][11] and agriculture.…”

Section: Introductionmentioning

confidence: 99%

3D Printing of Multifunctional Hydrogels

Chen

Zhao

Liu

et al. 2019

Adv Funct Materials

250

191

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3D printing technology has been widely explored for the rapid design and fabrication of hydrogels, as required by complicated soft structures and devices. Here, a new 3D printing method is presented based on the rheology modifier of Carbomer for direct ink writing of various functional hydrogels. Carbomer is shown to be highly efficient in providing ideal rheological behaviors for multifunctional hydrogel inks, including double network hydrogels, magnetic hydrogels, temperature-sensitive hydrogels, and biogels, with a low dosage (at least 0.5% w/v) recorded. Besides the excellent printing performance, mechanical behaviors, and biocompatibility, the 3D printed multifunctional hydrogels enable various soft devices, including loadable webs, soft robots, 4D printed leaves, and hydrogel Petri dishes. Moreover, with its unprecedented capability, the Carbomer-based 3D printing method opens new avenues for bioprinting manufacturing and integrated hydrogel devices.

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“…Polymeric scaffolds can be engineered using hydrogels that are made up of highly hydrophilic and crosslinked three-dimensional (3D) polymer networks [7,8,9]. However, traditional hydrogels often exhibit a nanoporous network that can limit cell motility, proliferation, and survival, as well as poor mechanical flexibility [10,11,12,13,14,15]. On the other hand, cryogels, a unique class of hydrogels prepared via cryopolymerization, exhibit large tunable interconnected macropores, high elasticity, and flexibility [15,16,17,18,19].…”

Section: Introductionmentioning

confidence: 99%

Injectable Hyaluronic Acid-co-Gelatin Cryogels for Tissue-Engineering Applications

et al. 2018

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Polymeric scaffolds such as hydrogels can be engineered to restore, maintain, or improve impaired tissues and organs. However, most hydrogels require surgical implantation that can cause several complications such as infection and damage to adjacent tissues. Therefore, developing minimally invasive strategies is of critical importance for these purposes. Herein, we developed several injectable cryogels made out of hyaluronic acid and gelatin for tissue-engineering applications. The physicochemical properties of hyaluronic acid combined with the intrinsic cell-adhesion properties of gelatin can provide suitable physical support for the attachment, survival, and spreading of cells. The physical characteristics of pure gelatin cryogels, such as mechanics and injectability, were enhanced once copolymerized with hyaluronic acid. Reciprocally, the adhesion of 3T3 cells cultured in hyaluronic acid cryogels was enhanced when formulated with gelatin. Furthermore, cryogels had a minimal effect on bone marrow dendritic cell activation, suggesting their cytocompatibility. Finally, in vitro studies revealed that copolymerizing gelatin with hyaluronic acid did not significantly alter their respective intrinsic biological properties. These findings suggest that hyaluronic acid-co-gelatin cryogels combined the favorable inherent properties of each biopolymer, providing a mechanically robust, cell-responsive, macroporous, and injectable platform for tissue-engineering applications.

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Manufacturing of hydrogel biomaterials with controlled mechanical properties for tissue engineering applications

Cited by 375 publications

References 268 publications

On the design and efficacy assessment of self‐assembling peptide‐based hydrogel‐glycosaminoglycan mixtures for potential repair of early stage cartilage degeneration

On the design and efficacy assessment of self‐assembling peptide‐based hydrogel‐glycosaminoglycan mixtures for potential repair of early stage cartilage degeneration

3D Printing of Multifunctional Hydrogels

Injectable Hyaluronic Acid-co-Gelatin Cryogels for Tissue-Engineering Applications

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