Manufacturing micro/nano chitosan/chondroitin sulfate curcumin-loaded hydrogel in ionic liquid: A new biomaterial effective against cancer cells

Caldas, Bárbara Sthéfani; Nunes, Cátia S.; Panice, Manuela Ribeiro; Scariot, Débora B.; Nakamura, Celso Vataru; Muniz, Edvani C.

doi:10.1016/j.ijbiomac.2021.02.194

Cited by 22 publications

(14 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Furthermore, the micronano chitosan/chondroitin sulfate curcumin-loaded hydrogel formed by polyelectrolytic complexation is a novel kind of anti-tumor biomaterial. Polyelectrolytic complexation actively released chitosan, curcumin and chondroitin sulfate, and cytotoxicity studies manifested that polyelectrolytic complexation containing curcumin had an excellent anti-tumor efficacy, promoting apoptosis of HeLa cancer cells ( Caldas et al, 2021 ). However, chitosan, HA, chondroitin sulfate and other natural polymers have poor mechanical properties, which affect the mechanical integrity of their composite scaffolds and impede their individual usage ( Abbas et al, 2020 ).…”

Section: Empirical Sci Treatment Involving Biomaterial-based Tlr4-nf-...mentioning

confidence: 99%

Strategies for Biomaterial-Based Spinal Cord Injury Repair via the TLR4-NF-κB Signaling Pathway

Shen

Cheng

et al. 2022

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

The repair and motor functional recovery after spinal cord injury (SCI) has remained a clinical challenge. Injury-induced gliosis and inflammation lead to a physical barrier and an extremely inhibitory microenvironment, which in turn hinders the recovery of SCI. TLR4-NF-κB is a classic implant-related innate immunomodulation signaling pathway and part of numerous biomaterial-based treatment strategies for SCI. Numerous experimental studies have demonstrated that the regulation of TLR4-NF-κB signaling pathway plays an important role in the alleviation of inflammatory responses, the modulation of autophagy, apoptosis and ferroptosis, and the enhancement of anti-oxidative effect post-SCI. An increasing number of novel biomaterials have been fabricated as scaffolds and carriers, loaded with phytochemicals and drugs, to inhibit the progression of SCI through regulation of TLR4-NF-κB. This review summarizes the empirical strategies for the recovery after SCI through individual or composite biomaterials that mediate the TLR4-NF-κB signaling pathway.

show abstract

Section: Empirical Sci Treatment Involving Biomaterial-based Tlr4-nf-...mentioning

confidence: 99%

Strategies for Biomaterial-Based Spinal Cord Injury Repair via the TLR4-NF-κB Signaling Pathway

Shen

Cheng

et al. 2022

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

show abstract

“…Luas permukaan sampel diukur berdasarkan jumlah molekul yang teradsorpsi pada lapisan tunggal nanokitosan. Luas permukaan spesifik nanokitosan dihitung menggunakan metode Braunaeur-Emmet-Teller (BET) sedangkan distribusi ukuran pori dan volume pori dihitung menggunakan metode Barret-Joyner-Halenda (BJH) (Caldas et al, 2021).…”

Section: Adsorpsi-desorpsi Nitrogen (N2)unclassified

Utilization of Nanochitosan as Adsorbent of Mercury (Hg) in Gold Ore Processing Waste

Himawan

Darmokoesoemo²,

Ardiarto³

et al. 2022

Eksergi

View full text Add to dashboard Cite

Mercury pollution in gold ore processing wastewater can cause environmental and health problems. A large amount of mercury pollution causes neurological disease, paralysis, loss of sense of taste, irregular speech, and death. One effective method to reduce mercury amount in the environment is adsorption. Adsorption performance is affected by several factors such as surface area of material, deacetylation degree (DD), and adsorption condition, which is indicated by contact time and mercury concentration. Nanochitosan is used in this research. Effect of deacetylation degree (85%; 87%; 95%), contact time (30;60;90;120 minutes), and variation of mercury concentration (5;10;15;20;25;30 ppm) on adsorption performance was investigated in this research. Nanochitosan in this research is characterized by FTIR, SEM-EDX, BET-BJH, and pH PZC. AAS measures adsorption performance in this research. The result shows that nanochitosan, which has the best adsorption performance, is nanochitosan with a deacetylation degree of 95%, at a contact time of 60 minutes, and mercury concentration is 15 ppm.

show abstract

“…As shown in Figure 7C–D, the Nyquist diagram of carbon nanotubes shows that it can suppress high resistance, and this electrochemical behavior will not change after being embedded in the chitosan collective [70] . Curcumin, which is used for cancer cell apoptosis, is unstable in neutral and alkaline environments, but chitosan/chondroitin sulfate (CHT/CS) Curcumin‐loaded hydrogel can stabilize the conditions under which curcumin is located, thereby improving chemical stability [72a] . In terms of catalysis, nanomaterials used for catalysis will inevitably experience an irreversible decrease in catalytic activity.…”

Section: Influence Of Nanomaterials On the Properties Of Hydrogelsmentioning

confidence: 99%

Recent Developments of Nanomaterials in Hydrogels: Characteristics, Influences, and Applications

et al. 2021

View full text Add to dashboard Cite

In recent years, due to their good physical and chemical properties, nanocomposite hydrogels have shown great application potential in the fields of biomedicine, sensors, 3D printing, and water pollution control. Compared with pure polymer hydrogels, the superior performance of nanocomposite hydrogels is mainly due to the influence of nanomaterials on the internal structure and composition of the hydrogels. In this paper, starting from the basic properties required for practical applications of hydrogels, the influence of nanomaterials on the different properties of hydrogels is discussed. Meanwhile, this paper reviews the research status of nanocomposite hydrogels in different application fields, and emphasizes the challenges and development prospects of nanocomposite hydrogel applications.

show abstract

Manufacturing micro/nano chitosan/chondroitin sulfate curcumin-loaded hydrogel in ionic liquid: A new biomaterial effective against cancer cells

Cited by 22 publications

References 46 publications

Strategies for Biomaterial-Based Spinal Cord Injury Repair via the TLR4-NF-κB Signaling Pathway

Strategies for Biomaterial-Based Spinal Cord Injury Repair via the TLR4-NF-κB Signaling Pathway

Utilization of Nanochitosan as Adsorbent of Mercury (Hg) in Gold Ore Processing Waste

Recent Developments of Nanomaterials in Hydrogels: Characteristics, Influences, and Applications

Contact Info

Product

Resources

About