For the present work, polylactic acid yarn (140 denier) was used for the production of bandage. The physical properties of fabric were measured. Chitosan-sodium alginate, calcium alginate-sodium alginate polymer and their blends were coated separately on the bandage to incorporate wound healing, haemostatic, easy removal, biocompatibility and antibacterial property. The polymer-coated samples were subjected to scanning electron microscope (SEM) and Fourier transform infrared spectroscopy (FT-IR) analysis. Bacteria present in wound samples were found using different bio-chemical methods. Antibiotic drugs were selected based on the antibiotic sensitivity test. The polymer-coated bandages have been further immobilized with tetracycline, chloramphenicol and rifampin drug to increase the rate of wound healing and antibacterial activity. The drug-loaded samples were subjected to drug release study for about four days in a static condition. All coatings showed a continuous drug release for about four days. Further, the antibacterial activity of the drug-loaded and polymer-coated samples was evaluated against Staphylococcus aureus and Proteus bacteria. It is concluded that chitosan, sodium alginate and calcium alginate coated with tetracycline and chloramphenicol drug-immobilized bandages are highly effective against bacteria.