Development and characterization of polylactic acid bandage coated with biopolymers and drugs for wound healing

Abstract

For the present work, polylactic acid yarn (140 denier) was used for the production of bandage. The physical properties of fabric were measured. Chitosan-sodium alginate, calcium alginate-sodium alginate polymer and their blends were coated separately on the bandage to incorporate wound healing, haemostatic, easy removal, biocompatibility and antibacterial property. The polymer-coated samples were subjected to scanning electron microscope (SEM) and Fourier transform infrared spectroscopy (FT-IR) analysis. Bacteria present in wound samples were found using different bio-chemical methods. Antibiotic drugs were selected based on the antibiotic sensitivity test. The polymer-coated bandages have been further immobilized with tetracycline, chloramphenicol and rifampin drug to increase the rate of wound healing and antibacterial activity. The drug-loaded samples were subjected to drug release study for about four days in a static condition. All coatings showed a continuous drug release for about four days. Further, the antibacterial activity of the drug-loaded and polymer-coated samples was evaluated against Staphylococcus aureus and Proteus bacteria. It is concluded that chitosan, sodium alginate and calcium alginate coated with tetracycline and chloramphenicol drug-immobilized bandages are highly effective against bacteria.