Manual measurement of retinal bifurcation features

Al-Diri, Bashir; Hunter, Andrew; Steel, David; Habib, Maged

doi:10.1109/iembs.2010.5626639

Cited by 16 publications

(15 citation statements)

References 23 publications

(27 reference statements)

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“…Using the tool that was implemented and described in details in a previous study [1], 1200 vessels widths (600 arteries and 600 veins in total for both groups in pixels) and 400 branching angles (in degrees) in the corresponding junctions (200 for arteries and 200 for veins in total for both groups) were measured. Although many state-of-the-art automated tools have been proposed in literature, utilizing many different methods e.g.…”

Section: Widths and Anglesmentioning

confidence: 99%

Exploiting the Retinal Vascular Geometry in Identifying the Progression to Diabetic Retinopathy Using Penalized Logistic Regression and Random Forests

Leontidis

Al-Diri

Hunter

2016

Emerging Trends and Advanced Technologies for Computational Intelligence

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Many studies have been conducted,investigating the effects that diabetes has to the retinal vasculature. Identifying and quantifying the retinal vascular changes remains a very challenging task, due to the heterogeneity of the retina. Monitoring the progression requires follow-up studies of progressed patients, since human retina naturally adapts to many different stimuli, making it hard to associate any changes with a disease. In this novel study, data from twenty five diabetic patients, who progressed to diabetic retinopathy, were used. The progression was evaluated using multiple geometric features, like vessels widths and angles, tortuosity, central retinal artery and vein equivalent, fractal dimension, lacunarity, in addition to the corresponding descriptive statistics of them. A statistical mixed model design was used to evaluate the significance of the changes between two periods: three years before the onset of diabetic retinopathy and the first year of diabetic retinopathy. Moreover, the discriminative power of these features was evaluated using a random forests classifier and also a penalized logistic regression.The area under the ROC curve after running a ten-fold cross validation was 0.7925 and 0.785 respectively.

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Section: Widths and Anglesmentioning

confidence: 99%

Exploiting the Retinal Vascular Geometry in Identifying the Progression to Diabetic Retinopathy Using Penalized Logistic Regression and Random Forests

Leontidis

Al-Diri

Hunter

2016

Emerging Trends and Advanced Technologies for Computational Intelligence

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“…The junctions were labelled and measured using a semi-automated tool described in [33]. Using this tool, each junction is firstly labelled manually as being a vein or an artery and then in a second stage the calibre is determined by fitting a rectangle between the wall edges of each vessel.…”

Section: Toolsmentioning

confidence: 99%

“…In this experiment, the semi-automated tool described in [33] was used to manually label the arteries and veins. The methodology of Knudtson et al…”

Section: Analysis Of Avrmentioning

confidence: 99%

Summarising the retinal vascular calibres in healthy, diabetic and diabetic retinopathy eyes

Leontidis

Al-Diri

Hunter

2016

Computers in Biology and Medicine

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Retinal vessel calibre has been found to be an important biomarker of several retinal diseases, including diabetic retinopathy (DR). Quantifying the retinal vessel calibres is an important step for estimating the central retinal artery and vein equivalents. In this study, an alternative method to the already established branching coefficient(BC) is proposed for summarising the vessel calibres in retinal junctions. This new method combines the mean diameter ratio with an alternative to Murray's cube law exponent, derived by the fractal dimension,experimentally, and the branch exponent of cerebral vessels, as has been suggested in previous studies with blood flow modelling. For the above calculations, retinal images from healthy, diabetic and DR subjects were used. In addition, the above method was compared with the BC and was also applied to the evaluation of arteriovenous ratio as a biomarker of progression from diabetes to DR in four consecutive years, i.e. three/two/one years before the onset of DR and the first year of DR. Moreover, the retinal arteries and veins around the optic nerve head were also evaluated. The new approach quantifies the vessels more accurately. The decrease in terms of the mean absolute percentage error was between 0.24% and 0.49%, extending at the same time the quantification beyond healthy subjects.

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“…The branching angles and vessel segment calibers are used to derive features, such as the bifurcation index (quotient between the diameter of the smaller and larger branches), asymmetry ratio (cross-sectional area of the smaller branch divided by that of the larger), diameter ratio (branch diameter divided by trunk diameter), area ratio (sum of cross-sectional areas of two branches divided by that of the trunk) and optimality (deviation of the junction power law value from the optimal value) [3].…”

Section: Computation Of the Bifurcation Featuresmentioning

confidence: 99%

“…These diseases also change the pattern of vessel branching, thus making the measurement of bifurcation geometrical features a useful tool for the diagnosis or prediction of such pathologic conditions [3].…”

Section: Introductionmentioning

confidence: 99%

Computer-aided diagnosis system for the assessment of retinal vascular changes

Dashtbozorg

Mendonça

Penas

et al. 2014

Proceedings of the Ophthalmic Medical Image Analysis First International Workshop

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Abstract. This paper presents an automatic application that provides several retinal image analysis functionalities, namely vessel segmentation, vessel width estimation, artery/vein classification and optic disc segmentation. A pipeline of these methods allows the computation of important vessel related indexes, namely the Central Retinal Arteriolar Equivalent (CRAE), Central Retinal Venular Equivalent (CRVE) and Arteriolar-to-Venular Ratio (AVR), as well as various geometrical features associated with vessel bifurcations. The results for AVR estimation were assessed using the images of INSPIRE-AVR dataset; for this dataset, the mean error of the measured AVR values with respect to the reference was identical to the one achieved by a medical expert. The estimation of the CRAE, CRVE and AVR values on 480 images from 120 subjects have shown a significant correlation between right and left eyes and also between images of same eye acquired with different camera fields of view.

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Manual measurement of retinal bifurcation features

Cited by 16 publications

References 23 publications

Exploiting the Retinal Vascular Geometry in Identifying the Progression to Diabetic Retinopathy Using Penalized Logistic Regression and Random Forests

Exploiting the Retinal Vascular Geometry in Identifying the Progression to Diabetic Retinopathy Using Penalized Logistic Regression and Random Forests

Summarising the retinal vascular calibres in healthy, diabetic and diabetic retinopathy eyes

Computer-aided diagnosis system for the assessment of retinal vascular changes

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