“…In this context, the diagnosis of tuberculosis is established by a positive culture from body fluids or tissues, but may not be possible in some organs because of difficulties in non-invasive access or because of the inability to obtain results. In this case, the positivity of interferon-gamma release assays (IGRA) and tuberculin intradermal reaction at a threshold of 13 mm remains strongly associated with tuberculosis infection with a sensitivity of 54% and specificity of 90% [ 19 , 21 ].…”