Associated Risk Factors for Latent Tuberculosis Infection in Subjects with Diabetes

Martínez‐Aguilar, Gerardo; Serrano, Carmen; Castañeda-Delgado, Julio Enrique; Macías-Segura, N.; Hernández-Delgadillo, Nicolás; Enciso-Moreno, Leonor; Lira, Yolanda García de; Valenzuela-Méndez, Ema; Gándara-Jasso, Benjamín; Correa-Chacón, Joel; Bastián-Hernández, Y.; Rodríguez-Morán, Martha; Guerrero-Romero, Fernando; Enciso-Moreno, José Antonio

doi:10.1016/j.arcmed.2015.03.009

Cited by 29 publications

(24 citation statements)

References 38 publications

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“…The Present study, showed that in Diabteics 35.7% were positive for Latent Tuberculosis Infection (LTBI) and 12.2 % in non-diabetics were positive for LTBI. When compared with the studies from Mexico (50%), [11] Spain (42.2%) [12] , Puerto Rico (42.4%), this study revealed a lower prevalence in Diabetics; however, when compared to study from Asia pacific region the prevalence were higher to a Singaporean study (28.2%) [13] . This could be due to differences in the various cut-off values for TST that have been used, for example the Mexicans used 5mm as cut-off, whereas we used 10 mm based on WHO criteria.…”

Section: Discussioncontrasting

confidence: 67%

Prevalence of Latent Tuberculosis Infection in Type 2 Diabetic and NonDiabetic Individuals

Rajalakshmi¹

2017

jmscr

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Section: Discussioncontrasting

confidence: 67%

Prevalence of Latent Tuberculosis Infection in Type 2 Diabetic and NonDiabetic Individuals

Rajalakshmi¹

2017

jmscr

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“…In the medium-risk group, the prevalence of LTBI ranges between 33% and 87•6% [1,8,22,23], and the TB incidence rates between 9 and 5780 per 100 000 in healthcare workers [22], to 61 and 6799 per 100 000 in prisoners [1]. Among low-risk group, the prevalence of LTBI ranges between 28•2% and 51•3% [24,25], and the incidence of TB was 16•2 cases per 100 000 person-years in patients with diabetes [26].…”

Section: Tuberculous Infection (Arti) In Prisoners Was Higher Than Thmentioning

confidence: 99%

Negative latent tuberculosis at time of incarceration: identifying a very high-risk group for infection

et al. 2017

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The main aim was to measure the incidence of latent tuberculosis infection (LTBI) and identify risk factors associated with infection. In addition, we determined the number needed to screen (NNS) to identify LTBI and active tuberculosis. We followed 129 prisoners for 2 years following a negative two-step tuberculin skin test (TST). The cumulative incidence of TST conversion over 2 years was 29·5% (38/129), among the new TST converters, nine developed active TB. Among persons with no evidence of LTBI, the NNS to identify a LTBI case was 3·4 and an active TB case was 14·3. The adjusted risk factors for LTBI conversion were incarceration in prison number 1, being formerly incarcerated, and overweight. In conclusion, prisoners have higher risk of LTBI acquisition compared with high-risk groups, such as HIV-infected individuals and children for whom LTBI testing should be performed according to World Health Organization guidance. The high conversion rate is associated with high incidence of active TB disease, and therefore we recommend mandatory LTBI screening at the time of prison entry. Individuals with a negative TST at the time of entry to prison are at high risk of acquiring infection, and should therefore be followed in order to detect convertors and offer LTBI treatment. This approach has a very low NNS for each identified case, and it can be utilized to decrease development of active TB disease and transmission.

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“…Regarding the association between having had contact with a person infected with TB and the development of TB, shown in this study, other studies reiterate these results. In a cross-sectional study, diabetics living with relatives with TB were more positive reactors (≥ 5mm) to the tuberculin test, suggestive of latent TB infection, as compared to diabetics othrwise 24 . On the other hand, a retrospective cohort showed that individuals who had contact with people with TB were six times more likely to develop TB within two years when the tuberculin skin test ≥ 5mm 25 .…”

Section: Discussionmentioning

confidence: 91%

Fatores associados à tuberculose em população de diabéticos: um estudo caso-controle

Leal

Maciel

Cadê

2019

Ciênc. saúde coletiva

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Resumo Este estudo analisou os fatores associados à tuberculose em diabéticos atendidos nas unidades de saúde de Vitória/ES, Brasil. Trata-se de um estudo caso-controle, sendo 45 casos de diabéticos atendidos nas 30 unidades do município e notificados no SINAN com diagnóstico de tuberculose no período de 2007 a 2013 e 90 de controles diabéticos. Utilizaram-se dados do SINAN, do Sistema de Informação em Saúde de Vitória e do Laboratório Central Municipal, e uma entrevista estruturada. Foram realizadas análises bivariada e multivariada, mediante regressão logística com as variáveis significativas (p < 0,05). O grupo caso apresentou maior frequência de hábitos de vida danosos à saúde em comparação com o grupo controle, como consumo compulsivo de álcool (p < 0,001) e tabagismo (p = 0,060), além de piores parâmetros bioquímicos, como glicemia de jejum (p < 0,001) e hemoglobina glicosilada (p = 0,034). A ingestão regular de bebida alcoólica (OR 6,612; IC 2,151-20,330), o contato prévio com pessoas com tuberculose (OR 4,418; IC 1,678-11,631) e a glicemia de jejum (OR 1,017; IC 1,007-1,026) foram associados à tuberculose nos diabéticos. O estudo revela que piores hábitos de vida e controle glicêmico, e o contato anterior com tuberculose ativa aumentam a chance de o diabético desenvolver tuberculose.

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Associated Risk Factors for Latent Tuberculosis Infection in Subjects with Diabetes

Cited by 29 publications

References 38 publications

Prevalence of Latent Tuberculosis Infection in Type 2 Diabetic and NonDiabetic Individuals

Prevalence of Latent Tuberculosis Infection in Type 2 Diabetic and NonDiabetic Individuals

Negative latent tuberculosis at time of incarceration: identifying a very high-risk group for infection

Fatores associados à tuberculose em população de diabéticos: um estudo caso-controle

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