Mantoux and contact positivity in tuberculosis

Vijayasekaran, D; Kumar, R. Arvind; Gowrishankar, NC; Nedunchelian, K; Sethuraman, S.

doi:10.1007/bf02758303

Cited by 26 publications

(21 citation statements)

References 11 publications

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“…Vijaysekaran et al have found that in their study Mantoux positivity in childhood TB varies from 21.2% to 53%. 12 Sputum examination was found to be positive in 9 cases (10%) similar to other studies. Older children were significantly associated with positive AFB.…”

Section: Discussionsupporting

confidence: 88%

Profile and outcome of childhood tuberculosis treated with DOTS at a tertiary care hospital in central India: an observational study

Bharani

Harshey

Raipurkar

2018

Int J Contemp Pediatr

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Background: Children contribute a significant proportion of the tuberculosis (TB) burden in India and suffer severe TB related morbidity and mortality, particularly in endemic areas. Diagnosis and management of pediatric TB especially Extra pulmonary (EPTB) is challenging. The present study was designed to study clinical, laboratory characteristics and outcome of childhood tuberculosis.Methods: A retrospective analysis of 90 cases of TB in children within 2 year period was conducted at Pediatric Department and DOTS center at a tertiary care hospital from January 2015 to December 2016.Results: In the present study 20% of the total TB patients attending DOTS OPD were Children. Most common symptoms were Fever (53.3 %), Cough (46.6%), abdominal pain (18.8%), lymphadenopathy (13.3%), osteo-articular symptoms (13.3%), weight loss (10%), CNS related complaints like convulsions and unconsciousness (6.6%). History of contact was present in 10 cases (11%). Sputum examination was positive in 9 cases (10%) who were predominantly older children above 12 years. Mantoux test was positive in 9 cases (10%). Only one patient was HIV positive. Extra pulmonary tuberculosis (EPTB) patients were more common than pulmonary. 47 out of the 90 cases (52%) were receiving DOTS for EPTB. Out of the 90 cases 84 (93.3%) were on New Category 1 treatment and 6 (6.6%) were on Cat 2 treatment. Out of the total 90 cases 3 defaulted, 3 died, rest completed treatment with good compliance and no side-effects and were declared cured.Conclusions: In present study, it was found that extra-pulmonary tuberculosis (EPTB) patients are more common than pulmonary tuberculosis in pediatric age group. Sputum positivity yield is very low in pediatric age group. Success of treatment with DOTS is good (94.4%). No adverse effects of ATT were observed.

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Section: Discussionsupporting

confidence: 88%

Profile and outcome of childhood tuberculosis treated with DOTS at a tertiary care hospital in central India: an observational study

Bharani

Harshey

Raipurkar

2018

Int J Contemp Pediatr

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“…11 Turan SI et al and Flora AL observed that 30% and 38.8% cases of tuberculoma had abnormal chest radiograph suggestive of tuberculosis, found similar to 30.7% children with abnormal chest radiographs among tuberculoma in our study group. 12,13 Our study has conducted on diverse population from remote areas with poor medical facilities and low socio economic status who are mostly a BPL card holder limiting the emergent and non-urgent neuroimaging at the time admission and on follow up.…”

supporting

confidence: 83%

Neurocysticercosis: a commonest neuroimaging abnormalitiy in children with first afebrile seizure in central India

Agarwal

Lazarus

Roy

et al. 2016

Int J Contemp Pediatr

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Background: Seizures are the commonest neurological ailments in paediatrics in ~10%, even though the role of emergent neuroimaging in first onset afebrile seizure is not well defined.Methods: A prospective observational study was conducted in NSCB Medical College, Jabalpur, Madhya Pradesh, India to determine the incidence of neuroimaging abnormalities in children with first onset afebrile seizure and to make specific recommendations for use of routine neuroimaging in the new onset afebrile seizure. A total of 75 children (1 month to 14 years of age) with the new-onset afebrile seizure were enrolled and underwent clinical examination & neuroimaging. We defined first seizure using the international league against epilepsy (ILAE). The data were recorded and analysed by Student ‘t’ test for continuous variables, Fisher’s Exact Test or Chi square test for categorical variables. The critical level of significance was considered at P < 0.05 level.Results: Neuroimaging abnormalities were found in 66.7% of the cases, mostly in the children above 2 years of age (72.6 %) (P value <0.05). A significant relationship (P <0.001) was observed between focality (partial seizures (83.8%)) and abnormal neuroimaging, among these neurocysticercosis (26.7%) were in highest proportion with parietal lobe as the commonest involvement. The cases with contact history of tuberculosis /mantoux positivity/abnormal chest radiography were found significantly interrelated with tuberculoma (P <0.05).Conclusions: In developing countries like India the prevalence of neurocysticercosis and tuberculoma is high, hence neuroimaging in all cases of first onset afebrile seizure/ focal seizure with mantoux positive/ history of Contact /abnormal chest radiograph can be kept in a view for better management of child.

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“…Studies from India have reported culture positivity ranging from 32% to 37.7% [26][27][28] [30]. Higher rates in these studies have been attributed to the use of a combination of induced sputum and gastric lavage as specimens, as well as the use of a combination of one solid and one liquid medium.…”

Section: Discussionmentioning

confidence: 97%

Diagnosis of pediatric pulmonary tuberculosis with special reference to polymerase chain reaction based nucleic acid amplification test

Tiwari¹,

Nataraj²,

Kanade³

et al. 2015

International Journal of Mycobacteriology

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Mantoux and contact positivity in tuberculosis

Abstract: The study also reflects that the extra pulmonary forms of tuberculosis seems to be more common in the pediatric population which constituted 79.8% of the cases included in the study.

Cited by 26 publications

References 11 publications

Profile and outcome of childhood tuberculosis treated with DOTS at a tertiary care hospital in central India: an observational study

Profile and outcome of childhood tuberculosis treated with DOTS at a tertiary care hospital in central India: an observational study

Neurocysticercosis: a commonest neuroimaging abnormalitiy in children with first afebrile seizure in central India

Diagnosis of pediatric pulmonary tuberculosis with special reference to polymerase chain reaction based nucleic acid amplification test

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