Mantle Cell Lymphoma Superimposed on Multicentric Castleman's Disease

Yoshida, Toyonobu; Sakai, Akira; Imagawa, Jun; Noda, Matu-Tarow; Takada, Shinichi; Yoshino, Tadashi; Kimura, Akiro

doi:10.3960/jslrt.51.147

Cited by 5 publications

(5 citation statements)

References 3 publications

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“…There are several reports regarding a high IL-6 plasma level in tumors (14,16,19,20), hemophagocytic syndrome (21,22), and IVLBCL (11,23) or IL-6 positivity on immunohistochemistry staining (14,16,19,20,24). These cases also support the possibility that paraneoplastically produced IL-6 can induce an MCD-like clinical presentation.…”

Section: Discussionsupporting

confidence: 53%

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Interleukin-6-producing Intravascular Large B-cell Lymphoma with Lymphadenopathy Mimicking the Histology of Multicentric Castleman Disease

et al. 2020

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An inguinal lymph node biopsy of a woman with a one-month history of a progressive fever, fatigue, dyspnea, skin rash, and lymphadenopathy revealed a well-preserved basic structure, hyperplastic germinal centers, and an interfollicular region containing polyclonal plasma cell sheets, suggesting plasma cell-type multicentric Castleman disease (MCD). We initiated prednisolone and anti-interleukin (IL)-6 antibody (tocilizumab), without success. A biopsy specimen re-evaluation detected CD20-positive atypical large B cells infiltrating the small vessels within and around the lymph node and its capsule. We diagnosed her with intravascular large B-cell lymphoma (IVLBCL). Lymphoma cells were weakly positive for IL-6 by immunohistochemical staining. IL-6 from lymphoma cells may have caused the MCD-like presentation as a paraneoplastic etiology. Malignant lymphoma should be excluded before diagnosing MCD.

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Section: Discussionsupporting

confidence: 53%

“…Several malignant lymphoma cases with MCD histology have been reported. Interfollicular Hodgkin lymphoma (HL) is the most frequently reported (12-15), followed by non-Hodgkin lymphoma (NHL) (15)(16)(17)(18). In previous cases, concurrent MCD and lymphoma histology was observed.…”

Section: Discussionmentioning

confidence: 99%

Interleukin-6-producing Intravascular Large B-cell Lymphoma with Lymphadenopathy Mimicking the Histology of Multicentric Castleman Disease

et al. 2020

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“…Most of these studies were of the PC type. [10][11][12][13][14][15] In a 1995 study by Soulier, et al clonal IgH rearrangements were detected in 4 out of 34 CD patients using polymerase chain reaction and Southern blot analysis, and all of these cases were diagnosed in HIVnegative patients. Two of the latter cases were associated with non-Hodgkin B-cell lymphoma, one case with Hodgkin's lymphoma, and one case without malignancy.…”

Section: Discussionmentioning

confidence: 99%

<sup>Multicentric Castleman Disease with Monoclonal Incomplete IgH Restriction: A Rare Coexistence</sup>

Goyal

Kendric

Silberstein

et al. 2015

J Clin Exp Hematopathol

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Castleman disease is a rare lymphoproliferative disorder that may have a unicentric or multicentric clinical presentation. Herein we present the case of a 49-year-old female with a 3-year history of progressively worsening lymphadenopathy associated with fevers, chills and night sweats. Laboratory studies showed anemia and mildly elevated sedimentation rate. A computed tomogram scan of the chest, abdomen and pelvis showed multiple enlarged bilateral axillary, supraclavicular, subpectoral, submental, retroperitoneal, and para-aortic lymph nodes. A right axillary lymph node biopsy was performed and found to display histopathologic features compatible with the plasma cell type of Castleman disease. The patient was found to be human immunodeficiency virus (HIV)-positive, with a viral load of 104,000/mL and a CD4 cell count of 84 cells/mm(3). Molecular studies on the lymph node specimen revealed an incomplete monoclonal DH-JH rearrangement in the IgH gene. The patient was initially treated with antiretroviral therapy with a combination of elvitegravir, cobicistat, emtricitabine and tenofovir that improved her fatigue and malaise. As treatment for Castleman disease, she was administered a combination of rituximab and etoposide, which led to a reduction in lymphadenopathy. To the best of the authors' knowledge, this is the first reported case of multicentric Castleman disease with monoclonal incomplete IgH gene rearrangement in an HIV-positive patient.

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“…La EC se caracteriza por linfadenopatía, fiebre, hipergammaglobulinemia, frecuentemente los pacientes muestran anormalidades inmunológicas y desarrollan tumores secundarios 6 . Aun cuando la mayoría de las lesiones son de origen policlonal y se consideran reactivas, se ha informado que bajo ciertas circunstancias los pacientes con EC del tipo difuso de células plasmáticas pueden progresar hacia diferentes tipos de linfomas no Hodgkin de células B como: linfoma del manto 7 , linfoma folicular 8 , LCGB 1,9,10 , linfoma plasmablástico, linfoma primario de serosas y su variante sólida; así como linfoma de Hodgkin (LH) [11][12][13][14][15][16] . El HVSK/VHH8 codifica más de diez homólogos de genes celulares que regulan señales de proliferación celular y antiapoptóticas, que pudieran estar implicados en el desarrollo y progresión de estas neoplasias [17][18] .…”

Section: Discussionunclassified

Linfoma de células grandes B originado en enfermedad de Castleman. Reporte de un caso y revisión de la literatura

et al. 2017

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Mantle Cell Lymphoma Superimposed on Multicentric Castleman's Disease

Cited by 5 publications

References 3 publications

Interleukin-6-producing Intravascular Large B-cell Lymphoma with Lymphadenopathy Mimicking the Histology of Multicentric Castleman Disease

Interleukin-6-producing Intravascular Large B-cell Lymphoma with Lymphadenopathy Mimicking the Histology of Multicentric Castleman Disease

<sup>Multicentric Castleman Disease with Monoclonal Incomplete IgH Restriction: A Rare Coexistence</sup>

Linfoma de células grandes B originado en enfermedad de Castleman. Reporte de un caso y revisión de la literatura

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