Mantle-Cell Lymphoma in a Patient with Human Immunodeficiency Viral Infection

Abstract

Rare cases of low-grade lymphomas have been described in patients with human immunodeficiency virus (HIV) infection. However, this is the first reported case of mantle-cell lymphoma, a type of low-grade lymphoma, in a patient who also had HIV infection. Salient clinical features included lymphocytosis, lymphadenopathy, splenomegaly, and involvement of the bone marrow and meninges. The disease proved to be unusually aggressive and response to chemotherapy was insignificant. The patient survived only 4 months.

Mantle cell lymphoma in human immunodeficiency virus‐infected patients

“…Low-grade lymphomas are less common, and to our knowledge, only one HIV-associated MCL (HIV-MCL) case has been reported to date, in the pre-cART era. 5 Among the 976 patients with NHL enrolled in the HIVlymphoma cohort between June 1996 and June 2021 with a stable median enrolment of 35 NHL-HIV per year (21-49), eight patients (0.8%) were diagnosed with MCL (Table 1). The estimate incidence rate was 0.7/1000 patient-years during the 10 786 patient-years of observation time (Table S1).…”

“…The previously reported case in pre-cART era, also occurred in a patient with a long-lasting HIV infection (6 years) and a relatively high CD4 + T-cell count (0.36 × 10 9 /l). 5 Treatment of HIV-associated lymphoma has markedly improved during the last decades. Anti-retroviral therapyinduced immune restoration and decreased drug interactions allow a similar therapeutic approach of lymphoma in HIV-infected and uninfected patients.…”