Induction of interleukin-1 and glucocorticoid hormones by HIV promotes viral replication and links human chromosome 2 to AIDS pathogenesis: genetic mechanisms and therapeutic implications

Corley, P.A.

doi:10.1016/s0306-9877(97)90040-2

Cited by 11 publications

(3 citation statements)

References 47 publications

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“…It is hypothesised that a viral infection may represent the initial stimulus capable of inducing the upregulation of IL-1β. Among the viruses involved, there would be Kaposi's sarcoma-associated herpesvirus, Epstein-Barr virus, human immunodeficiency virus-1, and respiratory syncytial virus [99,100]. An interesting finding that could give a further potential explanation of the cytokine network that favors disease progression would be related to the increased expression of IL-2R on MM cells and to a lesser extent on MGUS cells, suggesting that progression from MGUS to MM is also related to the alteration of the IL-2/IL-2R system [101].…”

Section: Role Of the Immune System In MM Progressionmentioning

confidence: 99%

Involvement of Alarmins in the Pathogenesis and Progression of Multiple Myeloma

Murdaca

Allegra

Paladin

et al. 2021

IJMS

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Objective: Multiple Myeloma (MM) is a haematological disease resulting from the neoplastic transformation of plasma cells. The uncontrolled growth of plasma cells in the bone marrow and the delivery of several cytokines causes bone erosion that often does not regress, even in the event of disease remission. MM is characterised by a multi-step evolutionary path, which starts with an early asymptomatic stage defined as monoclonal gammopathy of undetermined significance (MGUS) evolving to overt disease. Data Sources and Study Selection: We have selected scientific publications on the specific topics “alarmis, MGUS, and MM”, drawing from PubMed. The keywords we used were alarmines, MGUS, MM, and immune system. Results: The analysis confirms the pivotal role of molecules such as high-mobility group box-1, heat shock proteins, and S100 proteins in the induction of neoangiogenesis, which represents a milestone in the negative evolution of MM as well as other haematological and non-haematological tumours. Conclusions: Modulation of the host immune system and the inhibition of neoangiogenesis may represent the therapeutic target for the treatment of MM that is capable of promoting better survival and reducing the risk of RRMM.

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Section: Role Of the Immune System In MM Progressionmentioning

confidence: 99%

Involvement of Alarmins in the Pathogenesis and Progression of Multiple Myeloma

Murdaca

Allegra

Paladin

et al. 2021

IJMS

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“…30 Although it has not been demonstrated for KSHV, Epstein-Barr virus (EBV), human immunodeficiency virus-1 (HIV-1) and respiratory syncytial virus (RSV) have been shown to up-regulate IL-1 expression either by directly interacting with genomic sequences or indirectly by altering levels of transcription factors involved in IL-1␤ expression. [31][32][33] If KSHV is involved in the pathogenesis of myeloma, it would not be unlikely that it could play a role either directly or indirectly in the aberrant expression of the IL-1␤ gene.…”

Section: Figurementioning

confidence: 99%

Contrast in cytokine expression between patients with monoclonal gammopathy of undetermined significance or multiple myeloma

et al. 1998

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We investigated whether differences in IL-6 and IL-1␤ expression could be detected in monoclonal plasma cells from patients with MGUS or MM. Expression of IL-6 and IL-1␤ in bone marrow cells was determined using cell sorting to enrich for plasma cells followed by reverse transcriptase/polymerase chain reaction (RT/PCR). Nineteen patients (six MGUS, two primary amyloid (AL), 11 MM) were studied. IL-6 mRNA expression was detectable in the sorted CD38 ؉ /CD45 ؊ plasma cell populations from 0/6 MGUS, 0/2 AL and 5/11 MM patients. All five MM patients with autocrine IL-6 expression demonstrated an elevated plasma cell labeling index. IL-1␤ mRNA was detectable in the sorted CD38 ؉ /CD45 ؊ plasma cell populations from 1/6 MGUS, 0/2 AL and 10/11 MM patients. In situ hybridization (ISH) confirmed that the IL-1␤ producing cells were plasma cells. In conclusion, autocrine production of IL-6 parallels a high labeling index and aberrant expression of IL-1␤ correlates with the diagnosis of MM. Follow-up of IL-1␤-positive MGUS patients will determine whether aberrant expression of IL-1␤ will predict those MGUS patients that will eventually progress to MM.

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“…The action of Kaposi’s sarcoma-associated herpesvirus (KSHV) in the onset of MM has been described [103]. Moreover, Epstein–Barr virus, human immunodeficiency virus-1, and respiratory syncytial virus have been demonstrated to upregulate IL-1 expression either directly by acting with genomic sequences or indirectly by modifying concentrations of transcription factors implicated in IL-1b expression [104,105,106].…”

Section: Introductionmentioning

confidence: 99%

Lymphocyte Subsets and Inflammatory Cytokines of Monoclonal Gammopathy of Undetermined Significance and Multiple Myeloma

Allegra

Innao

Pugliese

et al. 2019

IJMS

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Almost all multiple myeloma (MM) cases have been demonstrated to be linked to earlier monoclonal gammopathy of undetermined significance (MGUS). Nevertheless, there are no identified characteristics in the diagnosis of MGUS that have been helpful in differentiating subjects whose cancer may progress to a malignant situation. Regarding malignancy, the role of lymphocyte subsets and cytokines at the beginning of neoplastic diseases is now incontestable. In this review, we have concentrated our attention on the equilibrium between the diverse lymphocyte subsets and the cytokine system and summarized the current state of knowledge, providing an overview of the condition of the entire system in MGUS and MM. In an age where the therapy of neoplastic monoclonal gammopathies largely relies on drugs capable of acting on the immune system (immunomodulants, immunological checkpoint inhibitors, CAR-T), detailed knowledge of the the differences existing in benign and neoplastic forms of gammopathy is the main foundation for the adequate and optimal use of new drugs.

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Induction of interleukin-1 and glucocorticoid hormones by HIV promotes viral replication and links human chromosome 2 to AIDS pathogenesis: genetic mechanisms and therapeutic implications

Cited by 11 publications

References 47 publications

Involvement of Alarmins in the Pathogenesis and Progression of Multiple Myeloma

Involvement of Alarmins in the Pathogenesis and Progression of Multiple Myeloma

Contrast in cytokine expression between patients with monoclonal gammopathy of undetermined significance or multiple myeloma

Lymphocyte Subsets and Inflammatory Cytokines of Monoclonal Gammopathy of Undetermined Significance and Multiple Myeloma

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