Mannosylerythritol lipids: antimicrobial and biomedical properties

Coelho, Ana Letícia Silva; Feuser, Paulo Emílio; Carciofi, Bruno Augusto Mattar; Andrade, Cristiano José de

doi:10.1007/s00253-020-10354-z

Cited by 73 publications

(53 citation statements)

References 91 publications

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“…There are numerous reports on the anti-tumour activity of MELs against various cancer types. In some, the successful treatment was related to the MEL-containing liposomes as summarised by Silva Coelho et al [ 183 ]. The anticancer effect of MEL-A and MEL-B on human leukaemia HL-60 cell lines was reported by Isoda et al [ 184 ] The surfactants were also found to inhibit the insulin-dependent proliferation of human myelogenous leukaemia cell line K562 through the inhibition of the tyrosine phosphorylation [ 185 , 186 ].…”

Section: Anti-cancer Propertiesmentioning

confidence: 99%

Surface Active Agents and Their Health-Promoting Properties: Molecules of Multifunctional Significance

et al. 2020

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Surface active agents (SAAs) are molecules with the capacity to adsorb to solid surfaces and/or fluid interfaces, a property that allows them to act as multifunctional ingredients (e.g., wetting and dispersion agents, emulsifiers, foaming and anti-foaming agents, lubricants, etc.) in a widerange of the consumer products of various industrial sectors (e.g., pharmaceuticals, cosmetics, personal care, detergents, food, etc.). Given their widespread utilization, there is a continuously growing interest to explore their role in consumer products (relevant to promoting human health) and how such information can be utilized in order to synthesize better chemical derivatives. In this review article, weaimed to provide updated information on synthetic and biological (biosurfactants) SAAs and their health-promoting properties (e.g., anti-microbial, anti-oxidant, anti-viral, anti-inflammatory, anti-cancer and anti-aging) in an attempt to better define some of the underlying mechanism(s) by which they exert such properties.

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Section: Anti-cancer Propertiesmentioning

confidence: 99%

Surface Active Agents and Their Health-Promoting Properties: Molecules of Multifunctional Significance

et al. 2020

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“…They are used in detergent and cleaning solutions and display a very wide range of applications such as food industry, soil and water remediation, microbial enhanced oil recovery, biomedical science, cosmetic industry, nanotechnology and agriculture (Naughton et al, 2019;Singh et al, 2019). They have been studied since decades in biomedical sciences, especially for their antimicrobial properties and as modulators of human innate immunity [for extensive reviews see Singh and Cameotra (2004), Banat et al (2010), Vatsa et al (2010), Naughton et al (2019), Coelho et al (2020), Jahan et al (2020), Sajid et al (2020)]. Some of these microbial biosurfactants exhibit antimicrobial properties that are effective against a large panel of plant pathogens (Mnif and Ghribi, 2016;Penha et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Biosurfactants in Plant Protection Against Diseases: Rhamnolipids and Lipopeptides Case Study

Crouzet

Arias

Dhondt‐Cordelier

et al. 2020

Front. Bioeng. Biotechnol.

117

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Biosurfactants are amphiphilic surface-active molecules that are produced by a variety of microorganisms including fungi and bacteria. Pseudomonas, Burkholderia, and Bacillus species are known to secrete rhamnolipids and lipopeptides that are used in a wide range of industrial applications. Recently, these compounds have been studied in a context of plant-microbe interactions. This mini-review describes the direct antimicrobial activities of these compounds against plant pathogens. We also provide the current knowledge on how rhamnolipids and lipopeptides stimulate the plant immune system leading to plant resistance to phytopathogens. Given their low toxicity, high biodegradability and ecological acceptance, we discuss the possible role of these biosurfactants as alternative strategies to reduce or even replace pesticide use in agriculture.

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“…Mannosylerythritol lipids (MELs) are a class of compounds with amphiphilic properties, classified as a biosurfactant [ 15 ]. Extracellular glycolipid MELs produced by Candida antarctica induced apoptosis, growth arrest, and the differentiation of mouse malignant melanoma B16 cells [ 36 ].…”

Section: Effect Of Bs On the Immune Systemmentioning

confidence: 99%

“…BS have been exploited for applications in gene transfection, vaccine delivery, immunomodulation, cancer therapy, etc. [ 4 , 10 , 11 , 12 , 13 , 14 , 15 ]. BS have been used as immunostimulants in fish culture and have been explored to improve the defense mechanisms of fish against various diseases.…”

Section: Introductionmentioning

confidence: 99%

Immunomodulatory Role of Microbial Surfactants, with Special Emphasis on Fish

Giri

Kim

et al. 2020

IJMS

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Microbial surfactants (biosurfactants) are a broad category of surface-active biomolecules with multifunctional properties. They self-assemble in aqueous solutions and are adsorbed on various interfaces, causing a decrease in surface tension, as well as interfacial tension, solubilization of hydrophobic compounds, and low critical micellization concentrations. Microbial biosurfactants have been investigated and applied in several fields, including bioremediation, biodegradation, food industry, and cosmetics. Biosurfactants also exhibit anti-microbial, anti-biofilm, anti-cancer, anti-inflammatory, wound healing, and immunomodulatory activities. Recently, it has been reported that biosurfactants can increase the immune responses and disease resistance of fish. Among various microbial surfactants, lipopeptides, glycolipids, and phospholipids are predominantly investigated. This review presents the various immunological activities of biosurfactants, mainly glycolipids and lipopeptides. The applications of biosurfactants in aquaculture, as well as their immunomodulatory activities, that make them novel therapeutic candidates have been also discussed in this review.

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Mannosylerythritol lipids: antimicrobial and biomedical properties

Cited by 73 publications

References 91 publications

Surface Active Agents and Their Health-Promoting Properties: Molecules of Multifunctional Significance

Surface Active Agents and Their Health-Promoting Properties: Molecules of Multifunctional Significance

Biosurfactants in Plant Protection Against Diseases: Rhamnolipids and Lipopeptides Case Study

Immunomodulatory Role of Microbial Surfactants, with Special Emphasis on Fish

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