Immunomodulatory Role of Microbial Surfactants, with Special Emphasis on Fish

Giri, Sib Sankar; Kim, Hyoun Joong; Kim, Sang Guen; Kim, Sang Wha; Kwon, Jun-Hun; Lee, Sung Bin; Park, Taesung

doi:10.3390/ijms21197004

Cited by 11 publications

(4 citation statements)

References 97 publications

(129 reference statements)

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“…To date, trehalolipids have been poorly investigated as natural compounds for pharmaceutical applications [59]. Herein, we have demonstrated that the enriched fraction of succinoyl trehalolipids exerted high antiproliferative activity on a prostate cancer cell line (PC3) at 100 µg/mL while being significantly less cytotoxic to the normal counterpart (PNT2) (Figure 3).…”

Section: Discussionmentioning

confidence: 87%

Combining OSMAC Approach and Untargeted Metabolomics for the Identification of New Glycolipids with Potent Antiviral Activity Produced by a Marine Rhodococcus

Esposito

Giugliano

Sala

et al. 2021

IJMS

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Natural products of microbial origin have inspired most of the commercial pharmaceuticals, especially those from Actinobacteria. However, the redundancy of molecules in the discovery process represents a serious issue. The untargeted approach, One Strain Many Compounds (OSMAC), is one of the most promising strategies to induce the expression of silent genes, especially when combined with genome mining and advanced metabolomics analysis. In this work, the whole genome of the marine isolate Rhodococcus sp. I2R was sequenced and analyzed by antiSMASH for the identification of biosynthetic gene clusters. The strain was cultivated in 22 different growth media and the generated extracts were subjected to metabolomic analysis and functional screening. Notably, only a single growth condition induced the production of unique compounds, which were partially purified and structurally characterized by liquid chromatography high-resolution tandem mass spectrometry (LC-HRMS/MS). This strategy led to identifying a bioactive fraction containing >30 new glycolipids holding unusual functional groups. The active fraction showed a potent antiviral effect against enveloped viruses, such as herpes simplex virus and human coronaviruses, and high antiproliferative activity in PC3 prostate cancer cell line. The identified compounds belong to the biosurfactants class, amphiphilic molecules, which play a crucial role in the biotech and biomedical industry.

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Section: Discussionmentioning

confidence: 87%

Combining OSMAC Approach and Untargeted Metabolomics for the Identification of New Glycolipids with Potent Antiviral Activity Produced by a Marine Rhodococcus

Esposito

Giugliano

Sala

et al. 2021

IJMS

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“…Interestingly, BS molecules modulate immune responses by affecting the cellular and humoral arms of the immune system [ 187 , 188 , 189 ]. The immunomodulatory activity of many BSs is primarily exploited by the micro-organism to establish host infection.…”

Section: Immuno-modulatory Activity Of Bssmentioning

confidence: 99%

“…Finally, accumulating studies have demonstrated that BSs enhance immune activation and disease resistance in fish, indicating the potential application of BSs in veterinary sciences [ 188 ].…”

Section: Immuno-modulatory Activity Of Bssmentioning

confidence: 99%

Recent Advances in Biomedical, Therapeutic and Pharmaceutical Applications of Microbial Surfactants

et al. 2021

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The spread of antimicrobial-resistant pathogens typically existing in biofilm formation and the recent COVID-19 pandemic, although unrelated phenomena, have demonstrated the urgent need for methods to combat such increasing threats. New avenues of research for natural molecules with desirable properties to alleviate this situation have, therefore, been expanding. Biosurfactants comprise a group of unique and varied amphiphilic molecules of microbial origin capable of interacting with lipidic membranes/components of microorganisms and altering their physicochemical properties. These features have encouraged closer investigations of these microbial metabolites as new pharmaceutics with potential applications in clinical, hygiene and therapeutic fields. Mounting evidence has indicated that biosurfactants have antimicrobial, antibiofilm, antiviral, immunomodulatory and antiproliferative activities that are exploitable in new anticancer treatments and wound healing applications. Some biosurfactants have already been approved for use in clinical, food and environmental fields, while others are currently under investigation and development as antimicrobials or adjuvants to antibiotics for microbial suppression and biofilm eradication strategies. Moreover, due to the COVID-19 pandemic, biosurfactants are now being explored as an alternative to current products or procedures for effective cleaning and handwash formulations, antiviral plastic and fabric surface coating agents for shields and masks. In addition, biosurfactants have shown promise as drug delivery systems and in the medicinal relief of symptoms associated with SARS-CoV-2 acute respiratory distress syndrome.

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“…Currently, BS are an essential component in various industrial applications (Giri et al 2020 ). BS have been investigated to strengthen marine fish defence systems against different infections and have been employed as immunostimulants in marine fish production (Giri et al 2020 ).…”

Section: Current Solutionsmentioning

confidence: 99%

Bacterial diseases in marine fish species: current trends and future prospects in disease management

Hegde,

Kabra,

Basawa

et al. 2023

World J Microbiol Biotechnol

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The fisheries sub-sector of aquaculture—i.e., the pisciculture industry, contributes significantly to a country’s economy, employing a sizable proportion of the population. It also makes important contributions to household food security because the current demand for animal protein cannot be fulfilled by harvesting wild fish from riverines, lakes, dams, and oceans. For good pond management techniques and sustaining fish health, the fisherfolk, and the industry require well-established regulatory structures, efficient disease management strategies, and other extended services. In rearing marine fish, infections resulting from disease outbreaks are a weighty concern because they can cause considerable economic loss due to morbidity and mortality. Consequently, to find effective solutions for the prevention and control of the major diseases limiting fish production in aquaculture, multidisciplinary studies on the traits of potential fish pathogens, the biology of the fish as hosts, and an adequate understanding of the global environmental factors are fundamental. This review highlights the various bacterial diseases and their causative pathogens prevalent in the pisciculture industry and the current solutions while emphasising marine fish species. Given that preexisting methods are known to have several disadvantages, other sustainable alternatives like antimicrobial peptides, synthetic peptides, probiotics, and medicinal treatments have emerged to be an enormous potential solution to these challenges. Graphical abstract

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Immunomodulatory Role of Microbial Surfactants, with Special Emphasis on Fish

Cited by 11 publications

References 97 publications

Combining OSMAC Approach and Untargeted Metabolomics for the Identification of New Glycolipids with Potent Antiviral Activity Produced by a Marine Rhodococcus

Combining OSMAC Approach and Untargeted Metabolomics for the Identification of New Glycolipids with Potent Antiviral Activity Produced by a Marine Rhodococcus

Recent Advances in Biomedical, Therapeutic and Pharmaceutical Applications of Microbial Surfactants

Bacterial diseases in marine fish species: current trends and future prospects in disease management

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