Mannose-Derived Carbon Dots Amplify Microwave Ablation-Induced Antitumor Immune Responses by Capturing and Transferring “Danger Signals” to Dendritic Cells

Zhou, Qunfang; Gong, Ningqiang; Zhang, Dongyun; Li, Jing; Han, Xue; Dou, Jianping; Huang, Jinhua; Zhu, Kangshun; Liang, Ping; Liang, Xing‐Jie; Yu, Jie

doi:10.1021/acsnano.0c09120

Cited by 55 publications

(47 citation statements)

References 44 publications

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“…It is well known that electromagnetic waves are widely used in clinical medicine, such as in microwave ablation of tumors and microwave physiotherapy [23][24][25][26]. At the same time, many studies have focused on the biological effects around different frequency bands [27][28][29].…”

Section: Discussionmentioning

confidence: 99%

Beneficial Effects of 1500 MHz Microwave on Old 5×FAD Mice

Sun

Zhu

et al. 2022

Preprint

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Background: Treatment of Alzheimer’s disease is still a medical challenge now. Some researchers have tried to use electromagnetic therapy to treat Alzheimer’s disease, but there are no clear conclusions. 1500 MHz microwave was used to expose young and old 5×FAD mice here to explore the beneficial effect of microwave on Alzheimer’s disease.Methods: Young and old 5×FAD mice were exposed to 1500 MHz microwave at SARs of 2 or 4 W/kg for 5-months (2 h/day, 5 days/week). The cognitive function and emotional behavior were detected by Morris Water Maze, Y-Maze, Open Field Test and Elevated Plus Maze respectively. Amyloid β peptides, BACE1 expression, and inflammatory cytokines interleukin were detected by ELISA and qPCR. Amyloid β peptides and Iba1 in hippocampus of old FAD mice were further detected with immunohistochemistry.Results: Microwave treatment obviously improved the learning and memory in old AD mice after 5 months of exposure, which was confirmed by the significant decreased Aβ42 peptides and downregulated BACE1 expression in hippocampus. 1500 MHz microwave exposure caused anxiety-like behavior in young and old AD mice at a SAR of 2 W/kg and 4 W/kg respectively. IL-6 mRNA levels were significantly decreased while IL-4 and IL-10 were significantly increased in old AD mice after exposure at a SAR of 2 W/kg. At the same time, the amount of microglia along with Aβ deposition were significantly decreased in hippocampus. The weight loss of aged AD mice slowed down and no obvious increase of anal temperature was found during exposure.Conclusions: 1500 MHz microwave exposure can significantly improve the symptoms of AD in aged mice at a SAR of 2 W/kg with the regulations of inflammatory reaction in hippocampus, which may provide an effective clinical choice for treatment of elderly patients with AD.

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Section: Discussionmentioning

confidence: 99%

Beneficial Effects of 1500 MHz Microwave on Old 5×FAD Mice

Sun

Zhu

et al. 2022

Preprint

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“…Nanoparticle-based immunotherapy delivery systems have been explored for reducing the side effects of immunotherapeutic drugs as well as modulating the immunosuppressive tumor microenvironment for a robust activation of the immune system. Recent findings of “sticky” nanoparticles with many functional groups like carboxyl, hydroxyl and amine that capture tumor-associated antigens and DAMPs from ablated tumor cells show an efficient method of capture-and-delivery of the tumor lysates to antigen-presenting cells such as dendritic cells, which in turn travel to lymph nodes to activate T cells 225 - 227 . Imaging, such as MRI, may be useful for validating that the nanoparticles have correctly migrated into the lymph node for the crosstalk between innate and adaptive immunity.…”

Section: Nanomaterials In Cryoablation: a New Opportunitymentioning

confidence: 99%

Recent progress in cryoablation cancer therapy and nanoparticles mediated cryoablation

Kwak¹,

B²,

Lewandowski³

et al. 2022

Theranostics

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With rapid advances in modern imaging, minimally invasive ablative procedures have emerged as popular alternatives to surgical removal of tumors. Tumor ablation modalities currently offered in clinical practice include microwave ablation, radiofrequency ablation, cryoablation, high-intensity focused ultrasound, and irreversible electroporation. Cryoablation, a non-heat-based method of ablation, is increasingly being used for treating various solid tumors. Accumulated comparative data of cryoablation versus heat-based ablation techniques (e.g., radiofrequency and microwave ablation) shows superior tumor response and quicker recovery time. Evolving research has demonstrated that nanocarriers may serves as excellent catalysts for the cryoablation therapy, imaging guidance, and the co-delivery of therapeutics for minimally invasive, precise, and complete treatment of cancer with immune modulation. This review article focuses on the current status of cryoablation in clinical practice, considers opportunities for enhancing therapeutic outcomes from cryoablation, and discusses new research in the field, including theranostic nanoparticles-mediated cryotherapy and combinational cryo-based immunotherapies.

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“…Some CQDs can capture TAAs, while some carbohydrate modifiers can target dendritic cells (DCs), and mannose-based CQDs (Man-CDs) combine the two. 190 Man-CDSs can deliver captured TAAs to DCs, activate the immune system and amplify MWA, thus skillfully combining drug delivery with immunotherapy. Silver nanoparticles are natural nanodrugs that kill tumour cells.…”

Section: Dovepressmentioning

confidence: 99%

Recent Advances in Functional Carbon Quantum Dots for Antitumour

Cai¹,

Xiao²,

Liu³

et al. 2021

IJN

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Carbon quantum dots (CQDs) are an emerging class of quasi-zero-dimensional photoluminescent nanomaterials with particle sizes less than 10 nm. Owing to their favourable water dispersion, strong chemical inertia, stable optical performance, and good biocompatibility, CQDs have become prominent in biomedical fields. CQDs can be fabricated by "top-down" and "bottom-up" methods, both of which involve oxidation, carbonization, pyrolysis and polymerization. The functions of CQDs include biological imaging, biosensing, drug delivery, gene carrying, antimicrobial performance, photothermal ablation and so on, which enable them to be utilized in antitumour applications. The purpose of this review is to summarize the research progress of CQDs in antitumour applications from preparation and characterization to application prospects. Furthermore, the challenges and opportunities of CQDs are discussed along with future perspectives for precise individual therapy of tumours.

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Mannose-Derived Carbon Dots Amplify Microwave Ablation-Induced Antitumor Immune Responses by Capturing and Transferring “Danger Signals” to Dendritic Cells

Cited by 55 publications

References 44 publications

Beneficial Effects of 1500 MHz Microwave on Old 5×FAD Mice

Beneficial Effects of 1500 MHz Microwave on Old 5×FAD Mice

Recent progress in cryoablation cancer therapy and nanoparticles mediated cryoablation

Recent Advances in Functional Carbon Quantum Dots for Antitumour

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