Mannose-binding lectin gene polymorphism and its impact on human immunodeficiency virus 1 infection

Vallinoto, Antônio Carlos Rosário; Menezes-Costa, Marcos Rogério; Alves, Anna; Machado, Luiz Fernando Almeida; Azevedo, Vânia Nakauth; Souza, Lia Lobato Batista de; Ishak, Marluísa de Oliveira Guimarães; Ishak, Ricardo

doi:10.1016/j.molimm.2005.09.001

Cited by 31 publications

(29 citation statements)

References 25 publications

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“…The presence of mutations in exon 1 of the MBL gene has been associated with the occurrence of immunodeficiency and chronic infection diseases (Kilpatrick 2002, Turner 2003. In our study, the variant MBL*B was clearly associated with higher plasma viral load levels (Vallinoto et al 2006).…”

Section: Discussionsupporting

confidence: 55%

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Characterization of polymorphisms in the mannose-binding lectin gene promoter among human immunodeficiency virus 1 infected subjects

Vallinoto

Muto

Alves

et al. 2008

Mem. Inst. Oswaldo Cruz

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Section: Discussionsupporting

confidence: 55%

“…In Belém, a significant increase of the MBL*B variant among HIV-1-infected subjects was observed (Vallinoto et al 2006). Although the genotype B/B was six times more frequent, neither allele nor genotype differences were significant.…”

Section: Discussionmentioning

confidence: 89%

Characterization of polymorphisms in the mannose-binding lectin gene promoter among human immunodeficiency virus 1 infected subjects

Vallinoto

Muto

Alves

et al. 2008

Mem. Inst. Oswaldo Cruz

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“…MBL gene polymorphism and low plasma concentrations of MBL may affect HIV-1 infection by reducing activation of the complement system, resulting in an increase in the plasma viral load 7,10 . However, the results presented here do not support this conclusion, given the absence of any relation between the presence of the MBL*O allele and viral load, despite significant differences in MBL plasma concentrations according to genotype.…”

Section: Discussionmentioning

confidence: 99%

“…Three mutations of the wild allele MBL*A have been identified in the structural region of the molecule (codons 52, 54 and 57) with three allelic variants named MBL*D, MBL*B and MBL*C, respectively 4 . These variants have been associated with MBL serum deficiency and, consequently, variations in the susceptibility or resistance to infection in carriers by a number of pathogens [5][6][7][8] .…”

Section: Introductionmentioning

confidence: 99%

Characterization of mannose-binding lectin plasma levels and genetic polymorphisms in HIV-1-infected individuals

Vallinoto

Freitas

Guirelli

et al. 2011

Rev. Soc. Bras. Med. Trop.

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Introduction: The present study investigated the association between mannose-binding lectin (MBL) gene polymorphism and serum levels with infection by HIV-1. Methods: Blood samples (5mL) were collected from 97 HIV-1-infected individuals resident in Belém, State of Pará, Brazil, who attended the Special Outpatient Unit for Infections and Parasitic Diseases (URE-DIPE). CD4 + T-lymphocyte count and plasma viral load were quantified. A 349bp fragment of exon 1 of the MBL was amplified via PCR, using genomic DNA extracted from controls and HIV-1-infected individuals, following established protocols. MBL plasma levels of the patients were quantified using an enzyme immunoassay kit. Results: Two alleles were observed: MBL*O, with a frequency of 26.3% in HIV-1-infected individuals; and the wild allele MBL*A (73.7%). Similar frequencies were observed in the control group (p > 0.05). Genotype frequencies were distributed according to the Hardy-Weinberg equilibrium in both groups. Mean MBL plasma levels varied by genotype, with statistically significant differences between the AA and AO (p < 0.0001), and AA and OO (p < 0.001) genotypes, but not AO and OO (p = 0.17). Additionally, CD4+ T-lymphocytes and plasma viral load levels did not differ significantly by genotype (p > 0.05). Conclusions: The results of this study do not support the hypothesis that MBL gene polymorphism or low plasma MBL concentrations might have a direct influence on HIV-1 infection, although a broader study involving a large number of patients is needed.

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“…The occurrence of these variants have been associated with MBL serum deficiency and consequently to susceptibility/resistance to infection by various pathogens, including HIV-1 (Drogari-Apiranthitou et al Garred et al, 1997;Prohászka et al, 1997;Luty et al, 1998;Hibberd et al, 1999;Peterslund et al, 2001;Klabunde et al, 2002;Roy et al, 2002;Song et al, 2003). It was investigated the association between MBL gene polymorphism and the susceptibility to HIV-1 infection (Vallinoto et al, 2006). The study of 145 HIV-1-infected subjects and 99 healthy controls showed the presence of alleles MBL*A, MBL*B and MBL*D, whose frequencies were 69%, 22% and 09% among patients and 71%, 13% and 16% among healthy controls, respectively.…”

Section: Genetic Background Of Hiv-1 Infected Subjectsmentioning

confidence: 99%

Molecular Epidemiology of HIV-1 Infection in the Amazon Region

Vallinoto¹,

Machado²,

Ishak³

et al. 2011

HIV and AIDS - Updates on Biology, Immunology, Epidemiology and Treatment Strategies

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Mannose-binding lectin gene polymorphism and its impact on human immunodeficiency virus 1 infection

Cited by 31 publications

References 25 publications

Characterization of polymorphisms in the mannose-binding lectin gene promoter among human immunodeficiency virus 1 infected subjects

Characterization of polymorphisms in the mannose-binding lectin gene promoter among human immunodeficiency virus 1 infected subjects

Characterization of mannose-binding lectin plasma levels and genetic polymorphisms in HIV-1-infected individuals

Molecular Epidemiology of HIV-1 Infection in the Amazon Region

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