Manipulation of micro-particles by flexible polymer-based optically-induced dielectrophoretic devices

Lin, Shu-Ju; Hung, Shih-Hsun; Jeng, Jun-Yuan; Guo, Tzung‐Fang; Lee, Gwo‐Bin

doi:10.1364/oe.20.000583

Cited by 18 publications

(11 citation statements)

References 25 publications

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“…Such optically-induced systems are constructed by illuminating light patterns onto photoconductive materials while an alternating-current (AC) electrical field is applied. Hydrogen-rich, amorphous silicon (a-Si: H) and photoconductive polymers 22 23 are common materials used for this application. As light patterns are projected onto the photoconductive film, the conductivity of the illuminated region can be raised by several orders of magnitude, depending upon the illumination intensity, light wavelength, and photoconductivity of the material.…”

mentioning

confidence: 99%

Optically-Induced Cell Fusion on Cell Pairing Microstructures

Yang

Wang

Lee

2016

Sci Rep

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Cell fusion is a critical operation for numerous biomedical applications including cell reprogramming, hybridoma formation, cancer immunotherapy, and tissue regeneration. However, unstable cell contact and random cell pairings have limited efficiency and yields when utilizing traditional methods. Furthermore, it is challenging to selectively perform cell fusion within a group of cells. This study reports a new approach called optically-induced cell fusion (OICF), which integrates cell-pairing microstructures with an optically-induced, localized electrical field. By projecting light patterns onto a photoconductive film (hydrogen-rich, amorphous silicon) coated on an indium-tin-oxide (ITO) glass while an alternating current electrical field was applied between two such ITO glass slides, “virtual” electrodes could be generated that could selectively fuse pairing cells. At 10 kHz, a 57% cell paring rate and an 87% fusion efficiency were successfully achieved at a driving voltage of 20 Vpp, suggesting that this new technology could be promising for selective cell fusion within a group of cells.

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confidence: 99%

Optically-Induced Cell Fusion on Cell Pairing Microstructures

Yang

Wang

Lee

2016

Sci Rep

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“…This effect then differs from previously reported studies of dielectric particles in OET devices. The metallic microspheres can modify the electric field distribution in the OET device significantly, which is very different from dielectric microspheres such as PMMA and glass microspheres2425. Since the metallic microsphere can not be well represented by a single dipole and the gradient of electric field squared varies significantly across the metallic microsphere, the traditional way of calculating the DEP force based on the dipole moment and average gradient of the electric field squared is not applicable.…”

Section: Simulation and Discussionmentioning

confidence: 99%

Manipulating and assembling metallic beads with Optoelectronic Tweezers

Zhang

Juvert

Cooper

et al. 2016

Sci Rep

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Optoelectronic tweezers (OET) or light-patterned dielectrophoresis (DEP) has been developed as a micromanipulation technology for controlling micro- and nano-particles with applications such as cell sorting and studying cell communications. Additionally, the capability of moving small objects accurately and assembling them into arbitrary 2D patterns also makes OET an attractive technology for microfabrication applications. In this work, we demonstrated the use of OET to manipulate conductive silver-coated Poly(methyl methacrylate) (PMMA) microspheres (50 μm diameter) into tailored patterns. It was found that the microspheres could be moved at a max velocity of 3200 μm/s, corresponding to 4.2 nano-newton (10−9 N) DEP force, and also could be positioned with high accuracy via this DEP force. The underlying mechanism for this strong DEP force is shown by our simulations to be caused by a significant increase of the electric field close to the particles, due to the interaction between the field and the silver shells coating the microspheres. The associated increase in electrical gradient causes DEP forces that are much stronger than any previously reported for an OET device, which facilitates manipulation of the metallic microspheres efficiently without compromise in positioning accuracy and is important for applications on electronic component assembling and circuit construction.

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“…Compared to a-Si:H based OEK chips, OEK chips based on this material are much easier to fabricate, except that the fabrication process of the latter requires preventing the polymer film from being collapsed by either water or oxygen. OEK chips based on this material can bend up and down freely to produce concave or convex curvatures, which leads to significantly higher efficiency in separating and concentrating differently sized polystyrene beads [49]. Another kind of OEK chip was devised based on TiOPc, an organic photosensitive material.…”

Section: Optoelectrokinetics (Oek) Chips and Their Working Principlesmentioning

confidence: 99%

A Review on Optoelectrokinetics-Based Manipulation and Fabrication of Micro/Nanomaterials

et al. 2020

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Optoelectrokinetics (OEK), a fusion of optics, electrokinetics, and microfluidics, has been demonstrated to offer a series of extraordinary advantages in the manipulation and fabrication of micro/nanomaterials, such as requiring no mask, programmability, flexibility, and rapidness. In this paper, we summarize a variety of differently structured OEK chips, followed by a discussion on how they are fabricated and the ways in which they work. We also review how three differently sized polystyrene beads can be separated simultaneously, how a variety of nanoparticles can be assembled, and how micro/nanomaterials can be fabricated into functional devices. Another focus of our paper is on mask-free fabrication and assembly of hydrogel-based micro/nanostructures and its possible applications in biological fields. We provide a summary of the current challenges facing the OEK technique and its future prospects at the end of this paper.

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Manipulation of micro-particles by flexible polymer-based optically-induced dielectrophoretic devices

Cited by 18 publications

References 25 publications

Optically-Induced Cell Fusion on Cell Pairing Microstructures

Optically-Induced Cell Fusion on Cell Pairing Microstructures

Manipulating and assembling metallic beads with Optoelectronic Tweezers

A Review on Optoelectrokinetics-Based Manipulation and Fabrication of Micro/Nanomaterials

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