Manipulation of magnetic particles by patterned arrays of magnetic spin-valve traps

Mirowski, Elizabeth; Moreland, John; Russek, Stephen E.; Donahue, Michael J.; Hsieh, Kuangwen

doi:10.1016/j.jmmm.2006.11.202

Cited by 23 publications

(20 citation statements)

References 20 publications

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“…Superparamagnetic beads are widely used within bioscience to separate, organize and manipulate biomolecules and cells, [1][2][3][4][5][6] and have promising clinical applications as they can be used as MRI contrast agents and in magnetic hyperthermia for the treatment of cancer. 7,8 Typically, they consist of iron oxide (Fe 2 O 3 or Fe 3 O 4 ) nanoparticles embedded in a polymer matrix, which may have an outer coating functionalized for a particular biological application.…”

mentioning

confidence: 99%

“…9 The force due to an externally applied magnetic field on a superparamagnetic bead below saturation conditions is proportional to both the magnetic field strength and the field gradient. This has recently been exploited by devices that manipulate beads using stray fields from localized field sources such as closure domains of patterned elements 4,10,11 or domain walls in nanowires. 5,6,12,13 If the beads are attached to cells, the use of nanostructures enables the alignment or pattering of cells, 6 providing a fundamental control over cellular organization, which could generate future tissue engineering applications.…”

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confidence: 99%

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The effect of trapping superparamagnetic beads on domain wall motion

Bryan

Dean

Schrefl

et al. 2010

Applied Physics Letters

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Domain walls may act as localized field sources to trap and move superparamagnetic beads for manipulating biological cells and DNA. The interaction between beads of various diameters and a wall is investigated using a combination of micromagnetic and analytical models. Domain walls can transport beads under applied magnetic fields, but the mutual attraction between the bead and wall causes drag forces affecting the bead to couple into the wall motion. Therefore, the interaction with the bead causes a fundamental change in the domain wall dynamics, reducing the wall mobility by five orders of magnitude.

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mentioning

confidence: 99%

mentioning

confidence: 99%

The effect of trapping superparamagnetic beads on domain wall motion

Bryan

Dean

Schrefl

et al. 2010

Applied Physics Letters

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“…Superparamagnetic beads and wires are widely used within bioscience to separate, organize and manipulate biomolecules and cells [Tanase 2005, Inglis 2006, Desai 2007, Mirowski 2007, Vieira 2009]. The beads can be incorporated into biological cells without affecting cellular viability [Desai 2007] and are attracted towards magnetic poles [Mirowski 2004, Tanase 2005, Mirowski 2007, Conroy 2008, Vieira 2009.…”

Section: Imentioning

confidence: 99%

“…The beads can be incorporated into biological cells without affecting cellular viability [Desai 2007] and are attracted towards magnetic poles [Mirowski 2004, Tanase 2005, Mirowski 2007, Conroy 2008, Vieira 2009. Lithographed micrometer-scale magnetic structures enable the position of magnetic poles to be controlled, providing a method of influencing the absolute position of the beads on a surface.…”

Section: Imentioning

confidence: 99%

Switchable Cell Trapping Using Superparamagnetic Beads

et al. 2010

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Abstract-Ni81Fe19 microwires are investigated as the basis of a switchable template for positioning magnetically-labeled neural Schwann cells. Magnetic transmission X-ray microscopy and micromagnetic modeling show that magnetic domain walls can be created or removed in zigzagged structures by an applied magnetic field. Schwann cells containing superparamagnetic beads are trapped by the field emanating from the domain walls. The design allows Schwann cells to be organized on a surface to form a connected network and then released from the surface if required. As aligned Schwann cells can guide nerve regeneration, this technique is of value for developing glial-neuronal co-culture models in the future treatment of peripheral nerve injuries.

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“…In general, microfluidic devices are passive systems which utilize fluidic behavior for manipulating biological cells within structures of micrometer dimensions; this is a field of study closely related to chemical cytometry [3]. On the other hand, active micro devices such as current carrying conductors, permanent magnets and electromagnets utilize magnetic forces for the manipulation of biomolecule carriers [4][5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Programmable Magnetic Actuation of Biomolecule Carriers using NiFe Stepping Stones

Lim¹,

Jeong²,

Kim³

et al. 2011

Journal of Magnetics

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We have designed, fabricated and demonstrated a novel micro-system for programmable magnetic actuation using magnetic elliptical pathways on Si substrates. Lithographically patterned soft NiFe ellipses are arranged sequentially perpendicular to each other as stepping stones for the transport of magnetic beads. We have measured the magnetization curve of the ellipsoid (9 µm × 4 µm × 0.1 µm) elements with respect to the long and short axes of the ellipse. We found that the magnetization in the long axis direction is larger than that in the short axis direction for an applied field of ≤ 1,000 Oe, causing a force on carriers that causes them to move from one element to another. We have successfully demonstrated a micro-system for the magnetic actuation of biomolecule carriers of superparamagnetic beads (Dynabead ® 2.8 µm) by rotating the external magnetic field. This novel concept of magnetic actuation is useful for future integrated lab-on-a-chip systems for biomolecule manipulation, separation and analysis.

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Manipulation of magnetic particles by patterned arrays of magnetic spin-valve traps

Cited by 23 publications

References 20 publications

The effect of trapping superparamagnetic beads on domain wall motion

The effect of trapping superparamagnetic beads on domain wall motion

Switchable Cell Trapping Using Superparamagnetic Beads

Programmable Magnetic Actuation of Biomolecule Carriers using NiFe Stepping Stones

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