This article presents an exhaustive survey of the literature which has concentrated upon the relationship between social class and mental disease. Studies through the year 1966 are included. For this survey, social class has been operationalized in terms of the following variables: income, occupation, prestige, residential area, or a composite index. Mental disease is operationalized in terms of clinical diagnosis, hospitalization classification, or psychiatric interview. The 6nal section discusses trends in both theory and research over the past sixty-five years. Gy3 DIFFERENCES BETWEEN RURAL AND URBAN AREAS ARLY theoretical statements concerned E with the influence of environment upon were considered t o be mentally ill through one of the following mechanisms of definition: clinical diagnosis, hospitalization classification, or psychiatric interview. We are indebted to Joseph Lopreato, University of Texas, for suggestions on an earlier draft of this paper. agecause of the length of bibliography, all citations in the text of this paper will be referred to by number rather than date (Editor). D. Middle class father's occupational role and attitudes toward children. Amer. J . Orlhopsychiat., 1952, 22, 366-378. 2. Adler, H. M. The relation between psychiatry and the social sciences. Amer. J . Psychial.. 3. Adler, L. M., et al. Failed psychiatric clinic appointments: relationship to social class.