Mangrove rare actinobacteria: taxonomy, natural compound, and discovery of bioactivity

Abstract

Actinobacteria are one of the most important and efficient groups of natural metabolite producers. The genus Streptomyces have been recognized as prolific producers of useful natural compounds as they produced more than half of the naturally-occurring antibiotics isolated to-date and continue as the primary source of new bioactive compounds. Lately, Streptomyces groups isolated from different environments produced the same types of compound, possibly due to frequent genetic exchanges between species. As a result, there is a dramatic increase in demand to look for new compounds which have pharmacological properties from another group of Actinobacteria, known as rare actinobacteria; which is isolated from special environments such as mangrove. Recently, mangrove ecosystem is becoming a hot spot for studies of bioactivities and the discovery of natural products. Many novel compounds discovered from the novel rare actinobacteria have been proven as potential new drugs in medical and pharmaceutical industries such as antibiotics, antimicrobials, antibacterials, anticancer, and antifungals. This review article highlights the latest studies on the discovery of natural compounds from the novel mangrove rare actinobacteria and provides insight on the impact of these findings.

Streptomyces colonosanans sp. nov., A Novel Actinobacterium Isolated from Malaysia Mangrove Soil Exhibiting Antioxidative Activity and Cytotoxic Potential against Human Colon Cancer Cell Lines

“…Particularly, the dominant genus of this phylum which is Streptomyces have a significant contribution to mankind (Azman et al, 2015). The genus Streptomyces is proposed by Waksman and Henrici (1943) and it is a group of Gram positive bacteria comprised ~780 species with validly published names (http://www.bacterio.cict.fr/).…”

Marine Rare Actinobacteria: Isolation, Characterization, and Strategies for Harnessing Bioactive Compounds

“…These marine actinobacteria with potential of producing bioactive compounds have attracted major attention to search for unique compounds with pharmaceutical and biotechnological applications (Bull and Stach, 2007; Subramani and Aalbersberg, 2013; Azman et al, 2015). Recently, there are reports on the discovery of rare actinobacteria from wide range of terrestrial and aquatic locations, including deep seas (Goodfellow et al, 2012).…”

A study on biological activity of marine fungi from different habitats in coastal regions

“…This is a semi open system, due to tides rise and fall, the environment changes frequently, mangrove plants are deciduous, so mangrove habitats contain abundant organic carbon which allows microbes to thrive inalo (Departamento et al 2012; Azman et al 2015). Mangrove sediments are characteristic of strong reduction, low pH, high salinity, nutrient rich, etc., which have rich resources in microbe (Andreote et al 2012).…”