Mangiferin Rich Products from Aphloia theiformis (Vahl) Benn Leaves: Extraction, Fractionation, Phytochemical Characterization, and Antioxidant Properties

Grauzdytė, Dovilė; Pukalskas, Audrius; Kalamouni, Chaker El; Venskutonis, Petras Rimantas

doi:10.3390/molecules25092081

Cited by 5 publications

(2 citation statements)

References 38 publications

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“…This process splits the higher quantities of bioactive compounds from the complex mixtures, which could be applied to separate the target compounds. This is an important step in bio-guided assays of new phytochemical ingredients [ 32 ]. Chua et al [ 33 ] reported that highly polar substances, such as organic acids, polysaccharides, and proteins, might remain in the aqueous phase, while the other less polar compounds, including terpenoids, could be segregated into the organic phase.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Metabolite Profiles of Ginseng Berry Pomace Obtained after Different Pressure Treatments and Their Correlation with the Antioxidant Activity

et al. 2021

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Ginseng berry pomace (GBP) is a byproduct of ginseng berry processing and is rich in numerous bioactive components, including ginsenosides and their derivatives. The application of GBP as a beneficial biomaterial is currently limited. In this study, we aimed to evaluate their potential as a promising source of bioactive compounds using metabolite profiling. The GBP obtained after different ultra-high-pressure (UHP) treatments was analyzed by GC-TOF-MS and UHPLC-LTQ-Orbitrap-MS/MS. In multivariate analyses, we observed a clear demarcation between the control and UHP-treated groups. The results demonstrated that the relative abundance of primary metabolites and a few ginsenosides was higher in the control, whereas UHP treatment contained higher levels of fatty acids and sugars. Furthermore, GBPs were fractionated using different solvents, followed by UHPLC-LTQ-Orbitrap-MS/MS analyses. The heatmap revealed that phenolics (e.g., quercetin, kaempferol) and fewer polar ginsenosides (e.g., F4, Rh2) were abundant in the ethyl acetate fraction, whereas the levels of lignans (e.g., 7-hydroxysecoisolariciresinol, syringaresinol) and fatty acids (e.g., trihydroxy-octadecenoic acid, oxo-dihydroxy-octadecenoic acid) were high in chloroform. Correlation analysis showed that phenolics, less polar ginsenosides, and fatty acids were positively correlated with the antioxidant activity of GBP. Our study highlights GBP as a functional ingredient for the development of high-quality ginseng berry products.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Metabolite Profiles of Ginseng Berry Pomace Obtained after Different Pressure Treatments and Their Correlation with the Antioxidant Activity

et al. 2021

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“…Aquilaria leaf was subjected to mangiferin extraction using ultrahigh-performance liquid chromatography (UHPLC) coupled with electrospray ionization (ESI) tandem mass spectrometry (MS/MS) method [18]. Mangiferin was also extracted from Aphloia theiformis using liquid-liquid extraction followed by UPLC-QTOF-MS [19].…”

Section: Mangiferin: Natural Sources and Extraction Methodsmentioning

confidence: 99%

Renoprotective Effects of Mangiferin: Pharmacological Advances and Future Perspectives

Akter¹,

Moni²,

Faisal

et al. 2022

IJERPH

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Both acute and chronic kidney diseases substantially contribute to the morbidities and mortality of patients worldwide. The existing therapeutics, which are mostly developed from synthetic sources, present some unexpected effects in patients, provoking researchers to explore potential novel alternatives. Natural products that have protective effects against various renal pathologies could be potential drug candidates for kidney diseases. Mangiferin is a natural polyphenol predominantly isolated from Mangifera indica and possesses multiple health benefits against various human ailments, including kidney disease. The main objective of this review is to update the renoprotective potentials of mangiferin with underlying molecular pharmacology and to highlight the recent development of mangiferin-based therapeutics toward kidney problems. Literature published over the past decade suggests that treatment with mangiferin attenuates renal inflammation and oxidative stress, improves interstitial fibrosis and renal dysfunction, and ameliorates structural alteration in the kidney. Therefore, mangiferin could be used as a multi-target therapeutic candidate to treat renal diseases. Although mangiferin-loaded nanoparticles have shown therapeutic promise against various human diseases, there is limited information on the targeted delivery of mangiferin in the kidney. Further research is required to gain insight into the molecular pharmacology of mangiferin targeting kidney diseases and translate the preclinical results into clinical use.

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Pharmacological properties of mangiferin: bioavailability, mechanisms of action and clinical perspectives

Zivković,

Kumar,

Rushendran

et al. 2023

Naunyn-Schmiedeberg's Arch Pharmacol

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Mangiferin Rich Products from Aphloia theiformis (Vahl) Benn Leaves: Extraction, Fractionation, Phytochemical Characterization, and Antioxidant Properties

Cited by 5 publications

References 38 publications

Evaluation of Metabolite Profiles of Ginseng Berry Pomace Obtained after Different Pressure Treatments and Their Correlation with the Antioxidant Activity

Evaluation of Metabolite Profiles of Ginseng Berry Pomace Obtained after Different Pressure Treatments and Their Correlation with the Antioxidant Activity

Renoprotective Effects of Mangiferin: Pharmacological Advances and Future Perspectives

Pharmacological properties of mangiferin: bioavailability, mechanisms of action and clinical perspectives

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