Mangiferin in cancer chemoprevention and treatment: pharmacokinetics and molecular targets

Rajendran, Peramaiyan; Rengarajan, Thamaraiselvan; Nandakumar, Natarajan; Divya, H.; Nishigaki, Ikuo

doi:10.3109/10799893.2014.931431

Cited by 58 publications

(45 citation statements)

References 80 publications

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“…It also inhibited cell cycle progression via ATR-Chk1 DNA damage stress-response pathways, leading to cell cycle-arrest in leukemia cells at the G2/M phase [37]. Mangiferin targets several proinflammatory transcription factors, growth factors, cell-cycle proteins, cytokines, kinases, adhesion molecules, chemokines, and inflammatory enzymes by inhibiting the initiation, promotion, and metastasis stages of cancer [38]. Estrogen receptor alpha (ERα) and beta (ERβ) are two regulators of gene transcription responsible for breast cancer.…”

Section: Health Perspectivesmentioning

confidence: 99%

Mangiferin: a natural miracle bioactive compound against lifestyle related disorders

et al. 2017

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The current review article is an attempt to explain the therapeutic potential of mangiferin, a bioactive compound of the mango, against lifestyle-related disorders. Mangiferin (2-β-D-glucopyranosyl-1,3,6,7-tetrahydroxy-9H-xanthen-9-one) can be isolated from higher plants as well as the mango fruit and their byproducts (i.e. peel, seed, and kernel). It possesses several health endorsing properties such as antioxidant, antimicrobial, antidiabetic, antiallergic, anticancer, hypocholesterolemic, and immunomodulatory. It suppresses the activation of peroxisome proliferator activated receptor isoforms by changing the transcription process. Mangiferin protects against different human cancers, including lung, colon, breast, and neuronal cancers, through the suppression of tumor necrosis factor α expression, inducible nitric oxide synthase potential, and proliferation and induction of apoptosis. It also protects against neural and breast cancers by suppressing the expression of matrix metalloproteinase (MMP)-9 and MMP-7 and inhibiting enzymatic activity, metastatic potential, and activation of the β-catenin pathway. It has the capacity to block lipid peroxidation, in order to provide a shielding effect against physiological threats. Additionally, mangiferin enhances the capacity of the monocyte-macrophage system and possesses antibacterial activity against gram-positive and gram-negative bacteria. This review summarizes the literature pertaining to mangiferin and its associated health claims.

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Section: Health Perspectivesmentioning

confidence: 99%

Mangiferin: a natural miracle bioactive compound against lifestyle related disorders

et al. 2017

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“…Mgf, serving as a potent polyphenol, has been shown to affect several biological processes, like inhibition of NF-kB and other transcription factors, reactive oxygen species (ROS), angiogenesis, and apoptosis including mitochondrial bioenergetics [29]. It is reported that the anticancer activity is achieved by cell cycle arrest and direct apoptosis, while its chemoprotective action could be attributed due to its antioxidant and anti-inflammatory activities [30]. These targets enable the chemopreventive actions of Mgf by inhibiting the initiation, promotion and metastasis of cancer.…”

Section: Targets For Antioxidant Properties Of Mgf: Molecular Levelmentioning

confidence: 99%

Mangiferin: a Promising Anticancer Bioactive

et al. 2016

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Of late, several biologically active antioxidants from natural products have been investigated by the researchers in order to combat the root cause of carcinogenesis, i.e., oxidative stress. Mangiferin, a therapeutically active C-glucosylated xanthone, is extracted from pulp, peel, seed, bark and leaf of Mangifera indica. These polyphenols of mangiferin exhibit antioxidant properties and tend to decrease the oxygen-free radicals, thereby reducing the DNA damage. Indeed, its capability to modulate several key inflammatory pathways undoubtedly helps in stalling the progression of carcinogenesis. The current review article emphasizes an updated account on the patents published on the chemopreventive action of Mangiferin, apoptosis induction made on various cancer cells, along with proposed antioxidative activities and patent mapping of other important therapeutic properties. Considering it as promising polyphenol, this paper would also summarize the diverse molecular targets of Mangiferin.

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“…Based on the recent survey and review (Rajendran et al, 2015), we would confirm that this is the first study conducted to explore the anti-H. pyloric activity of MF on AGS cell line. The disk agar diffusion method was employed to investigate the anti-H. pyloric activity of MF (with different concentration) on H. pylori-infected AGS cells.…”

Section: Resultsmentioning

confidence: 80%

“…MFt a broad spectrum of pharmaceutical activities such as antioxidant, anti-inflammation, anti-microbial, anti-invasive, anti-tumor (Wauthoz et al, 2007;Singh et al, 2012;Anand et al, 2015). Enormous studies had indicated that MF might act as an anti-carcinogen in various cancer cell line model attributing to its antioxidant, anti-inflammatory, anti-proliferative (cytotoxic), anti-adhesive, and pro-apoptotic effect (Rajendran et al, 2015; du Plessis-Stoman et al, 2011). Moreover, the gastroprotective activity of mangiferin was reported in an animal model (Carvalho et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Inhibitory Activity of Mangiferin on Helicobacter Pylori-Induced Inflammation in Human Gastric Carcinoma Ags Cells

Zhang¹,

Yue²

2016

AJTCAM

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Background: Gastric cancer is a serious health issue caused by H. pylori and claims more lives in developing and undeveloped countries. Hence, the need for a natural drug with several pharmacological activities with no adverse effect are highly recommended. The target of this study was to verify the anti-H. pyloric efficacy of mangiferin (MF) on H. pyloriinfected AGS cells. Materials and methods: AGS cells were co-cultured with H. pylori and incubated with increased concentration of MF (10, 20, 50 and 100 µg/mL) or amoxicillin (AMX) and DMSO (control) group to assess its anti-H. pyloric effect by checking inhibitory zone, bacterial drug sensitivity test (MIC and MBC), adhesion and invasive property and various inflammatory markers. Results: Co-culturing of H. pylori-infected AGS cells with MF (100 µg) considerably increased (p<0.05) the inhibitory zone as well as substantially lowered (p<0.05) in the levels of MBC and MIC with decreased adhesion and invasive property in a dose-dependent manner and thus endorsing its anti H. pyloric activity and are almost equivalent to antibiotic AMX. Meanwhile, inflammatory markers such as NF-κB subunit p65, interleukins-1β, IL-8, and TNF-α were also markedly suppressed (p<0.01) on treatment with MF. In addition, the protein expression of inflammatory enzymes like COX-2 and iNOS were notably downregulated (p<0.05) in AGS cells incubated with MF. Conclusion: We, concluded that MF treatment with H. pylori-infected AGS cells significantly suppressed the adhesion and invasion process as well as deactivated NF-p65 thereby blocking inflammatory response and thus lower the incidence of gastric carcinoma.

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Mangiferin in cancer chemoprevention and treatment: pharmacokinetics and molecular targets

Cited by 58 publications

References 80 publications

Mangiferin: a natural miracle bioactive compound against lifestyle related disorders

Mangiferin: a natural miracle bioactive compound against lifestyle related disorders

Mangiferin: a Promising Anticancer Bioactive

Inhibitory Activity of Mangiferin on Helicobacter Pylori-Induced Inflammation in Human Gastric Carcinoma Ags Cells

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