Mangiferin: a natural miracle bioactive compound against lifestyle related disorders

Abstract

The current review article is an attempt to explain the therapeutic potential of mangiferin, a bioactive compound of the mango, against lifestyle-related disorders. Mangiferin (2-β-D-glucopyranosyl-1,3,6,7-tetrahydroxy-9H-xanthen-9-one) can be isolated from higher plants as well as the mango fruit and their byproducts (i.e. peel, seed, and kernel). It possesses several health endorsing properties such as antioxidant, antimicrobial, antidiabetic, antiallergic, anticancer, hypocholesterolemic, and immunomodulatory. It suppresses the activation of peroxisome proliferator activated receptor isoforms by changing the transcription process. Mangiferin protects against different human cancers, including lung, colon, breast, and neuronal cancers, through the suppression of tumor necrosis factor α expression, inducible nitric oxide synthase potential, and proliferation and induction of apoptosis. It also protects against neural and breast cancers by suppressing the expression of matrix metalloproteinase (MMP)-9 and MMP-7 and inhibiting enzymatic activity, metastatic potential, and activation of the β-catenin pathway. It has the capacity to block lipid peroxidation, in order to provide a shielding effect against physiological threats. Additionally, mangiferin enhances the capacity of the monocyte-macrophage system and possesses antibacterial activity against gram-positive and gram-negative bacteria. This review summarizes the literature pertaining to mangiferin and its associated health claims.

Chemical and Morphological Inter‐ and Intrapopulation Variability in Natural Populations of Gentiana pneumonanthe L.

“…Secoiridoid glycosides such as gentiopicrin (bitterness value of 12,000) are the characteristic bitter-tasting constituents of Gentiana species, exhibiting gastroprotective, hepatoprotective, anti-inflammatory and antibacterial effects. [39] Along with their pharmacological effects, xanthones have an important role as chemotaxonomic markers. Xanthones, which are also common constituents of Gentiana species, display various bioactivities, including CNS effects, antidepressant activity, [36] antitumor activity, [37] radioprotective activity, [38] etc.…”

“…The mangiferin xanthone, called a natural miracle bioactive compound, is reported as possessing protective effects against degenerative diseases such as atherosclerosis, cancers, obesity and diabetes. [39] Along with their pharmacological effects, xanthones have an important role as chemotaxonomic markers. Since the grade of substitution of xanthones is characteristic for a genus, and the oxidation pattern is uniform within a particular section, [40] xanthones are very useful in plant systematics and chemotaxonomy.…”

Mangiferin suppresses human metastatic osteosarcoma cell growth by down-regulating the expression of metalloproteinases-1/2 and parathyroid hormone receptor 1

“…However, toxic side effects and drug resistance are main disadvantage of paclitaxel which leads to major problem for their clinical application. Mangiferin is wellknown xanthone found in several mango fruits such as barks, peel, leaves, stone, stalks and kernel, and in higher plants (Imran et al 2017). Dar et al (2005) have reported the several pharmacological effects of mangiferin such as antioxidant, anticancer, antiaging, antiviral, hepatoprotective, analgesic and immunomodulatory potential.…”

Mahkota Dewa Subcritical Water Extraction Process: Experimental and Molecular Dynamics Simulation Study

“…Mahkota Dewa is a rich source of mangiferin, mahkoside A, mahkoside B, icariside C 3 , polyphenols, phenols, saponins, phalerins, alkaloids, flavonoids, lignans, tannins, and gallic acid [2][3][4][5]. Mangiferin has a great potential due to antioxidative, antidiabetic, antiviral, antiinflammatory, anticancer, antimicrobial, antiallergic, and also analgesic properties [6][7][8][9][10]. Despite numerous valuable bioactive effects, to date only a few studies reported on the extraction of mangiferin from Mahkota Dewa.…”