Manganese oxide increases bleaching efficacy and reduces the cytotoxicity of a 10% hydrogen peroxide bleaching gel

A new approach for professional dental bleaching using a polymeric catalyst primer

“…The use of chemical activators derived from MnO has been reported by several researchers 12,16,19 . This metal oxide participates in H 2 O 2 catalysis, promoting its degradation and producing other ROS 20,21,24,25 . The reaction mechanism of MnO with H 2 O 2 might occur through the process of manganese reduction by its own reactive molecule 22 : MnO 2 + H 2 O 2 → MnO (or Mn 2 O 3 ) + H 2 O.…”

“…In addition, the application of bleaching agents for 45 min, as performed in the present investigation, allows comparing our results with those data obtained from studies in which different strategies of H 2 O 2 degradation were tested using chemical catalytic agents associated or not to photocatalysis approach. 11,12,24,25,29 Even considering the methodological limitations of this in vitro study and that results from laboratory investigations should not be directly extrapolated to clinical situations, 5,35 the use of PCP containing MnO as a chemical catalyst of H 2 O 2 seems to be a promising strategy to reduce the cytotoxicity of professional dental bleaching therapies without harming the excellent esthetic results already reached with this modality of esthetic treatment. However, clinical trial are still needed to assess the safety of use and EE of associating PCP with bleaching gels commonly employed in dental offices.…”

“…12,16,19 This metal oxide participates in H 2 O 2 catalysis, promoting its degradation and producing other ROS. 20,21,24,25 The reaction mechanism of MnO with tion. 17 In the present study, it was observed that PCP potentiated the kinetics of H 2 O 2 degradation, resulting in a greater production of OH • radicals.…”

“…Considering that MnO may be effectively used in different tooth bleaching protocols, it is essential at this time, to determine the potential benefits of this metal oxide for bleaching outcomes and pulp cell protection against the toxic effects of H 2 O 2 . Recent investigations showed that the presence of MnO in bleaching gels increases the degradation rate of H 2 O 2 molecules, that result in enhanced EE and reduced cytotoxic of this therapy 24,25 . Thus, the present study added MnO to a cellulose‐derived nontoxic semisynthetic polymer, which has been extensively used in the pharmaceutical industry for controlled drug release 26,27 .…”

“…Recent investigations showed that the presence of MnO in bleaching gels increases the degradation rate of H 2 O 2 molecules, that result in enhanced EE and reduced cytotoxic of this therapy. 24,25 Thus, the present study added MnO to a cellulosederived nontoxic semisynthetic polymer, which has been extensively used in the pharmaceutical industry for controlled drug release. 26,27 The strategy of developing bioproducts containing catalyst molecules, which are applied on enamel before the bleaching gels, has already been reported in the literature.…”