Manganese neurotoxicity and the role of reactive oxygen species

Martinez-Finley, Ebany J.; Gavin, Claire E.; Aschner, Michael; Gunter, Thomas E.

doi:10.1016/j.freeradbiomed.2013.01.032

Cited by 269 publications

(158 citation statements)

References 180 publications

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“…Most attention regarding Mn toxicity has been directed towards nerve cells, as reviewed by Gerber et al (19). The upstream molecular mechanisms involved are not yet fully known but the induced toxicity is known to be associated with oxidative stress (20)(21)(22). Formation of reactive oxygen species causes DNA damage (23,24), arrests cell proliferation and activates transcription factors triggering apoptosis (25).…”

Section: Discussionmentioning

confidence: 99%

Manganese Inhibits Viability of Prostate Cancer Cells

Hernroth

Holm

Gondikas

et al. 2018

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Section: Discussionmentioning

confidence: 99%

Manganese Inhibits Viability of Prostate Cancer Cells

Hernroth

Holm

Gondikas

et al. 2018

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“…Moreover, human and animal food chains can be contaminated by unsanitary storage of solid wastes and waste water (9,18). In addition, disruption of the antioxidant defense system by toxic levels of heavy metals may affect human health (24)(25)(26).…”

Section: Discussionmentioning

confidence: 99%

Comparing levels of certain heavy metals and minerals and antioxidativemetabolism in cows raised near and away from highways*

Ekici¹,

Şimşek²,

Arıkan³

et al. 2015

Turk J Vet Anim Sci

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IntroductionHeavy metals are elements with a density higher than 5 g/cm 3 or with an atomic weight larger than 50 (1). Heavy metals are known to be chemicals extremely dangerous to living organisms. Large quantities of heavy metals are discharged each day in various ways and reach the rivers, lakes, and seas (2).Environment and soil in which the food consumed was grown and water involved in the cultivation are of importance regarding the intake of these metals. Tissue damage or even mortality might occur as a result of heavy metal accumulation in the biological tissues such as liver, kidney, and brain and body fluids of animals that are fed on plants grown in soils with dense industrial pollution and vehicle traffic (1,2).Currently, it is known that heavy metal ions lead to serious health problems; they even cause death in some cases. Therefore, it is important to focus on heavy metal contamination, and it is necessary to examine various sources and concentrations of heavy metals in foods and to take effective precautions (3). Heavy metals, most of which are necessary for organisms, bind to cell structure in very low concentrations. However, higher concentrations of these heavy metals might produce toxic effects by inhibition of enzyme systems in organisms. Mercury (Hg), lead (Pb), cadmium (Cd), and copper (Cu), in particular, have greater toxicity (4,5).Factors that affect the degree of heavy metal toxicity include the form of the metal, the presence of other metals and poisons, environmental factors (pH, temperature, oxygen, etc.), life-stage and sex of the organism, etc. (6). While some metals such as arsenic (As), Cd, Hg, molybdenum (Mo), Pb, and selenium (Se) are extremely toxic, some of them have carcinogenic [As, Cd, chromium (Cr), nickel (Ni), Pb, Se], mutagenic, and teratogenic effects. In addition, Cd stimulates free radical production by oxidative deterioration of lipids and Pb may lead to damage as a result of disruption of the equilibrium between oxidants and antioxidants in mammalian cells (7).

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“…Patients may be asymptomatic for months or years after exposure, but progressively develop slow movements, irritability, aggressiveness, and hallucinations. By later stage, features include extrapyramidal syndrome that is unresponsive to L-dopa, tremor, balance disturbances with a dystonic cock-walk gait and postural instability, facial muscle spasms and cognitive impairment [93,94].…”

Section: Manganese and Central Nervous Systemmentioning

confidence: 99%

Bioavailable Trace Metals in Neurological Diseases

Poujois

Devedjian

Moreau

et al. 2016

Curr Treat Options Neurol

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Opinion statement  Medical treatment in Wilson's disease includes chelators (D-Penicillamine andTrientine) or zinc salts that have to be maintain all the lifelong. This pharmacological treatment is categorized into two phases; the first being a decoppering phase and the second a maintenance's one. The best therapeutic approach remains controversial, as only a few non-controlled trials have compared these treatments. During the initial phase, progressive increase of chelators' doses adjusted to exchangeable copper and urinary copper might help to avoid neurological deterioration. Liver transplantation is indicated in acute fulminant liver failure and decompensated cirrhosis; in cases of neurologic deterioration, it must be individually discussed. During the maintenance phase, the most important challenge is to obtain a good adherence to lifelong medical therapy. Neurodegenerative diseases that lead to a mislocalization of iron can be caused by a culmination of localized overload (pro-oxidant siderosis) and localized deficiency (metabolic distress). A new therapeutic concept with conservative iron chelation rescues iron-overloaded neurons by scavenging labile iron and, by delivering this chelated metal to endogenous apotransferrin, allows iron redistribution to avoid systemic loss of iron.

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Manganese neurotoxicity and the role of reactive oxygen species

Cited by 269 publications

References 180 publications

Manganese Inhibits Viability of Prostate Cancer Cells

Manganese Inhibits Viability of Prostate Cancer Cells

Comparing levels of certain heavy metals and minerals and antioxidativemetabolism in cows raised near and away from highways*

Bioavailable Trace Metals in Neurological Diseases

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