Manganese in autism spectrum disorder and attention deficit hyperactivity disorder: The state of the art

Aschner, Michael; Martins, Airton C.; Oliveira-Paula, Gustavo H.; Skalny, Anatoly V.; Zaitseva, Irina P.; Bowman, Aaron B.; Kirichuk, Anatoly A.; Santamaria, Abel; Tizabi, Yousef; Tinkov, Alexey A.

doi:10.1016/j.crtox.2024.100170

Cited by 3 publications

(1 citation statement)

References 209 publications

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“…Early life exposure to high levels of Mn is thought to impact neurodevelopment, especially cognitive behavior in children [127]. Importantly, high Mn exposure and alteration in the GM has been linked to oxidative stress and neuroinflammation, which are implicated in HD [128,129].…”

Section: Manganese (Mn) -Hdmentioning

confidence: 99%

Heavy Metals Interactions with Neuroglia and Gut Microbiota: Implications for Huntington’s Disease

Tizabi,

Bennani,

El Kouhen

et al. 2024

Preprint

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Huntington’s disease (HD) is a rare but progressive and devastating neurodegenerative disease characterized by involuntary movements, cognitive decline, executive dysfunction, and neuropsychiatric conditions such as anxiety and depression. It follows an autosomal dominant inheritance pattern. Thus, a child who has a parent with the mutated huntingtin (mHTT) gene has a 50% chance of developing the disease. Since HTT protein is involved in many critical cellular processes including neurogenesis, brain development, energy metabolism, transcriptional regulation, synaptic activity, vesicle trafficking, cell signaling, and autophagy, its aberrant aggregates lead to disruption of numerous cellular pathways and neurodegeneration. Essential heavy metals are vital at low concentrations, however, at higher concentrations, can exacerbate HD by disrupting the glial-neuronal communication, and/or causing dysbiosis (disturbance in the gut microbiota, GM), both of which can lead to neuroinflammation and further neurodegeneration. Here, we discuss in detail the interactions of iron, manganese and copper with glial-neuron communication and GM and indicate how this knowledge may pave the way for development of a new generation of disease-modifying therapies in HD.

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Section: Manganese (Mn) -Hdmentioning

confidence: 99%

Heavy Metals Interactions with Neuroglia and Gut Microbiota: Implications for Huntington’s Disease

Tizabi,

Bennani,

El Kouhen

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

Maternal choline supplementation in neurodevelopmental disorders: mechanistic insights from animal models and future directions

King,

Plakke

2024

Nutritional Neuroscience

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Heavy Metal Interactions with Neuroglia and Gut Microbiota: Implications for Huntington’s Disease

Tizabi,

Bennani,

El Kouhen

et al. 2024

Cells

View full text Add to dashboard Cite

Huntington’s disease (HD) is a rare but progressive and devastating neurodegenerative disease characterized by involuntary movements, cognitive decline, executive dysfunction, and neuropsychiatric conditions such as anxiety and depression. It follows an autosomal dominant inheritance pattern. Thus, a child who has a parent with the mutated huntingtin (mHTT) gene has a 50% chance of developing the disease. Since the HTT protein is involved in many critical cellular processes, including neurogenesis, brain development, energy metabolism, transcriptional regulation, synaptic activity, vesicle trafficking, cell signaling, and autophagy, its aberrant aggregates lead to the disruption of numerous cellular pathways and neurodegeneration. Essential heavy metals are vital at low concentrations; however, at higher concentrations, they can exacerbate HD by disrupting glial–neuronal communication and/or causing dysbiosis (disturbance in the gut microbiota, GM), both of which can lead to neuroinflammation and further neurodegeneration. Here, we discuss in detail the interactions of iron, manganese, and copper with glial–neuron communication and GM and indicate how this knowledge may pave the way for the development of a new generation of disease-modifying therapies in HD.

show abstract

Manganese in autism spectrum disorder and attention deficit hyperactivity disorder: The state of the art

Cited by 3 publications

References 209 publications

Heavy Metals Interactions with Neuroglia and Gut Microbiota: Implications for Huntington’s Disease

Heavy Metals Interactions with Neuroglia and Gut Microbiota: Implications for Huntington’s Disease

Maternal choline supplementation in neurodevelopmental disorders: mechanistic insights from animal models and future directions

Heavy Metal Interactions with Neuroglia and Gut Microbiota: Implications for Huntington’s Disease

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