Manganese(III)-salens induce tumor selective apoptosis in human cells

A novel β-diiminato manganeseIII complex as the promising anticancer agent induces G0/G1 cell cycle arrest and triggers apoptosis via mitochondrial-dependent pathways in MCF-7 and MDA-MB-231 human breast cancer cells

“…Consequently, Mn-based complexes have been considered as a valuable source for the development of new anticancer agents. [19][20][21][22] On the other hand, ligands can modify the biological properties through the limitation of the side effects of metal ion overload and assist metal ion redistribution. [23][24][25] b-Diiminates are the wonderful class of chelating ligands.…”

Nitro complexos de ferro(III) com derivados da base de Schiff Salen

“…Os complexos com ligantes salen e derivados são amplamente estudados devido as suas diferentes aplicações em catálise, atuando em reações de oxidação, redução e polimerização (GHAFFARI et al, 2014). No que se refere à atividade biológica, foi identificado que estes compostos apresentam ação citotóxica frente a tumores malignos MANDAL, 2008;LEE et al, 2011;ANSARI et al, 2009), bem como a capacidade de fragmentar o DNA (DEHKORDI; LINCOLN, 2013).…”

Interaction of manganese(II) complex with apotransferrin and the apotransferrin enhanced anticancer activities

“…Transporting mechanism of Mn(II) in vivo makes Mn(II)-based compounds possible to be tumor-targeted. Biochemically active Mn(III)-salen and Mn(III)-salphen compounds were reported to induce nuclear fragmentation and apoptosis of HeLa cells [6]. Recently, we found that Mn(II) compounds with N-substituted di(picolyl)amine inhibits the proliferation of human glioma cells (U251) and HepG-2 cells in vitro.…”