Interaction of manganese(II) complex with apotransferrin and the apotransferrin enhanced anticancer activities

Yao, Ling; Chen, Qiuyun; Xu, Xiaoling; Li, Zan; Wang, Xue-Ming

doi:10.1016/j.saa.2012.12.029

Cited by 7 publications

(4 citation statements)

References 28 publications

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“…This selectivity of PEG-Mn-BDA may be due to its ability to induce cell death via different pathways and its excellent transport system into the cells. Studies have shown that iron transport proteins such as transferrin receptors are over expressed on cancer cells [33,34], and manganese complexes are transported into cancer cells using the same transport system [35]. PEG-Mn-BDA is therefore suspected to be transported into the SMMC-7721 cells by these iron transport proteins.…”

Section: Discussionmentioning

confidence: 99%

A mitochondria targeting Mn nanoassembly of BODIPY for LDH-A, mitochondria modulated therapy and bimodal imaging of cancer

Boison¹,

et al. 2016

Colloids and Surfaces B: Biointerfaces

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HIF-1α and LDH-A are important targets for hypoxia-driven drug resistance. Mitochondria targeted fluorescent manganese(II)-complexes can be used as potential fluorescence imaging agents, MRI contrast agents and HIF-1α and LDH-A involved anticancer complexes. In this study, a fluorescent manganese(II) nanoparticle, labeled as (PEG-Mn-BDA), was synthesized and used as both fluorescent and MRI imaging agents in cancer cells. In vitro bioassay results indicate that PEG-Mn-BDA was able to inhibit LDH-A activity and depolarize mitochondrial membrane potential with the generation of intracellular ROS, which contributed to the induction of apoptosis. Moreover, the pro-apoptotic protein, caspase 3 was highly expressed. In vivo, PEG-Mn-BDA could also exert inhibition on a mouse hepatocellular carcinoma xenograft. These results suggest that mitochondria targeted PEG-Mn-BDA was able to simultaneously induce selective inhibition on cancer cells and a mouse carcinoma xenograft, label cancer cells with fluorescence and enhance MRI contrast. Therefore, PEG-Mn-BDA is a good candidate for cancer treatment and imaging.

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Section: Discussionmentioning

confidence: 99%

A mitochondria targeting Mn nanoassembly of BODIPY for LDH-A, mitochondria modulated therapy and bimodal imaging of cancer

Boison¹,

et al. 2016

Colloids and Surfaces B: Biointerfaces

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“…Therefore, it can be speculated that Mn(II) complexes could exert their antitumor action by specifically impairing the transport mechanism of TfR proteins. 12 In recent years, various binuclear Mn(II) complexes have been synthesized with diverse ligand scaffolds and shown to exhibit remarkable cytotoxic activity in vitro. 13,14 Zinc features as the 2nd most prevalent trace-metal element in the human body and is actively involved in the DNA synthesis and repair mechanisms, cell metabolism, and defense against oxidative damage.…”

Section: Introductionmentioning

confidence: 99%

“… 11 Therefore, it can be speculated that Mn(II) complexes could exert their antitumor action by specifically impairing the transport mechanism of TfR proteins. 12 In recent years, various binuclear Mn(II) complexes have been synthesized with diverse ligand scaffolds and shown to exhibit remarkable cytotoxic activity in vitro . 13 , 14 …”

Section: Introductionmentioning

confidence: 99%

“…Notably, many literature reports have revealed transferrin receptor (TfR) proteins (which are highly expressed in tumor cells) essential for the cellular uptake and transport of Mn(II) ions in vivo . Therefore, it can be speculated that Mn(II) complexes could exert their antitumor action by specifically impairing the transport mechanism of TfR proteins . In recent years, various binuclear Mn(II) complexes have been synthesized with diverse ligand scaffolds and shown to exhibit remarkable cytotoxic activity in vitro . , …”

Section: Introductionmentioning

confidence: 99%

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Syntheses, Structural Characterization, and Cytotoxicity Assessment of Novel Mn(II) and Zn(II) Complexes of Aroyl-Hydrazone Schiff Base Ligand

2023

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This work describes the syntheses, structural characterization, and biological profile of Mn(II)- and Zn(II)-based complexes 1 and 2 derived from the aroyl-hydrazone Schiff base ligand (L1). The synthesized compounds were thoroughly characterized by elemental analysis, Fourier transform infrared spectroscopy (FTIR), UV–vis, electron paramagnetic resonance (EPR), nuclear magnetic resonance (NMR), and single-crystal X-ray diffraction (s-XRD). Density functional theory (DFT) studies of complexes 1 and 2 were performed to ascertain the structural and electronic properties. Hirshfeld surface analysis was used to investigate different intermolecular interactions that define the stability of crystal lattice structures. To ascertain the therapeutic potential of complexes 1 and 2, in vitro interaction studies were carried out with ct-DNA and bovine serum albumin (BSA) using analytical and multispectroscopic techniques, and the results showed more avid binding of complex 2 than complex 1 and L1. The antioxidant potential of complexes 1 and 2 was examined against the 2,2-diphenyl picrylhydrazyl (DPPH) free radical, which revealed better antioxidant ability of the Mn(II) complex. Moreover, the antibacterial activity of synthesized complexes 1 and 2 was tested against Gram-positive and Gram-negative bacteria in which complex 2 demonstrated more effective bactericidal activity than L1 and complex 1 toward Gram-positive bacteria. Furthermore, the in vitro cytotoxicity assessment of L1 and complexes 1 and 2 was carried out against MDA-MB-231 (triple negative breast cancer) and A549 (lung) cancer cell lines. The cytotoxic results revealed that the polymeric Zn(II) complex exhibited better and selective cytotoxicity against the A549 cancer cell line as was evidenced by its low IC50 value.

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Structure and magnetism of a Mn(iii)–Mn(ii)–Mn(ii)–Mn(iii) chain complex

et al. 2013

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A novel tetranuclear manganese(II/III) complex with anions of pyridine-2,6-dicarboxylic acid (dipicolinic acid) has been synthesised and magneto-structurally characterised. The crystal structure of [Mn(II)2Mn(III)2(dipic)6(H2O)4]·2CH3OH·4H2O has been determined by single-crystal X-ray diffraction. The tetranuclear complex molecule [Mn(II)2Mn(III)2(dipic)6(H2O)4] is centrosymmetric and two manganese(II) and two manganese(III) atoms are bridged by four dipicolinate ligands. The complex molecules and uncoordinated water and methanol molecules are connected through hydrogen bonds and they form a 3D supramolecular hydrogen-bonding network.

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Interaction of manganese(II) complex with apotransferrin and the apotransferrin enhanced anticancer activities

Cited by 7 publications

References 28 publications

A mitochondria targeting Mn nanoassembly of BODIPY for LDH-A, mitochondria modulated therapy and bimodal imaging of cancer

A mitochondria targeting Mn nanoassembly of BODIPY for LDH-A, mitochondria modulated therapy and bimodal imaging of cancer

Syntheses, Structural Characterization, and Cytotoxicity Assessment of Novel Mn(II) and Zn(II) Complexes of Aroyl-Hydrazone Schiff Base Ligand

Structure and magnetism of a Mn(iii)–Mn(ii)–Mn(ii)–Mn(iii) chain complex

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