Manganese dioxide nanozyme for reactive oxygen therapy of bacterial infection and wound healing

Abstract

Reactive oxygen species (ROS) are the weapon of neutrophiles against bacterial pathogens, and also the central effector in the reactive oxygen therapy for skin and soft tissue infection. Nanozymes that...

Dendritic Mesoporous Silica Nanoparticle-Tuned High-Affinity MnO2 Nanozyme for Multisignal GSH Sensing and Target Cancer Cell Detection

“…Based on the GSH-mediated blue color fading of oxTMB, the absorbance and brightness of the available oxTMB could be used to develop the UV–vis and colorimetry method. According to the published results, the MnO 2 nanozyme could generate the O 2 – , which catalyzed the oxidization of TMB in the presence of oxygen and produced a deep blue color. To verify the O 2 – generation in our designed nanozyme, the ROS trapper DPBF was used to test the O 2 – content.…”

“…Based on the GSH-mediated blue color fading of oxTMB, the absorbance and brightness of the available oxTMB could be used to develop the UV−vis and colorimetry method. According to the published results, 50 − . 51 As shown in Figure 5C, compared with the SODnonexistent group, the SOD-containing group demonstrated decreased fluorescence intensity of DCFH-DA, which verified the O 2 − generation.…”

Recent advances in nanozymes for combating bacterial infection

“…In addition, compared with vancomycin, the OA–MnO 2 nanozyme has a good ability to prevent and disrupt S. aureus biofilm formation and superior antibacterial properties in vivo . 94 Two types of copper/carbon nanozymes have been found to have copper state-dependent catalase, peroxidase, and superoxide dismutase-like activities. Furthermore, the copper state also determines antimicrobial activity.…”

Recent Trends in Composite Nanozymes and Their Pro-Oxidative Role in Therapeutics

“…Liu et al have studied the effect of surface plasmon resonance (SPR) on activating the POD-like activity of CeO 2 for antibacterial action. Au@CeO 2 nanozymes were synthesized with low oxidase and peroxidase-like activity, which was enhanced three times after 808-nm laser irradiation as compared to only CeO 2 NPs or Au nanorods at weekly acidic pH ( Liu et al, 2021 ). Xu et al synthesized a multifunctional platform enabling photothermal/chemodynamic/pharmaco-synergistic antibacterial action by encapsulating tungsten sulfide quantum dot (WS 2 QD) nanozyme and vancomycin antibiotic in a thermal-sensitive liposome.…”