Manganese dioxide (MnO<sub>2</sub>) based nanomaterials for cancer therapies and theranostics

Zhu, Dan; Zhu, Xiaohua; Ren, Shen-Zhen; Lu, Yinan; Zhu, Hai‐Liang

doi:10.1080/1061186x.2020.1815209

Cited by 36 publications

(25 citation statements)

References 80 publications

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“…Furthermore, compared with the control group, the group treated with MnO x and MD@BSA has consumed more GSH due to the high valence states of Mn, which inhibited GPX4 expression and ultimately induced ferroptosis. [ 29,30 ] In combination, all these results confirmed that antitumor effect from MD@BSA was attributed to the combined Dnase‐I‐mediated protein therapy, Mn 2+ ‐induced CDT, and GSH‐depletion ferroptosis.…”

Section: Resultsmentioning

confidence: 56%

“…[24][25][26][27] Particularly, MnO x nanoflowers have been more widely used to load anticancer drugs, antibodies, and other substances for tumor microenvironment (TME)-responsive combined therapy due to their outstanding properties such as the high drug loading capacity, [28] the preeminent property of glutathione (GSH)-responsive drug release, [29] Mn 2þ -induced CDT, and GSH-depleting ferroptosis. [30] For example, He et al reported floriated MnO x -based nanomaterials for GSH-responsive drugs (catalase, chlorin e6, and DNAzymes) release and combined multiplex tumor therapy, which demonstrated that MnO x nanoflowers were an excellent drug carrier. [31] In addition, MnO x -based nanomaterials not only exhibited the ability to escape from lysosome, which could effectively avoid the inactivation of anticancer proteins, but also showed GSH-responsive magnetic resonance imaging (MRI), which was beneficial to confirm the tumor diagnosis and monitor tumor therapy.…”

Section: Introductionmentioning

confidence: 99%

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GSH‐Responsive Dnase‐I‐Loaded MnO_xNanoplatforms for Combined Protein‐Chemodynamic Therapy

Zhang

Sun

et al. 2022

Advanced NanoBiomed Research

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The effective delivery of protein therapeutics remains a major challenge. Here, the novel nanoplatforms with bovine serum albumin (BSA)‐coated, Dnase‐1‐loaded MnOx nanoflowers are developed (denominated MD@BSA). These MD@BSA nanoplatforms present a highly efficient protein loading and effective delivery Dnase‐I into tumor cells. Under the glutathione (GSH) overexpression environment, MD@BSA is degradable, resulting in Dnase‐1 and Mn2+ release for combining protein therapeutics and chemodynamic therapy (CDT), and the GSH‐responsive MR imaging in vivo and vitro that could be used to trace and evaluate the severity of tumor for therapeutic regimen adjustment. This method offers a facile and GSH‐responsive strategy for both delivering proteins and enhanced treatment effect via combined protein‐CDT, which may contribute to the clinical application of protein therapeutics in the future.

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Section: Resultsmentioning

confidence: 56%

Section: Introductionmentioning

confidence: 99%

GSH‐Responsive Dnase‐I‐Loaded MnO_xNanoplatforms for Combined Protein‐Chemodynamic Therapy

Zhang

Sun

et al. 2022

Advanced NanoBiomed Research

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“…For this reason, smart biocatalytic cascade systems designed such as well-assembled multicatalytic nanoreactors have been interested. These systems can supply a large amount of molecular oxygen as a substrate for PDT and also provide more effective communication between catalyst and substrate in these systems [27,[34][35][36].…”

Section: O 2 Self-enriched Metal-based Nanoplatform For Pdt Improvingmentioning

confidence: 99%

Metal-Based Nanomaterials Photodynamic Action with a Focus on Au and Ag Nanomaterials

Nomani¹,

Kianmehr²,

Abdoli³

et al. 2023

Drug Formulation Design

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Photodynamic action is the interaction between cells and oxygen, light, and chemical reagent (photosensitizers). Photodynamic techniques include photodynamic diagnosis (PDD), fluorescence-guided tumor resection, and photodynamic therapy (PDT). PDD and PDT have the exact mechanism. They are based on light and tissue interaction with a difference. PDT is along with the destruction of the lesion against PDD that the diagnosis is made without destruction. Photosensitizers (PSs) could be organic and inorganic. Metal-based PSs were considered, due to the disadvantages of organic PSs such as low quantum yield and small stock shift, and high toxicity. We have examined the metal-based nanomaterials PDT in recent years. The titles considered are including the introduction that consists of explanations about photodynamic action, PDD, PDT and history of PDT, PDT mechanism, PDT effects on the immune system, photosensitizers, and metal-based nanomaterials in the photodynamic application, which this section addresses along with the application of metal nanomaterials (with a focus on gold and silver nanomaterials) in photodynamic techniques.

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“…The MnO 2 nanostructure is highly sensitive to the TME and rapidly degrades in the reduced and acidic environment, which is why it can be used as a tumor-specific drug vehicle. In addition, MnO 2 is shown to catalyze H 2 O 2 overproduced in tumor cells to produce O 2 in situ and overcome TME hypoxia ( Wu M. et al, 2019b ; Zhu et al, 2020 ). Zhu et al constructed a composite core–shell-structured nanozyme (MS-ICG@MnO 2 @PEG) having indocyanine green (ICG) loaded as a photosensitizer in the MnO 2 shell for photodynamic therapy (PDT) clubbed with ROS-mediated chemodynamic therapy ( Zhu et al, 2020 ).…”

Section: Composite Nanozymes With Pro-oxidative Potentialmentioning

confidence: 99%

Recent Trends in Composite Nanozymes and Their Pro-Oxidative Role in Therapeutics

Maddheshiya

Nara

2022

Front. Bioeng. Biotechnol.

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Nanozymes are inorganic nanostructures whose enzyme mimic activities are increasingly explored in disease treatment, taking inspiration from natural enzymes. The catalytic ability of nanozymes to generate reactive oxygen species can be used for designing effective antimicrobials and antitumor therapeutics. In this context, composite nanozymes are advantageous, particularly because they integrate the properties of various nanomaterials to offer a single multifunctional platform combining photodynamic therapy (PDT), photothermal therapy (PTT), and chemodynamic therapy (CDT). Hence, recent years have witnessed great progress in engineering composite nanozymes for enhanced pro-oxidative activity that can be utilized in therapeutics. Therefore, the present review traverses over the newer strategies to design composite nanozymes as pro-oxidative therapeutics. It provides recent trends in the use of composite nanozymes as antibacterial, antibiofilm, and antitumor agents. This review also analyzes various challenges yet to be overcome by pro-oxidative composite nanozymes before being used in the field.

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Manganese dioxide (MnO₂) based nanomaterials for cancer therapies and theranostics

Cited by 36 publications

References 80 publications

GSH‐Responsive Dnase‐I‐Loaded MnO_xNanoplatforms for Combined Protein‐Chemodynamic Therapy

GSH‐Responsive Dnase‐I‐Loaded MnO_xNanoplatforms for Combined Protein‐Chemodynamic Therapy

Metal-Based Nanomaterials Photodynamic Action with a Focus on Au and Ag Nanomaterials

Recent Trends in Composite Nanozymes and Their Pro-Oxidative Role in Therapeutics

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Manganese dioxide (MnO2) based nanomaterials for cancer therapies and theranostics

Cited by 36 publications

References 80 publications

GSH‐Responsive Dnase‐I‐Loaded MnOxNanoplatforms for Combined Protein‐Chemodynamic Therapy

GSH‐Responsive Dnase‐I‐Loaded MnOxNanoplatforms for Combined Protein‐Chemodynamic Therapy

Metal-Based Nanomaterials Photodynamic Action with a Focus on Au and Ag Nanomaterials

Recent Trends in Composite Nanozymes and Their Pro-Oxidative Role in Therapeutics

Contact Info

Product

Resources

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Manganese dioxide (MnO₂) based nanomaterials for cancer therapies and theranostics

GSH‐Responsive Dnase‐I‐Loaded MnO_xNanoplatforms for Combined Protein‐Chemodynamic Therapy

GSH‐Responsive Dnase‐I‐Loaded MnO_xNanoplatforms for Combined Protein‐Chemodynamic Therapy