Manganese as a potential marker of atherogenesis

Lozhkin, Andrey; Biktagirov, Timur; Abdul’yanov, V. A.; Voloshin, A. V.; Silkin, N. I.; Khairullin, R. N.; Салахов, М. Х.; Ilinskaya, О. N.

doi:10.1134/s1607672910050091

Cited by 3 publications

(2 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In papers of Lozhkin et al [29, 30], human aorta specimens obtained from autopsy of patients with atherosclerosis were investigated. A negative correlation between the concentration of manganese ions and degree of AP calcification was found.…”

Section: Discussionmentioning

confidence: 99%

“…Lozhkin et al speculated that the decrease in the manganese content with the increasing of AP calcification could be connected with the deficiency of mitochondrial Mn-SOD [29, 30]. However, now this assumption does not seem to be quite reasonable, because it is apparently not all of Mn 2+ in AP has intracellular localization being in the mitochondrial Mn-SOD.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Paramagnetic Manganese in the Atherosclerotic Plaque of Carotid Arteries

Chelyshev

Gafurov

Ignatiev

et al. 2016

BioMed Research International

View full text Add to dashboard Cite

The search for adequate markers of atherosclerotic plaque (AP) instability in the context of assessment of the ischemic stroke risk in patients with atherosclerosis of the carotid arteries as well as for solid physical and chemical factors that are connected with the AP stability is extremely important. We investigate the inner lining of the carotid artery specimens from the male patients with atherosclerosis (27 patients, 42–64 years old) obtained during carotid endarterectomy by using different analytical tools including ultrasound angiography, X-ray analysis, immunological, histochemical analyses, and high-field (3.4 T) pulse electron paramagnetic resonance (EPR) at 94 GHz. No correlation between the stable and unstable APs in the sense of the calcification is revealed. In all of the investigated samples, the EPR spectra of manganese, namely, Mn2+ ions, are registered. Spectral and relaxation characteristics of Mn2+ ions are close to those obtained for the synthetic (nano) hydroxyapatite species but differ from each other for stable and unstable APs. This demonstrates that AP stability could be specified by the molecular organization of their hydroxyapatite components. The origin of the obtained differences and the possibility of using EPR of Mn2+ as an AP stability marker are discussed.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%