Investigation of atherosclerotic plaque by high-frequency EPR

Biktagirov, Timur; Chelyshev, Yu. A.; Gafurov, Marat; Mamin, G. V.; Orlinskiĭ, S. B.; Osin, Yu. N.; Салахов, М. Х.

doi:10.1088/1742-6596/478/1/012002

Cited by 4 publications

(2 citation statements)

References 15 publications

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“…For X-band at T = 298 K spin-lattice (longitudinal) relaxation In [29] it was proposed that the HAp components of the aorta organomineralic matrix could serve at least as markers for the diagnosis of the atherosclerotic plaque formation/rupture risks. Advantages of the increased resolution and sensitivity of the HF 80 EPR methods in comparison to the conventional X-band were applied to detect and quantify the tissues containing the carbonate radicals in nano-HAp inclusions for the early diagnosis, to investigate spectral and relaxation characteristics of the naturally existing manganese or intentionally incorporated lead ions and to 85 establish their locations in atherosclerotic plaque and nano-HAp structures [18,[30][31][32][33][34]. W-band FS-ESE detected EPR spectrum of the 20 nm sample at T = 50 K is presented in Fig.…”

Section: Resultsmentioning

confidence: 99%

Nitrogen-containing species in the structure of the synthesized nano-hydroxyapatite

et al. 2014

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Synthesized by the wet chemical precipitation technique hydroxyapatite powders (HAp) with the sizes of the crystallites of (20-10 50) nm and 1 m were analyzed by multi-frequency (9 and 95 GHz) electron paramagnetic resonance (EPR) methods. It is shown that during the synthesis process nitrate anions from the reagents (by-products) could incorporate into the HAp structure. The relaxation times and EPR parameters of the axially symmetric NO 3 2paramagnetic centers detected after X-ray irradiation of the product at room temperature are measured with high accuracy. Assignments of the observed EPR spectra as compared with that given in literature are discussed. Analyses of electron-nuclear double resonance (ENDOR) data from 1 H and 31 P nuclei and ab-15 initio density functional theory (DFT) calculations allow suggesting that the paramagnetic centers and nitrate anions as the precursors of NO 3 2radicals preferably occupy PO 4 3site in the HAp structure. 65 110 Troullier-Martins pseudopotentials [27] with the plane-wave cutoff energy of 70 Ry.

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Section: Resultsmentioning

confidence: 99%

Nitrogen-containing species in the structure of the synthesized nano-hydroxyapatite

et al. 2014

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“…The inflammation and signaling pathways can be detected for earlier detection of cardiovascular diseases. [ 144 ] The Apolipoprotein‐B, proteins were shuttled cholesterol and triglycerides around the circulatory system by evading immune control and produced pro‐inflammatory signals, (Figure 13). For example, it may transform into artery cancer, but it is possible that during the formation of the plaque, the blood flow will slow down to influence the pumping and lead to a heart attack before it gains the last stage.…”

Section: Nano‐stem Cell Interface For Tracking and Probing Arteriosclmentioning

confidence: 99%

The convergence of nanotechnology‐stem cell, nanotopography‐mechanobiology, and biotic‐abiotic interfaces: Nanoscale tools for tackling the top killer, arteriosclerosis, strokes, and heart attacks

Kumar

Gulia

2020

Nano Select

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The nanotechnology‐stem cell has enabled the engineering of nanotopographical surfaces for mimicking the topological features of nano‐stem cell interfaces and stem cell niches. The nanotechnology‐stem cell, an abiotic–biotic model, the impact of the multi‐functional materials underlying support on nanomaterials interactions with stem cells plays a significant role in the development of the nanoscale tools for tracking the top killer, arteriosclerosis, strokes, and heart attacks. The biomimetic topographical surfaces, employed in cell mechanobiology (cell adhesions, migrations, and differentiation) and tissue engineering. The conformational features of the scaffold (ridges, grooves, whorls, pits, and pores, and symmetry) alter stem cell behavior and differentiation. Biomedical engineering is offering promises and explaining how the convergence of nanotechnology and stem cells has emerged as novel therapeutics. The analysis of mechanotransduction and tissue engineering is the key factor, which altogether influence the stem cell niche, can be considered for originating nanno‐stem cell interface, and a useful remedy for treating cardiovascular diseases. The Hippo pathway underlined the signaling cascade responsible for inhibiting cell proliferation. Notch signaling is a key pathway that regulates the modulation of cardiomyocyte survival, cardiac stem cell differentiation. The Wnt/β‐catenin signaling involved in chronic infusion of angiotensin II (Ang II), cardiomyocytes, and cardiac fibroblasts.

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Conventional, pulsed and high-field electron paramagnetic resonance for studying metal impurities in calcium phosphates of biogenic and synthetic origins

Gabbasov

Gafurov

Starshova

et al. 2019

Journal of Magnetism and Magnetic Materials

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Investigation of atherosclerotic plaque by high-frequency EPR

Cited by 4 publications

References 15 publications

Nitrogen-containing species in the structure of the synthesized nano-hydroxyapatite

Nitrogen-containing species in the structure of the synthesized nano-hydroxyapatite

The convergence of nanotechnology‐stem cell, nanotopography‐mechanobiology, and biotic‐abiotic interfaces: Nanoscale tools for tackling the top killer, arteriosclerosis, strokes, and heart attacks

Conventional, pulsed and high-field electron paramagnetic resonance for studying metal impurities in calcium phosphates of biogenic and synthetic origins

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