Mandibular sarcoma as a second neoplasm following radiotherapy for a nasopharyngeal carcinoma in childhood (Case report)

Papavasiliou, C.; Kouvaris, John; Athanasiadis, P.; Patrinou, Alexandra; Deligeorgi, H

doi:10.1016/s0167-8140(87)80183-4

Cited by 4 publications

(2 citation statements)

References 10 publications

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“…A MEDLINE search of the English literature from 1966 to 1999 for NPC and SMT identified 31 patients, for a total of 35 patients. [6][7][8][9][10][11][12][13][14][15][16][17]…”

Section: Methodsmentioning

confidence: 99%

Second Malignant Tumors After Treatment of Nasopharyngeal Carcinoma: Four Case Reports and Literature Review

Malone¹,

Levin²

2004

Skull Base

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The purpose of this study was to identify the histopathology, location, and latency interval for the development of second malignant tumors (SMT) after successful treatment for nasopharyngeal carcinoma (NPC). Of 55 patients, four developed SMT after successful treatment of NPC in a single institutional series for an incidence of 7%. An additional 31 patients with SMT after treatment for NPC were identified from the literature. At minimum, all patients were treated with radiotherapy to the primary site. The histopathology of SMT included sarcoma (69%), squamous cell carcinoma (17%), adenocarcinoma (6%), meningioma (6%), and lymphoma (3%). SMT occurred at various sites in the head and neck, but most (51%) arose in the sinonasal cavity. For the entire group, the mean latency interval between treatment for NPC and the development of SMT was 11.8 years. These findings indicate that the development of SMT in patients achieving long-term survival after treatment for NPC may be radiation induced. Long-term follow-up for these patients is important to assess for this potentially late complication.

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“…A MEDLINE search of the English literature from 1966 to 1999 for NPC and SMT identified 31 patients, for a total of 35 patients. [6][7][8][9][10][11][12][13][14][15][16][17]…”

Section: Methodsmentioning

confidence: 99%

Second Malignant Tumors After Treatment of Nasopharyngeal Carcinoma: Four Case Reports and Literature Review

Malone¹,

Levin²

2004

Skull Base

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“…Sekonder amenore de görülebilecek hormonal bozukluklardandır. Radyasyon sahası içerisinde mandibuler osteosarkom ve bazal hücreli karsinoma ikincil kanser olarak rastlanılabilir 13 .…”

Section: Radyoterapiunclassified

Akdeniz Havzasında Sık Görülen Çocukluk Çağı Tümörü: Nazofarinks Karsinomu

Küpeli¹

2015

Arşiv Kaynak Tarama Dergisi

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Nasopharyngeal carcinoma is a rare malignancy of childhood having different epidemiological, histopathological and clinical characteristics. The most frequent histopathological type is undifferentiated nasopharyngeal carcinoma and is associated with advanced locoregional disease and distant metastasis in childhood. Because of high incidence of systemic disease in childhood, chemotherapy is the first choice in treatment of advanced disease. Although 5 year's survival rates have reached 70% with combined therapy modalities, late complications continue to be major problem. Parallel to improvement in the diagnostic skills and therapy, there is an increase in survivors of childhood cancer. Since late effects of cancer therapy can be encountered more often, closer followup of nasopharyngeal carcinoma patients who are under serious treatment schemes is an obligation. Key words: Childhood nasopharyngeal carcinoma, therapy modalities, complications. ÖZETNazofarinks karsinomu çocuklarda nadir görülen, farklı epidemiyolojik, histopatolojik ve klinik özellikleri olan bir hastalıktır. Çocuklarda görülen histopatolojik tip hemen her zaman indiferansiye nazofarinks karsinomu olmakta ve ileri lokal-bölgesel yayılımla ve uzak metastazla birliktelik görülmektedir. Çocuklarda görülen sistemik hastalık sıklığının yüksek oluş nedeniyle günümüzde kemoterapi ileri evre hastalıkta ilk seçenek olarak tercih edilmektedir. Kombine tedavi şemalarıyla 5 yıllık sağkalım % 70'Iere ulaşmış olmasına rağmen geç dönem komplikasyonlar önemli sorun olmaya devam etmektedir. Tanı ve tedavideki gelişmelere paralel olarak, çocukluk çağında kanser tedavisi

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Radiation Induced Sarcomas of the Head and Neck Following Radiotherapy for Nasopharyngeal Carcinoma

King¹,

Ahuja²,

Teo³

et al. 2000

Clinical Radiology

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Mandibular sarcoma as a second neoplasm following radiotherapy for a nasopharyngeal carcinoma in childhood (Case report)

Cited by 4 publications

References 10 publications

Second Malignant Tumors After Treatment of Nasopharyngeal Carcinoma: Four Case Reports and Literature Review

Second Malignant Tumors After Treatment of Nasopharyngeal Carcinoma: Four Case Reports and Literature Review

Akdeniz Havzasında Sık Görülen Çocukluk Çağı Tümörü: Nazofarinks Karsinomu

Radiation Induced Sarcomas of the Head and Neck Following Radiotherapy for Nasopharyngeal Carcinoma

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