Radiation Induced Sarcomas of the Head and Neck Following Radiotherapy for Nasopharyngeal Carcinoma

King, Ann D.; Ahuja, Anil T.; Teo, Peter M.L.; Tse, Gary M.; Kew, J.

doi:10.1053/crad.2000.0503

Cited by 50 publications

(33 citation statements)

References 11 publications

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“…The 3-year OS rate for patients with RIS in our series (32.4%) was within the lower end of the wide range reported previously (8%-60% at 5 years). [3][4][5][6][7][8][9][10][11][12][13]34 The best survival outcome was reported by Tabone et al, 35 who reported that the OS and eventfree survival rates for 23 patients with radiation-related osteosarcoma at 8 years were 50% and 41%, respectively.…”

Section: Radiation-induced Sarcoma In Npc/xi Et Almentioning

confidence: 99%

Radiation‐induced sarcoma in patients with nasopharyngeal carcinoma

Liu

Wang

et al. 2010

Cancer

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BACKGROUND:The increasing incidence of radiation-induced sarcoma (RIS) has become a significant problem that can limit long-term survival. The objective of the current study was to analyze the clinicopathologic characteristics, treatment outcomes, and prognostic factors of RIS after radiotherapy for nasopharyngeal carcinoma (NPC). METH-ODS: Institutional electronic medical records of patients with NPC who received definitive radiotherapy between February 1964 and 2003 were reviewed. Fifty-three patients who developed RIS and fulfilled the study criteria were included. RESULTS: The median follow-up after a diagnosis of RIS was 15.5 months (range, 0.4-90.3 months), and the median latency between radiotherapy for NPC and an RIS diagnosis was 9.3 years (range, 3.2-26.6 years). Fibrosarcoma was the most frequent histologic type observed, followed by osteosarcoma, and malignant fibrous histiocytoma. The 3-year overall survival (OS) rate for 49 patients who received treatment was 32.4%, and the median survival was 21.2 months (95% confidence interval, 8.7-33.8 months). The median OS was 41.3 months, 8.4 months, and 11 months for the complete resection group, the incomplete resection group, and the chemotherapy group, respectively (P<.0001). The only independent predictive factor that was associated with better OS was complete surgical resection. CONCLUSIONS: This retrospective study confirmed the rarity and poor prognosis of RIS in patients with NPC. Complete surgical resection was a significant prognostic factor for survival. The authors concluded that long-term follow-up is necessary for the early detection of RIS in patients with NPC. Cancer 2010;116:5479-86.

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Section: Radiation-induced Sarcoma In Npc/xi Et Almentioning

confidence: 99%

Radiation‐induced sarcoma in patients with nasopharyngeal carcinoma

Liu

Wang

et al. 2010

Cancer

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“…The fact that they occur within the radiation field, as in our case, supports the theory that they arise de novo. 2 Other supporting evidence lies in the fact that, in children less than 10 years of age, the length of the latency period between radiation and cavernous haemangioma formation has been shown to be dependent on the total radiation dose. 13 In children, the higher the radiation dose, over 30 Gy, the shorter the latency period; in adults, cavernous haemangiomas have been shown to develop only above a 30 Gy threshold.…”

Section: Discussionmentioning

confidence: 99%

“…This is above the 55 Gy at which the dose-response relationship between radiation dose and secondary induced tumour risk has been demonstrated to increase. 2 The common complications of radiotherapy to the head and neck have been well documented. Some rarer complications which have been reported after NPC radiotherapy, with potentially serious consequences, include temporal bone necrosis and abscess formation, 3 temporal bone tumours, 4 sarcomas, 2 and, in the current case, cavernous haemangioma.…”

Section: Discussionmentioning

confidence: 99%

“…2 The common complications of radiotherapy to the head and neck have been well documented. Some rarer complications which have been reported after NPC radiotherapy, with potentially serious consequences, include temporal bone necrosis and abscess formation, 3 temporal bone tumours, 4 sarcomas, 2 and, in the current case, cavernous haemangioma. The five-year incidence of secondary primary tumours following radiotherapy for NPC has been shown to be 5.8 per cent.…”

Section: Discussionmentioning

confidence: 99%

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Development of cavernous haemangioma following radical chemo-radiotherapy for nasopharyngeal carcinoma

2009

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Objective: We report an adult case of nasopharyngeal carcinoma treated with radical chemo-radiotherapy, with subsequent development of a histologically proved temporal cavernous haemangioma within the radiation field.Method: Case report and review of the current literature concerning radiation-induced, secondary, space-occupying lesions.Conclusion: The increasing role of radiotherapy in nasopharyngeal carcinoma treatment, together with improved patient survival, is likely to lead to radiation-induced, secondary, space-occupying lesions being encountered more frequently. We emphasise the need to be vigilant for this important but relatively rare complication, which has significant associated morbidity.

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“…The crude incidence of radiation-induced squamous cell cancer in the oral cavity was 1.4% [4]. The incidence of RITs ranges from 0.037%-7% in different series in the literature [3][4][5][6][7]. Although rare, these tumors are often very aggressive, strongly suggesting the need for early detection in order to allow timely intervention.…”

Section: Introductionmentioning

confidence: 99%

Radiation-Induced Maxillary Osteosarcoma and Synchronous Oropharyngeal Squamous Cell Cancer: A Rare Case Report

Paşaoğlu¹

2017

Int J Radiol Imaging Technol

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Radiotherapy is a treatment option for nasopharyngeal cancer. However, ionizing radiation may lead to development of secondary malignancies. In this case report, we will present a case of radiation-induced osteosarcoma of the maxilla and synchronous oropharyngeal squamous cell cancer following treatment of nasopharyngeal cancer. History, latency period, physical examinations, computed tomography, magnetic resonance imaging and biopsy results are provided. Diagnosis was confirmed by excision biopsy. Radiation-induced tumors are possible long-term side effects of radiotherapy. Although rare and possible to confuse with recurrent disease, this possibility should be considered in any patient who has received radiation therapy. Diagnostic imaging plays a pivotal role in recognition of radiation induced neoplastic disease. Accurate identification and reporting of key imaging findings allows referring physicians to choose the most appropriate treatment options.

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Radiation Induced Sarcomas of the Head and Neck Following Radiotherapy for Nasopharyngeal Carcinoma

Cited by 50 publications

References 11 publications

Radiation‐induced sarcoma in patients with nasopharyngeal carcinoma

Radiation‐induced sarcoma in patients with nasopharyngeal carcinoma

Development of cavernous haemangioma following radical chemo-radiotherapy for nasopharyngeal carcinoma

Radiation-Induced Maxillary Osteosarcoma and Synchronous Oropharyngeal Squamous Cell Cancer: A Rare Case Report

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