Mandibular metastasis of adenocarcinoma from prostate cancer: case report according to epidemiology and current therapeutical trends of the advanced prostate cancer

Abstract

Prostate cancer represents the most frequent non-cutaneous neoplasia in males. This type of neoplasia can develop peculiar patterns of evolution, presenting, in many cases, precocious relapses and metastasis. Bone metastasis in the mouth is extremely rare, and represents 1% of all malignant mouth neoplasias. The aim of the present study is to report a clinical case of bone metastasis in the mandibular region associated with a tumoral prostate adenocarcinoma, as well as to discuss connected aspects about diagnosis, prognosis and integrated treatment of this condition.

Prostate adenocarcinoma mandibular metastasis associated with numb chin syndrome: a case report

“…The Gleason score is the sum of the pattern-number of the primary and secondary grades based upon microscopic appearances. A score of 2 to 4 (well differentiated) is mild, while a score of 7 to 10 is more aggressive and has a bad prognosis5. In this case, the primary tumor grade was 4 and the secondary tumor grade was 4, so the Gleason score was 4+4=8.…”

Metastasis of a prostate adenocarcinoma to mandible: A case report and review of literature

“…However, most patients with oral metastasis generally have the primary cancer well diagnosed. In a case reported by Menezes et al, radical prostatectomy was done for the patient 3 years before mandible metastasis and because patient's chief complaint which was pain and paresthesia, he was on neurologic drugs with a diagnosis of trigeminal neuralgia 2 . Metastatic tumors of the head and neck are most commonly located in the mandibular molar region 3 .…”

“…Bone metastasis in oral cavity is extremely rare and represents 1% of all malignant oral neoplasia. The incidence of prostate cancer metastasis in the maxillofacial region is 80 to 90% in mandible, mainly in molar region, and is always a sign of spreading of the cancer 2 …”

Presentación inusual de cavidad ósea de Stafne: estudio mediante tomografía computarizada y resonancia magnética

“…En el paciente del caso descrito, la imagen mostraba un aspecto radiolúcido de bordes irregulares que compromete la pared lateral del conducto mandibular, lo cual es atípico en una CS, aunque Minowa et al 15 consideren dentro de su clasificación un tipo de defecto con "margen irregular". La apariencia osteolítica, la localización basal de la cavidad y el antecedente de CA de próstata del paciente hizo sospechar la presencia de una metástasis, debido también a que este tipo de lesiones puede observarse como una radiolucencia difusa, de bordes mal definidos y aspecto osteolítico 24,25 , semejante a lo observado en el caso. La TCHC de FOV reducido, indicada inicialmente para la valoración del diente 36, permitió conocer la extensión de la cavidad, el aspecto de sus bordes y la relación de la misma con las estructuras vecinas adyacentes, en coincidencia con lo relatado en otros estudios 4,9,13 , sin embargo, debido a las limitaciones propias de este recurso de imagen, en cuanto a la falta de contraste para el tejido blando, no pudo conocerse la naturaleza del contenido.…”