Mandibular cuniculatum carcinoma: Apropos of 3 cases and literature review

Pons, Y.; Kerrary, Siham; Cox, Amanda J.; Guerre, Agnès; Bertolus, Chloé; Gruffaz, Françoise; Capron, Frédérique; Goudot, P.; Ruhin-Poncet, Blandine

doi:10.1002/hed.21493

Cited by 43 publications

(55 citation statements)

References 4 publications

(19 reference statements)

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“…Similarly, other studies have also reported the use of multiple antibiotics to treat a misdiagnosed abscess or osteomyelitis [12,14,16,24]. In regards to esophageal carcinoma cuniculatum, a number of authors have also reported carcinoma cuniculatum mimicking benign esophageal lesions such as Crohn's, esophagitis, and esophageal strictures [13].…”

Section: Discussionmentioning

confidence: 93%

Extensive carcinoma cuniculatum of the mandible

Shay

Choy²,

Christensen

et al. 2015

American Journal of Otolaryngology

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Section: Discussionmentioning

confidence: 93%

Extensive carcinoma cuniculatum of the mandible

Shay

Choy²,

Christensen

et al. 2015

American Journal of Otolaryngology

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“…Additionally, an increasing number of reports describe CC involving head and neck sites, predominantly the oral cavity [2,4,[9][10][11][13][14][15][16][17][18][19][20][21][22]. Table 1 summarizes all reports of CC occurring in the head and neck which could be identified.…”

Section: Discussionmentioning

confidence: 99%

“…Cystic dilation of these channels is not uncommon. Like verrucous carcinoma (VC), CC tends to be well differentiated with low grade cytonuclear features, making diagnosis difficult to establish on small biopsy samples, often leading to delays in treatment [2]. Although similarities exist between CC and VC, and the literature occasionally uses the terms interchangeably, there are some differences, and the 2005 edition of the WHO Pathology and Genetics of Head and Neck Tumours includes CC as a separate variant of squamous cell carcinoma [3].…”

Section: Introductionmentioning

confidence: 99%

A Rare Case of Carcinoma Cuniculatum Involving the Larynx in Association with a Saccular Cyst

Griffith

Goodstein

Tuluc

et al. 2015

Head and Neck Pathol

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Carcinoma cuniculatum (CC), a rare, well-differentiated variant of squamous cell carcinoma, is uncommon in head and neck sites but when it does occur is most common in the oral cavity. Here we report a rare case of CC involving the larynx. A 49-year-old man presented with 10 months of worsening hoarseness and, despite multiple biopsies, no diagnosis of malignancy could be established. Eventual partial excision of the lesion and histologic review of prior specimens confirmed the diagnosis of CC. Focally, a transition to respiratory epithelium indicated the presence of an associated saccular cyst. Total laryngectomy was performed and 6 months later the patient is free of disease. Only two prior cases of CC have been reported in the larynx. Diagnosis of CC is challenging given the low grade histologic features and awareness of this entity for both treating physicians and the pathologist is important to reach a diagnosis of malignancy. This case highlights the challenges in diagnosis of CC, especially in unusual locations and when associated with other lesions such as a saccular cyst. Awareness of this rare tumor type combined with close communication between treating clinicians, radiologists and pathologists should allow earlier diagnosis and treatment.

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“…Verrucous carcinoma is now known to arise in a variety of epithelial sites, most often the oral mucosa, the larynx, the skin of the genitalia, and the skin of the plantar aspect of the foot [4][5][6][7]. Cervical and distant metastases have not been reported in cases of classic verrucous carcinoma [8,9].…”

Section: Introductionmentioning

confidence: 99%