Verrucous carcinoma (carcinoma cuniculatum) of the head and neck: what do we know now that we did not know a decade ago?

Devaney, Kenneth O.; Ferlito, Alfio; Rinaldo, Alessandra; El‐Naggar, Adel K.; Barnes, Leon

doi:10.1007/s00405-011-1495-0

Cited by 25 publications

(25 citation statements)

References 30 publications

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“…Differential diagnoses of CC have included VC, papillary squamous cell carcinoma (PSCC), and well‐differentiated SCC. Some authors have described CC as the same lesion as VC (23, 24). Burkhardt et al.…”

Section: Discussionmentioning

confidence: 99%

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Clinicopathological evaluation of carcinoma cuniculatum: a variant of oral squamous cell carcinoma

Sun

Kuyama

Burkhardt

et al. 2011

J Oral Pathology Medicine

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Carcinoma cuniculatum (CC) is a rare neoplasm of oral squamous cell carcinoma (OSCC) and remains a histopathological challenge to pathologists because of its low incidence and unique architecture. Therefore, the purpose of this study was to illustrate the clinicopathological findings and biological behavior about this distinctive lesion. Clinical and follow-up information were retrieved from medical charts, and histopathological analyses were performed. Our series included 15 cases of CC, and the study included seven men and eight women, age 44-92. The tongue and mandible were the most frequently affected sites. There were three lymph node metastasis cases, and three local recurrences; one of the patients died of lung metastasis from oral CC. Histopathologically, the point of differential diagnosis with other subtypes of OSCC included unique, cuniculatum architecture and branching crypts. Because of its well-differentiated status, the prognosis of CC is usually optimistic. However, recurrent cases in our study might have possessed invasive biological characters that were not well controlled by conventional treatment; in one case, a portion of the CC transformed into conventional squamous cell carcinoma (SCC). This might suggest that transformed CC rather than primary CC should be further emphasized.

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Section: Discussionmentioning

confidence: 99%

“…Differential diagnoses of CC have included VC, papillary squamous cell carcinoma (PSCC), and well-differentiated SCC. Some authors have described CC as the same lesion as VC (23,24). Burkhardt et al (25) described conspicuous, deep duct-like formations and keratin-filled sinuses were peculiar to CC.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological evaluation of carcinoma cuniculatum: a variant of oral squamous cell carcinoma

Sun

Kuyama

Burkhardt

et al. 2011

J Oral Pathology Medicine

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“…Clinically, OVC appear as exophytic masses with a verrucous surface but, less often, they may be relatively smooth. Furthermore, OSCC can have a superficial verrucous appearance, thus morphological features alone can lead to misclassification with consequences for patient management that may include unnecessary neck dissections . For this reason, new approaches are needed.…”

Section: Discussionmentioning

confidence: 99%

A novel genomic signature reclassifies an oral cancer subtype

Samman

Wood

Conway

et al. 2015

Intl Journal of Cancer

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Verrucous carcinoma of the oral cavity (OVC) is considered a subtype of classical oral squamous cell carcinoma (OSCC). Diagnosis is problematic, and additional biomarkers are needed to better stratify patients. To investigate their molecular signature, we performed low-coverage copy number (CN) sequencing on 57 OVC and exome and RNA sequencing on a subset of these and compared the data to the same OSCC parameters. CN results showed that OVC lacked any of the classical OSCC patterns such as gain of 3q and loss of 3p and demonstrated considerably fewer genomic rearrangements compared to the OSCC cohort. OVC and OSCC samples could be clearly differentiated. Exome sequencing showed that OVC samples lacked mutations in genes commonly associated with OSCC (TP53, NOTCH1, NOTCH2, CDKN2A and FAT1). RNA sequencing identified genes that were differentially expressed between the groups. In silico functional analysis showed that the mutated and differentially expressed genes in OVC samples were involved in cell adhesion and keratinocyte proliferation, while those in the OSCC cohort were enriched for cell death and apoptosis pathways. This is the largest and most detailed genomic and transcriptomic analysis yet performed on this tumour type, which, as an example of non-metastatic cancer, may shed light on the nature of metastases. These three independent investigations consistently show substantial differences between the cohorts. Taken together, they lead to the conclusion that OVC is not a subtype of OSCC, but should be classified as a distinct entity.

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“…El inicio de la lesión puede aparecer en cualquier parte del cuerpo y dependiendo del lugar de asentamiento existen tres tipos: el carcinoma verrucoso de aparato digestivo, el de la zona genital y el cutáneo que es el tipo de carcinomas que se pueden encontrar a nivel del pie 4,5 . Este tumor es relativamente raro y generalmente suele aparecer en la etapa adulta, con predominancia en la sexta década de la vida y en varones blancos con un porcentaje de casos del 85 % 6,7,8 . El carcinoma verrucoso es probablemente causado por el VPH y se asocia más con los tipos del VPH 6 y VPH 11 y se cree que representa una lesión intermedia en un continuo desde lo menos patológico la verruga a los más invasivo el carcinoma de células escamosas 9,10 .…”

Section: Introductionunclassified

Carcinoma verrucoso plantar. A propósito de un caso poco frecuente

López‐López

Sanz

Ponce

et al. 2013

Rev. Int. Cienc. Podol.

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Los autores declaran no tener ningún tipo de interés económico o comercial. RESUMEN Antecedentes:Los carcinomas verrucosos en pocas ocasiones se mencionan en la literatura su localización en la planta de los pies, siendo una variante bien diferenciada del carcinoma de células escamosas visto en mucosa y piel, incluyendo los pies. Objetivo: Describir las características clínicas, histopatológicas y de laboratorio y los resultados de un caso clínico inusual de un carcinoma verrucoso en la planta del pie. Métodos: Presentamos un extraño caso de un carcinoma verrucoso en la planta del pie izquierdo, a nivel del primer metatarsiano, que fue resecado completamente y se quedó sin evidencia de recidiva tumoral o metástasis, durante el seguimiento en un periodo de 4 años. Sobre esta base, se revisaron los casos publicados de carcinoma verrucoso en el pie, para definir las peculiaridades de este tumor poco común y para dar recomendaciones diagnósticas y terapéuticas. Resultados: El carcinoma verrucoso se caracteriza por una presentación clínica lenta pero inexorablemente amplia de aspecto similar a la verruga plantar, la histología típica es una invasión local mínima con baja incidencia de metástasis y buen pronóstico. Para el diagnóstico correcto, tanto el examen físico y el complementario debe ser exhaustivo y realizado mediante biopsia quirúrgica. La resección radical es el tratamiento de elección con confirmación histológica de los márgenes de resección libres del tumor. Conclusiones: El carcinoma verrucoso plantar puede presentar dificultad diagnóstica, la resección quirúrgica completa de la lesión permite el diagnóstico, presenta un buen pronóstico y pronta curación. Palabras clave: carcinoma verrucoso; epitelioma cuniculatum; carcinoma de células escamosas; tumor.http://dx

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Verrucous carcinoma (carcinoma cuniculatum) of the head and neck: what do we know now that we did not know a decade ago?

Cited by 25 publications

References 30 publications

Clinicopathological evaluation of carcinoma cuniculatum: a variant of oral squamous cell carcinoma

Clinicopathological evaluation of carcinoma cuniculatum: a variant of oral squamous cell carcinoma

A novel genomic signature reclassifies an oral cancer subtype

Carcinoma verrucoso plantar. A propósito de un caso poco frecuente

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