Managing the consequences of aggressive conservative treatment for refractory retinoblastoma with vitreous seeding

Brink, Aubrey; Corrêa, Zélia M.; Geller, James I.; Abruzzo, Todd; Augsburger, James J.

doi:10.5935/0004-2749.20140064

Cited by 3 publications

(1 citation statement)

References 12 publications

(24 reference statements)

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“…Systemic and local (ophthalmic artery/intravitreal) chemotherapy is the major therapeutic strategies of RB. 1 , 2 However, there are limitations for the chemotherapy of RB, such as drug resistance and side effects. 3 Therefore, further identification of biomarkers of RB progression will be helpful for developing new molecular prognostic indicators and novel treatment strategies.…”

Section: Introductionmentioning

confidence: 99%

LRPPRC regulates metastasis and glycolysis by modulating autophagy and the ROS/HIF1-α pathway in retinoblastoma

Song

Chen

et al. 2021

Molecular Therapy - Oncolytics

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Retinoblastoma (RB) is the most common intraocular tumor among children. Leucine-rich pentatricopeptide repeat (PPR)-motif-containing protein (LRPPRC), a suppressor gene of autophagy, has been proven to play a regulatory role in tumor progression. However, little is known about functional roles and mechanisms of LRPPRC in RB progression. First, we performed a detailed analysis for RB and normal control. The expression of LRPPRC in the RB tissues was significantly higher than that in normal tissues. Moreover, LRPPRC suppression could repress tumor cell migration, invasion, glycolysis, and reactive oxygen species (ROS)/hypoxia-inducible factor-1α (HIF1-α) pathway activation by mediating autophagy. Furthermore, overexpression of HIF1-α partially reversed the above changes induced by LRPPRC knockdown. The regulation of LRPPRC on tumor metastasis and glycolysis was also validated by a xenograft tumor assay. In summary, LRPPRC could regulate metastasis and glycolysis of RB by mediating autophagy suppression and further activating the ROS/HIF1-α pathway, and LRPPRC could be a promising prognostic biomarker for RB.

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Section: Introductionmentioning

confidence: 99%