Management of thyroid dysfunctions in the elderly. French Endocrine Society consensus statement 2019. Long version

Goichot, B.; Raverot, Véronique; Klein, M.; Racaru, Lavinia Vija; Payrat, Juliette Abeillon-du; Lairez, Olivier; Leroy, R.; Cailleux, Anne-Françoise; Wolff, Pierre; Groussin, Lionel; Kaltenbach, Georges; Caron, Philippe

doi:10.1016/j.ando.2020.04.010

Cited by 11 publications

(19 citation statements)

References 128 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The trend of FT4 concentrations in older population was consistent with previous studies which also demonstrated little change of FT4 concentrations with aging [26]. This stability despite aging may be due to a combination of reduced T4 synthesis and secretion by the thyroid cells and reduced metabolic thyroxine clearance [5]. Increasing in TSH with aging was observed based on this population.…”

Section: Discussionsupporting

confidence: 90%

“…We investigated a rapid decrease in FT3 with aging in the older population. This may be due to reduced activity of 5'mono-deiodase, which catalyzes deiodination of T4 into T3, or/and reduced stimulation by TSH with aging [5]. The trend of FT4 concentrations in older population was consistent with previous studies which also demonstrated little change of FT4 concentrations with aging [26].…”

Section: Discussionsupporting

confidence: 87%

“…Several studies have demonstrated the association between the presence of low T3 condition and acceleration of progression of disease and some adverse outcomes in patients with heart disease or surgery therapy in older adults [13,22,25]. Studies and guidelines to date concentrate on the cardio and mental prognosis in patients with low T3 and rare of those pay attention to the kidney prognosis [5,21]. Thus, our study revealed that low FT3 level even in the reference interval may be a risk factor for the incidence of mildly reduced or reduced kidney function in the older population.…”

Section: Discussionmentioning

confidence: 99%

“…Thyroid function has been suggested as an in uencing factor affecting kidney function through regulation of renal blood ow, renin-angiotensin-aldosterone system, tubular mass and glomerular architecture in the general population [7][8][9]. Indexes of thyroid function vary with aging, thus the association of thyroid function and declining kidney function in older adults was different from this in the young and remains controversial [5]. Previous studies demonstrated that thyroid dysfunction was associated with estimated GFR (eGFR) and likelihood of prevalent CKD [6,17].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Thyroid Function and Reduced Kidney Function with Aging in Chinese Older Adults: A Cross- sectional Study

Lü

Bai

Yong

et al. 2021

Preprint

View full text Add to dashboard Cite

Background: Thyroid function may be a factor influencing renal function in general population. Renal function and thyroid function vary with aging, thus the association of thyroid function and declining kidney function in older adults was different from this in the young and remains controversial. The aim of this study was to estimate association between thyroid function in reference interval and reduced kidney function with aging in Chinese older adults.Methods: A total of 15729 adults, 23.3% (N= 3624) of which were older population, were collected in the health check-up department of the First Affiliated Hospital of Nanjing Medical University between January 2018 to January 2020.Basic demographic information was collected by physician-administered questionnaire. The variation tendency of thyroid function with aging was investigated by mean of free triiodothyronine (FT3), free thyroxine (FT4) and thyroid stimulatinghormone (TSH) in subgroups for every 10 years. Associations between kidney and thyroid function were estimated with β value by multiple linear regression and with odds ratio (OR) by multivariable logistic regression models adjusted for age, gender, body mass index and serum urine acid. Results: In the older population, an increased trend of TSH, a decreased trend of FT3 and little change of FT4 were identified with aging. Estimated glomerular filtration rate (eGFR) remarkably decreased with increasing TSH (β: -0.081) and declining FT3 (β: 0.083) concentrations. Compared with the population in the lowest FT3 quartile (3.10-4.45 pmol/L), the prevalence of eGFR< 75ml/min/1.73m2 significantly decreased by 22.0% with FT3 4.46-4.81 pmol/L, 27.6% with FT3 4.82-5.20 pmol/L and 34.9% with FT3 5.21-6.8 pmol/L in older individuals (P for trend <.001). The OR was 1.315 with high-normal TSH, comparing to low-normal TSH in older persons (P: 0.025). Similar results were found between prevalent eGFR< 60ml/min/1.73m2 and thyroid function. The prevalent reduced kidney function was not remarkably associated with FT4 in the reference range.Conclusions: This study demonstrated a significant association between thyroid function and kidney function, especially FT3 in older population. The clinician were advised to evaluate renal function with low-normal FT3 and high-normal TSH in case of potential decreased kidney function.

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Thyroid Function and Reduced Kidney Function with Aging in Chinese Older Adults: A Cross- sectional Study

Lü

Bai

Yong

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…The bulk data suggest that overall QoL is good in LT4-treated patients with hypothyroidism-even when symptoms are present (or persist)-but do not explain why a few percent of biochemically corrected patients complain of poor QoL. A few studies (such as those by Mooijaart et al [ 88 ] and Recker et al [ 89 ]) focused on older patients with SCH, in whom the definition of hypothyroidism differs [ 106 ]; we suggest that the assessment of other well-defined patient populations might facilitate the identification of risk factors for poor QoL.…”

Section: Discussionmentioning

confidence: 99%

What Is the Quality of Life in Patients Treated with Levothyroxine for Hypothyroidism and How Are We Measuring It? A Critical, Narrative Review

Borson‐Chazot

Terra

Goichot

et al. 2021

JCM

Self Cite

View full text Add to dashboard Cite

Thyroid hormone replacement therapy (THRT, generally using oral levothyroxine (LT4)) is a safe, effective means of treating hypothyroidism. However, a proportion of LT4-treated patients with biochemically normal thyroid function tests complain of persistent symptoms that impact their health-related quality of life (QoL). The objectives of this critical, narrative review of the literature were to identify studies of QoL in LT4-treated patients with hypothyroidism, examine the instruments used to measure QoL, determine whether normal QoL is restored by THRT, and identify factors associated with QoL. The PubMed database was searched from 1 January 2000 to 31 December 2020. A total of 809 publications were screened, 129 full-text articles were retrieved, and 58 were analyzed. The studies of overt hypothyroidism evidenced an improvement in psychological and emotional well-being after three to six months of THRT with LT4, although contrasting results were found for patients with subclinical hypothyroidism. Combination treatment with LT4 and liothyronine was not generally associated with better QoL. In hypothyroidism, QoL appears to be influenced by a number of physiological, behavioral, cognitive and/or lifestyle factors that are not strictly related to thyroid hormone levels.

show abstract

Évaluation biologique de la fonction thyroïdienne

Raverot¹,

d’Herbomez²

2022

Les Maladies De La Thyroïde

View full text Add to dashboard Cite

Management of thyroid dysfunctions in the elderly. French Endocrine Society consensus statement 2019. Long version

Cited by 11 publications

References 128 publications

Thyroid Function and Reduced Kidney Function with Aging in Chinese Older Adults: A Cross- sectional Study

Thyroid Function and Reduced Kidney Function with Aging in Chinese Older Adults: A Cross- sectional Study

What Is the Quality of Life in Patients Treated with Levothyroxine for Hypothyroidism and How Are We Measuring It? A Critical, Narrative Review

Évaluation biologique de la fonction thyroïdienne

Contact Info

Product

Resources

About